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J-GLOBAL ID：202102267461723652   Reference number：21A0160285

Generation of gene-corrected iPSCs line (KEIUi001-A) from a PARK8 patient iPSCs with familial Parkinson’s disease carrying the I2020T mutation in LRRK2

LRRK2におけるI2020T変異を有する家族性Parkinson病を有するPARK8患者iPSCからの遺伝子補正iPSCs系統(KEIUi001-A)の生成【JST・京大機械翻訳】

Author (14)： Ohta Etsuro (R & D Center for Cell Design, Institute for Regenerative Medicine and Cell Design, Kitasato University School of Allied Health Sciences, Japan) ,  Ohta Etsuro (Department of Immunology II, Kitasato University School of Allied Health Sciences, Japan) ,  Ohta Etsuro (Division of Clinical Immunology, Graduate School of Medical Sciences, Kitasato University, Japan) ,  Ohta Etsuro (Department of Physiology, Keio University School of Medicine, Japan) ,  Sone Takefumi (Department of Physiology, Keio University School of Medicine, Japan) ,  Ukai Hideki (International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Japan) ,  Hisamatsu Tomoko (Medical Laboratory Department, Kitasato University Hospital, Japan) ,  Kitagawa Tokiko (Medical Laboratory Department, Kitasato University Hospital, Japan) ,  Ishikawa Mitsuru (Department of Physiology, Keio University School of Medicine, Japan) ,  Nagai Makiko (Department of Neurology, Kitasato University School of Medicine, Japan) ,  Ueda Hiroki R. (Laboratory for Synthetic Biology, RIKEN Center for Biosystems Dynamics Research, Japan) ,  Ueda Hiroki R. (Department of Systems Pharmacology, Graduate School of Medicine, The University of Tokyo, Japan) ,  Obata Fumiya (Kitasato Junior Colledge of Health and Hygienic Sciences, Japan) ,  Okano Hideyuki (Department of Physiology, Keio University School of Medicine, Japan)
Material： Stem Cell Research (Web)  (Stem Cell Res (Web))
Volume： 49  Page： Null  Publication year： 2020 
JST Material Number： U7041A  ISSN： 1873-5061  Document type： Article
Article type： 短報  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Leucine-rich repeat kinase 2 (...

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Thesaurus term： *gene ,  Phenotype ,  versatility ,  Karyotype ,  *Parkinson's disease ,  pathological state ,  pluripotent stem cell ,  autosomal dominant inheritance ,  causative gene ,  *leucine rich repeat kinase 2 ,  cell type ,  kinase ,  TALEN ,  Gene Editing
Semi thesaurus term： 家族性パーキンソン病 ,  ゲノムエディティング , 【Automatic Indexing@JST】

JST classification (2)： Development(=generation)and differentiation  (EJ16020W) ,  Cell physiology in general  (EF02010S)

Terms in the title (7)： LRRK2 ,  変異 ,  家族性Parkinson病 ,  患者 ,  IPSC ,  遺伝子 ,  系統