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J-GLOBAL ID：202102271433507755   Reference number：21A0348809

Secreted PD-L1 variants mediate resistance to PD-L1 blockade therapy in non-small cell lung cancer

分泌PD-L1変異体は非小細胞肺癌におけるPD-L1遮断療法に対する耐性を仲介する【JST・京大機械翻訳】

Author (20)： Gong Bo (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Gong Bo (Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan) ,  Kiyotani Kazuma (Immunopharmacogenomics Group, Cancer Precision Medicine Center, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Sakata Seiji (Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Nagano Seiji (Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan) ,  Nagano Seiji (Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Kumehara Shun (Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan) ,  Kumehara Shun (Department of Hematology and Oncology, Graduate School of Medicine, Kyoto University, Kyoto, Japan) ,  Baba Satoko (Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Besse Benjamin (INSERM U981, Gustave Roussy Cancer Campus, Universite Paris Saclay, Villejuif, France) ,  Besse Benjamin (Department of Cancer Medicine, Gustave Roussy Cancer Campus, Villejuif, France) ,  Yanagitani Noriko (The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Friboulet Luc (INSERM U981, Gustave Roussy Cancer Campus, Universite Paris Saclay, Villejuif, France) ,  Nishio Makoto (The Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Takeuchi Kengo (Pathology Project for Molecular Targets, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Takeuchi Kengo (Division of Pathology, Cancer Institute, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Kawamoto Hiroshi (Laboratory of Immunology, Institute for Frontier Life and Medical Sciences, Kyoto University, Kyoto, Japan) ,  Fujita Naoya (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan) ,  Fujita Naoya (Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan) ,  Katayama Ryohei (Cancer Chemotherapy Center, Japanese Foundation for Cancer Research, Tokyo, Japan)
Material： Journal of Experimental Medicine  (J Exp Med)
Volume： 216  Issue： 4  Page： 982-1000  Publication year： 2019 
JST Material Number： A0937B  ISSN： 0022-1007  Document type： Article
Article type： 原著論文  Country of issue： United States (USA)  Language： ENGLISH (EN)

Abstract/Point： Immune checkpoint blockade aga...

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Thesaurus term： gene ,  antibody ,  tumor ,  tumor cell ,  wild type ,  *non-small cell lung cancer ,  CD8 antigen ,  coculture ,  programmed cell death ,  splice variant ,  *Antigens, CD274 ,  HLA matching
Semi thesaurus term： 耐性機構 ,  治療抵抗性 ,  異種移植片 , 【Automatic Indexing@JST】

JST classification (1)： Immunotherapy for tumors  (GE03035B)

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Terms in the title (8)： 分泌 ,  PD-L1 ,  変異体 ,  非小細胞肺癌 ,  遮断 ,  療法 ,  耐性 ,  仲介