Art

J-GLOBAL ID：202102272918859635   Reference number：21A0721309

Metabolic Functions of G Protein-Coupled Receptors in Hepatocytes-Potential Applications for Diabetes and NAFLD

肝細胞におけるG蛋白質共役受容体の代謝機能-糖尿病とNAFLDに対する潜在的応用【JST・京大機械翻訳】

Author (6)： Kimura Takefumi (Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20894, USA) ,  Kimura Takefumi (Department of Internal Medicine, Division of Gastroenterology, Shinshu University School of Medicine, Matsumoto 390-8621, Japan) ,  Pydi Sai P. (Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20894, USA) ,  Pham Jonathan (Molecular Signaling Section, Laboratory of Bioorganic Chemistry, National Institute of Diabetes and Digestive and Kidney Diseases, National Institutes of Health, Bethesda, MD 20894, USA) ,  Tanaka Naoki (Department of Metabolic Regulation, Shinshu University School of Medicine, Matsumoto 390-8621, Japan) ,  Tanaka Naoki (Research Center for Social Systems, Shinshu University, Matsumoto 390-8621, Japan)
Material： Biomolecules (Web)
Volume： 10  Issue： 10  Page： 1445  Publication year： 2020 
JST Material Number： U7148A  ISSN： 2218-273X  Document type： Article
Article type： 文献レビュー  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： G protein-coupled receptors (G...

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Thesaurus term： *diabetes mellitus ,  metabolic disease ,  membrane receptor ,  type 2 diabetes mellitus ,  *hepatocyte
Semi thesaurus term： *G蛋白質共役型受容体 ,  肝機能 ,  非アルコール性脂肪性肝炎 ,  *非アルコール性脂肪性肝疾患 ,  細胞型 , 【Automatic Indexing@JST】

Author keywords (8)： G protein-coupled receptor ,  GPCR ,  hepatocyte ,  liver ,  metabolism ,  diabetes ,  NAFLD ,  NASH

JST classification (5)： Digestive system diseases  (GH03000W) ,  Metabolic diseases,nutritional diseases in general.  (GD05010J) ,  Basic research of drugs acting on carbohydrate metabolism  (GW13020Q) ,  Drug therapy(=pharmacotherapy)for digestive system diseases  (GH05020G) ,  Receptors on cell membrane  (EF04030C)

Reference (92)：

• Ramskold, D.; Wang, E.T.; Burge, C.B.; Sandberg, R. An abundance of ubiquitously expressed genes revealed by tissue transcriptome sequence data. PLoS Comput. Biol. 2009, 5, e1000598.
• Rui, L. Energy metabolism in the liver. Compr. Physiol. 2014, 4, 177-197.
• Hers, H.G. The control of glycogen metabolism in the liver. Annu. Rev. Biochem. 1976, 45, 167-189.
• Rines, A.K.; Sharabi, K.; Tavares, C.D.; Puigserver, P. Targeting hepatic glucose metabolism in the treatment of type 2 diabetes. Nat. Rev. Drug Discov. 2016, 15, 786-804.
• Postic, C.; Dentin, R.; Girard, J. Role of the liver in the control of carbohydrate and lipid homeostasis. Diabetes Metab. 2004, 30, 398-408.

Terms in the title (6)： 肝細胞 ,  G蛋白質共役受容体 ,  代謝 ,  糖尿病 ,  NAFLD ,  応用