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J-GLOBAL ID：202102282451497462   Reference number：21A0156093

Improved engraftment of human peripheral blood mononuclear cells in NOG MHC double knockout mice generated using CRISPR/Cas9

CRISPR/Cas9を用いて生成されるNOG MHC二重ノックアウトマウスにおけるヒト末梢血単核細胞の移植の改善【JST・京大機械翻訳】

Author (13)： Ka Yuyo (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Katano Ikumi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Nishinaka Eiko (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Welcker Jochen (Taconic Biosciences, Inc., 1 Discovery Drive, Suite 304, Rensselaer, NY, 12144, United States) ,  Mochizuki Misa (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Kawai Kenji (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Goto Motohito (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Tomiyama Kayo (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Ogura Tomoyuki (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Yamamoto Taichi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Ito Mamoru (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Ito Ryoji (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan) ,  Takahashi Riichi (Central Institute for Experimental Animals, 3-25-12 Tonomachi, Kawasaki-ku, Kawasaki, Kanagawa, 210-0821, Japan)
Material： Immunology Letters  (Immunol Lett)
Volume： 229  Page： 55-61  Publication year： 2021 
JST Material Number： E0738B  ISSN： 0165-2478  Document type： Article
Article type： 原著論文  Country of issue： Netherlands (NLD)  Language： ENGLISH (EN)

Abstract/Point： Humanized mice are widely used...

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Thesaurus term： fertility (reproduction) ,  Histocompatibility ,  spleen ,  human ,  Chimera ,  complex (substance) ,  T cell ,  microglobulin ,  GVH disease ,  *peripheral blood ,  *knockout mouse ,  Immune System ,  *PBMCs ,  humanized mice ,  mouse model ,  *laboratory animal ,  *Mus musculus

Author keywords (5)： Humanized mice ,  NOG mice ,  PBMC ,  GVHD ,  MHC

JST classification (1)： Laboratry organisms  (EA03070Y)

Terms in the title (7)： CRISPR ,  Cas9 ,  MHC ,  ノックアウトマウス ,  ヒト ,  末梢血単核細胞 ,  移植