Research field (3)：
Parasitology
, Molecular biology
, Laboratory animal science
Research keywords (4)：
Animal models for human diseases
, Gene-modified animals
, Laboratory Animals
, Humanized mice
Research theme for competitive and other funds (36)：
2018 - 2022 Attempts on standardization of humanized mice by using artificial thymus and hematopoietic stem cells differentiated from human iPS cells.
2017 - 2021 Platform for Supporting Drug Discovery using Humanized Mice
2010 - 2016 Development of experimentation systems related to personalized medicine using humanized NOG mice
2006 - 2010 Basic study to establish “humanized animal model” by improvement and modification of severely immunodeficient NOG mouse
2003 - 2005 Basic studies on animal model for regenerative medicine using severe immunodeficient mice.
2000 - 2004 Hyperphosphorylation and aggregation of tau protein, and neuronal death
1999 - 2003 Generation of cloned mice and their application in the field of laboratory animal science
2001 - 2003 Practical use of cloning technology for NOD and dy disease model mice production
2001 - 2003 Study on their experimetation of gerbils living in China for infectious diseases.
2001 - 2002 Establishment of a leukemia model mouse by introducing mutated FLT3 gene
2001 - 2002 The studies on the practical application of NOD-sc/d, yc null mice allowing an efficient transplantation of human cells, to human disease models
1999 - 2001 Genomic factors of parasites and human beings on malaria severity
1998 - 2000 Development of Chinese Lemming as an Experimental Animal
1998 - 2000 Epidemiology and Control of Leishmaniasis in Central Eurasia ; A new epidemic in association with irrigation of deserts
1998 - 1999 Lymphocyte deficient mice as hosts for xenograft of human cells
1998 - 1999 SEVERE COMBINED IMMUNODEFICIENT (SCID) MICE AS ANIMAL MODELS FOR HUMAN CYSTICERCOSIS AND ECHINOCOCCOSIS (1999)
1996 - 1998 Generation of monoclonal antibodies against lymphocyte surface antigens of new world monkeys and the analysis.
1997 - 1998 Molecular mechanism of selective development in thymocytes analysing DP specific molcules
1996 - 1998 Characterization as experimental animals on mini-pigs in China
1992 - 1993 Polysaccharide of Pneumocystis carinii cyst wall as a new target for therapy
1992 - 1993 疾患モデル系統における疾患形質パラメーターによる形質モニタリングの確立
1991 - 1992 ニューモシスティス・カリニ感染に対する防除方法の研究
1990 - 1992 ESTABLISHMENT AND USE OF ALTERNATIVE DEFINITIVE HOSTS FOR ECHINOCOCCUS
1989 - 1991 Establishment of an Embryo Bank System for Laboratory Animals
1988 - 1989 Expulsion mechanism of adult-taeniid cestodes induced by mucosal responses of definitive hosts.
1986 - 1988 Establishment and application of the laboratory colony of Clethrionomys rufocanus bedfordiae susceptible to Echinococcus multilocularis for the antagonistic competion among taeniid species
Ito R, Katano I, Kwok IWH, Ng LG, Ida-Tanaka M, Ohno Y, Mu Y, Morita H, Nishinaka E, Nishime C, et al. Efficient differentiation of human neutrophils with recapitulation of emergency granulopoiesis in human G-CSF knockin humanized mice. Cell reports. 2022
Hiroshi Tsuzuki, Yasuko Nagatsuka, Mitsuhiro Iwata, Noboru Kitamura, Yosuke Nagasawa, Taro Matsumoto, Ryoji Ito, Takeshi Takahashi, Mamoru Ito, Hideki Nakamura, et al. Antinuclear antibodies produced in HLA-DR transgenic humanized mice developed chronic graft-versus-host disease. Heliyon. 2021. 7. 11. e08380
Ryoji Ito, Ikumi Katano, Iyo Otsuka, Takeshi Takahashi, Hiroshi Suemizu, Mamoru Ito, Peter J Simons. Bovine β-lactoglobulin-induced passive systemic anaphylaxis model using humanized NOG hIL-3/hGM-CSF transgenic mice. International immunology. 2021. 33. 3. 183-189
METHOD FOR EVALUATING HEMATOLOGICAL TOXICITY OF DRUG UNDER EVALUATION, AND MODEL FOR EVALUATING HEMATOLOGICAL TOXICITY OF DRUG UNDER EVALUATION
評価対象薬剤の血液毒性評価方法、及び評価対象薬剤の血液毒性評価用モデル
HUMAN IL-15-SECRETING IMMUNODEFICIENT MOUSE
Method of Constructing Mouse Suitable for the Take, Differentiation and Proliferation of Heterogenous Cells, Mouse Constructed by This Method and Use of the Mouse.
Specific detection of human NK cell mediated in vivo ADCC in FcgR-deficient NOG-human IL-15 transgenic mice.
(The 47th Annual Meeting of The Japanese Society for Immunology 2018)
A new humanized mouse model to investigate large granular lymphocytosis in CML patients and immune modulating effects of dasatinib.
(The 47th Annual Meeting of The Japanese Society for Immunology 2018)
DNAM-1 regulates the Foxp3 stability of regulatory T cells under inflammatory conditions.
(The 47th Annual Meeting of The Japanese Society for Immunology 2018)
Humanized mouse models newly established in CIEA
(Regeneron’s Workshop on Humanized Immune System Mice 2018)
Development of human neutrophils in hG-CSF knock in NOH mouse transferred with human HSC.
(JSH2018 Progress of the Japanese Society of Hematology 2018)
- 1978 Obihiro University of Agriculture and Veterinary Medicine
- 1978 Obihiro University of Agriculture and Veterinary Medicine Graduate School, Division of Animal Sciences
- 1976 Obihiro University of Agriculture and Veterinary Medicine Faculty of Animal Husbandry
- 1976 Obihiro University of Agriculture and Veterinary Medicine Faculty of Animal Science
Professional career (2)：
Doctor of Veterinary Medicine (Hokkaido University)
Master of Veterinary Medicine (Obihiro University of Agriculture and Veterinary Medicine)
Work history (11)：
2023/04 - 現在 Central Institute for Experimental Animals Fellow
2013 - 現在 Central Institute for Experimental Animals Board Member
2020/04 - 2023/03 Central Institute for Experimental Animals Director
2013 - 2020 Central Institute for Experimental Animals Deputy Director
2011 - 2020 Central Institute for Experimental Animals Research Division Chairman
2008 - 2011 Central Institute for Experimental Animals Laboratory Animal Research Department General manager
2005 - 2008 Central Institute for Experimental Animals
1998 - 2008 Central Institute for Experimental Animals Laboratory of gene manipulation chief
1987 - 2008 Central Institute for Experimental Animals Laboratory of Immunology Chief
2000 - 2002 北海道大学・先端科学技術共同研究センター・客員教授
1985 - 1987 Central Institute for Experimental Animals, Laboratory of Immunology Research staff
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Awards (2)：
2015 - International Council for Laboratory Animal Science (ICLAS) Muhlbock-Nomura Award
2015 - Japanese Association of Laboratory Animal Science Ando-Tajima Award
Association Membership(s) (4)：
JAPANESE ASSOCIATION FOR LABORATORY ANIMAL SCIENCE
, THE JAPANESE SOCIETY FOR IMMUNOLOGY
, Japanese Association of Germfree Life and Gnotobiology
, Japan Society of Marmoset Research
