Art

J-GLOBAL ID：202102286590355312   Reference number：21A1432192

BET-Inhibitor I-BET762 and PARP-Inhibitor Talazoparib Synergy in Small Cell Lung Cancer Cells

小細胞肺癌細胞におけるBET阻害剤I-BET762およびPARP阻害剤タラゾパリブ相乗作用【JST・京大機械翻訳】

Author (8)： Fiorentino Francesco Paolo (Department of Biomedical Science, and National Institute of Biostructures and Biosystems, University of Sassari, 07100 Sassari, Italy) ,  Fiorentino Francesco Paolo (Kitos Biotech Srls, Porto Conte Ricerche, 07041 Alghero, Italy) ,  Marchesi Irene (Kitos Biotech Srls, Porto Conte Ricerche, 07041 Alghero, Italy) ,  Schroder Christoph (Sciomics GmbH, 69151 Neckargemuend, Germany) ,  Schmidt Ronny (Sciomics GmbH, 69151 Neckargemuend, Germany) ,  Yokota Jun (Division of Genome Biology, National Cancer Center Research Institute, Chuo-ku, Tokyo 104-0045, Japan) ,  Bagella Luigi (Department of Biomedical Science, and National Institute of Biostructures and Biosystems, University of Sassari, 07100 Sassari, Italy) ,  Bagella Luigi (Center for Biotechnology, Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, College of Science and Technology, Temple University, Philadelphia, PA 19122, USA)
Material： International Journal of Molecular Sciences (Web)  (Int J Mol Sci (Web))
Volume： 21  Issue： 24  Page： 9595  Publication year： 2020 
JST Material Number： U7038A  ISSN： 1422-0067  CODEN： IJMCFK  Document type： Article
Article type： 原著論文  Country of issue： Switzerland (CHE)  Language： ENGLISH (EN)

Abstract/Point： Small cell lung cancer (SCLC) ...

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Thesaurus term： mortality ,  *tumor cell ,  *potentiation ,  lethal action ,  effectiveness ,  targeting ,  *lung tumor ,  down-regulation ,  *small cell lung cancer
Semi thesaurus term： 細胞株 ,  PTEN ,  伝達経路 ,  DNA損傷応答 ,  *PARP阻害剤 , 【Automatic Indexing@JST】

Author keywords (5)： SCLC ,  BET ,  PARP ,  BMN673 ,  GSK-525762A

JST classification (4)： Basic research of antitumor(=antineoplastic)drugs  (GW16010A) ,  Basic research of pharmacology of crude drugs  (GX06020J) ,  Cell physiology in general  (EF02010S) ,  Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N)

Substance index (1)： Talazoprib

Reference (76)：

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Terms in the title (6)： 小細胞肺癌 ,  細胞 ,  BET阻害剤 ,  PARP阻害剤 ,  タラゾパリブ ,  相乗作用