Pat
J-GLOBAL ID:202403021404657372
糖鎖結合性一本鎖抗体およびその作製方法
Inventor:
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Applicant, Patent owner:
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Gazette classification:特許公報
Application number (International application number):2019091686
Publication number (International publication number):2019199472
Patent number:7457895
Application date: May. 14, 2019
Publication date: Nov. 21, 2019
Claim (excerpt):
【請求項1】 糖鎖結合一本鎖抗体の連結部にアミノ酸置換を導入する糖鎖結合一本鎖抗体の改変抗体配列の設計方法であって、 糖鎖結合一本鎖抗体のアミノ酸配列に対して、統計学手法と祖先型設計法に基づいてアミノ酸置換を行い、糖鎖結合性一本鎖抗体の改変抗体のアミノ酸配列を設計する工程、 前記糖鎖結合性一本鎖抗体の改変抗体の配列のうち、可変部位(CDR)を、前記糖鎖結合一本鎖抗体の配列に置換する工程、を備える、糖鎖結合一本鎖抗体の改変抗体配列の設計方法。
IPC (7):
C07K 16/00 ( 200 6.01)
, C40B 60/10 ( 200 6.01)
, C12P 21/08 ( 200 6.01)
, G16B 35/00 ( 201 9.01)
, C12N 1/21 ( 200 6.01)
, C12N 15/13 ( 200 6.01)
, C40B 40/10 ( 200 6.01)
FI (7):
C07K 16/00 ZNA
, C40B 60/10
, C12P 21/08
, G16B 35/00
, C12N 1/21
, C12N 15/13
, C40B 40/10
Patent cited by the Patent:
Article cited by the Patent:
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