Kumasaka Takashi

クマサカタカシ | Kumasaka Takashi

Affiliation and department：
Job title： Director
Other affiliations (1)：

Japan Synchrotron Radiation Research Institute Structural Biology Division Director

Homepage URL (1)： http://stbio.spring8.or.jp/

Research field (4)： Nanobioscience , Quantum beam science , Biophysics , Structural biochemistry

Research keywords (6)：放射光 , X線結晶学 , タンパク質構造 , Synchrotron Radiation , X-ray Crystallography , Protein Structure

Research theme for competitive and other funds (18)：

2019 - 2024 Development of fixed target micro-crystallography dedicated to structural dynamics study
2016 - 2019 Investigation of protein structure and signaling molecule in general stress response in Bacillus subtilis
2014 - 2017 Research on the molecular basis of conformational dynamics of oncogene product Ras for application to the development of its specific inhibitors
2014 - 2016 Structure-function studies of bacterial mitoNEET system
2013 - 2015 枯草菌一般ストレス応答システムの構造と機能の解析

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Papers (180)：

Kenji Fukui, Tatsuya Yamamoto, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Takato Yano. Catalytic mechanism of the zinc-dependent MutL endonuclease reaction. Life Science Alliance. 2023. 6. 10. e202302001-e202302001
Yuya Nishida, Sachiko Yanagisawa, Rikuri Morita, Hideki Shigematsu, Kyoko Shinzawa-Itoh, Hitomi Yuki, Satoshi Ogasawara, Ken Shimuta, Takashi Iwamoto, Chisa Nakabayashi, et al. Identifying antibiotics based on structural differences in the conserved allostery from mitochondrial heme-copper oxidases. Nature Communications. 2022. 13. 1
Maya Nakatani, Shun-ya Nakahara, Kenji Fukui, Momoka Urano, Yuki Fujii, Takeshi Murakawa, Seiki Baba, Takashi Kumasaka, Hiroki Okanishi, Yoshikatsu Kanai, et al. Crystal structure of a nucleotide-binding domain of fatty acid kinase FakA from Thermus thermophilus HB8. Journal of Structural Biology. 2022. 214. 4. 107904-107904
Jacob R. Boos, Hanna N. J, rain, Emi Hagiuda, Alex, er T. Taguchi, Kazuya Hasegawa, Bailey L. Fedun, Sarah J. Taylor, Sofhia M. Elad, et al. Structure and biological evaluation of Caenorhabditis elegans CISD-1/mitoNEET, a KLP-17 tail domain homologue, supports attenuation of paraquat-induced oxidative stress through a p38 MAPK-mediated antioxidant defense response. Advances in Redox Research. 2022. 6. 100048-100048
Samuel L. Rose, Seiki Baba, Hideo Okumura, Svetlana V. Antonyuk, Daisuke Sasaki, Tobias M. Hedison, Muralidharan Shanmugam, Derren J. Heyes, Nigel S. Scrutton, Takashi Kumasaka, et al. Single crystal spectroscopy and multiple structures from one crystal (MSOX) define catalysis in copper nitrite reductases. Proceedings of the National Academy of Sciences. 2022. 119. 30. e2205664119

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MISC (29)：

櫻井啓介, 山下栄樹, 吉村政人, 長谷川和也, 村上博則, 熊坂崇, 古川行人, 上野剛, 山本雅貴, 中川敦史. SPring-8生体超分子複合体構造解析ビームライン(大阪大学蛋白質研究所)BL44XUの現状. 日本放射光学会年会・放射光科学合同シンポジウム(Web). 2022. 35th
出原啓介, 福井健二, 村川武志, 馬場清喜, 熊坂崇, 内山和久, 矢野貴人. DNAミスマッチ修復系エンドヌクレアーゼであるMutLのATP結合部位におけるリンチ症候群関連の変異はMutLの構造を不安定化させる-A Lynch syndrome-associated mutation at a Bergerat ATP-binding fold destabilizes the structure of the DNA mismatch repair endonuclease MutL. 大阪医科薬科大学医学会雑誌 = Journal of the Medical Association of Osaka Medical and Pharmaceutical University. 2021. 80. 1・2. 85-91
鈴木凌, 小泉晴比古, 平野馨一, 熊坂崇, 小島謙一, 橘勝. タンパク質結晶の動力学的回折効果の観測. KEK Progress Report (Web). 2018. 2018-7. ROMBUNNO.206 (WEB ONLY)
鈴木凌, 小泉晴比古, 小泉晴比古, 平野馨一, 熊坂崇, 小島謙一, 橘勝. タンパク質結晶におけるX線の動力学的回折効果の観測. Photon Factory News. 2018. 36. 3. 8-12
山下恵太郎, 山下恵太郎, 平田邦生, 河野能顕, 上野剛, 長谷川和也, 熊坂崇, 山本雅貴. データ収集・処理の自動化による多数の微小結晶を用いた構造解析の効率化. KEK Proceedings (Web). 2017. 2016-4. 161-163 (WEB ONLY)

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Patents (7)：

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Books (8)：

生体高分子結晶のX線構造解析: -実践手法と基礎理論-
丸善出版 2022 ISBN:4621307061
日本の結晶学(II)ーその輝かしい発展ー
日本結晶学会 2014 ISBN:9784990386122
タンパク質結晶の最前線 = Frontiers of protein crystals
シーエムシー出版 2013 ISBN:9784781309293
バイオ系のための基礎化学問題集 : 生物化学・有機化学・物理化学
講談社サイエンティフィク 2008 ISBN:9784061398214
環境とバイオ [バイオ研究のフロンティア 1]
工学図書 2008 ISBN:9784769204855

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Lectures and oral presentations (130)：

Novel Insights into the Structural Perturbation Induced by the Oncogenic Mutations, Q61L and Q61H, in Ras State 1
(BIOPHYSICAL JOURNAL 2020)
SPring-8タンパク結晶ビームラインにおける自動データ収集システムの現状
(日本放射光学会年会・放射光科学合同シンポジウム(Web) 2020)
理研構造ゲノムビームラインI&IIの現状
(日本放射光学会年会・放射光科学合同シンポジウム(Web) 2020)
SACLA,SPring-8並びにNMRを用いた低分子量Gタンパク質RasのGTP加水分解過程における動的構造解析
(日本分子生物学会年会プログラム・要旨集(Web) 2020)
微小結晶を利用したRas caged-GTP時分割測定の試み
(日本放射光学会年会・放射光科学合同シンポジウム(Web) 2020)

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Education (3)：

1991 - 1996 Tokyo Institute of Technology Graduate School of Bioscience and Bioengineering
1987 - 1991 Tokyo Institute of Technology School of Science
1984 - 1987 Saitama Prefectural Kawagoe High School

Professional career (1)：

Doctor of Science (Tokyo Institute of Technology)

Work history (9)：

2024/04 - 現在 Japan Synchrotron Radiation Research Institute Center for Synchrotron Radiation Research Director
2022/04 - 現在 Japan Synchrotron Radiation Research Institute Structural Biology Division Director
2015/04 - 現在 Kobe University Graduate School of Medicine Visiting Professor
2008 - 現在 Kwansei Gakuin University Graduate School of Science and Technology Visiting Professor
2017/04 - 2022/03 Japan Synchrotron Radiation Research Institute Protein Crystal Analysis Division Director

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Committee career (5)：

2023/04 - 現在日本結晶学会評議員
2021/10 - 2023/09 日本放射光学会渉外幹事
2021/10 - 2023/09 日本放射光学会評議員
2007 - 2009 日本放射光学会編集委員
2006 - 2009 日本結晶学会編集委員

Association Membership(s) (6)：

Japan Society for Bioscience, Biotechnology, and Agrochemistry , Protein Science Society of Japan , The Biophisical Societiy Of Japan , The Japanese Biochemical Society , The Japanese Society for Synchrotron Radiation Research , The Crystallographic Society of Japan

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