Shima Fumi

シマフミ | Shima Fumi

Affiliation and department：
Job title： Professor

Research field (1)： Molecular biology

Research theme for competitive and other funds (32)：

2024 - 2025 Development of Novel PPI inhibitors as anti-cancer drugs
2023 - 2024 新規白血病治療薬の開発
2023 - 2024 Rasシグナルの網羅的阻害を示す革新的がん治療薬の創出を目指した研究
2022 - 2024 Development of Novel PPI inhibitors as anti-cancer drugs
2022 - 2024 Elucidation of cancer signal transduction mechanism using photo-controllable Ras on an atomic scale

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Papers (26)：

Shigeyuki Matsumoto, Haruka Taniguchi-Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Fumi Shima, Takashi Kumasaka, Yasushi Okuno, Tohru Kataoka. Oncogenic mutations Q61L and Q61H confer active form-like structural features to the inactive state (state 1) conformation of H-Ras protein. Biochemical and Biophysical Research Communications. 2021. 565. 85-90
Matsumoto S, Hiraga T, Hayashi Y, Yoshikawa Yoko, Tsuda C, Araki M, Neya M, SHIMA FUMI, Kataoka Tohru. Molecular Basis for Allosteric Inhibition of GTP-Bound H-Ras Protein by a Small-Molecule Compound Carrying a Naphthalene Ring. Biochemistry. 2018. 57. 36. 5350-5358
Yoko Yoshikawa, Osamu Takano, Ichiro Kato, Yoshihisa Takahashi, Fumi Shima, Tohru Kataoka. Ras inhibitors display an anti-metastatic effect by downregulation of lysyl oxidase through inhibition of the Ras-PI3K-Akt-HIF-1 alpha pathway. CANCER LETTERS. 2017. 410. 82-91
Shota Matsunaga, Yuta Hano, Yuta Saito, Kazuhiro J. Fujimoto, Takashi Kumasaka, Shigeyuki Matsumoto, Tohru Kataoka, Fumi Shima, Shigenori Tanaka. Structural transition of solvated H-Ras/GTP revealed by molecular dynamics simulation and local network entropy. JOURNAL OF MOLECULAR GRAPHICS & MODELLING. 2017. 77. 51-63
Tomoyo Okada, Ann Y. Lee, Li-Xuan Qin, Narasimhan Agaram, Takahiro Mimae, Yawei Shen, Rachael O'Connor, Miguel A. Lopez-Lago, Amanda Craig, Martin L. Miller, et al. Integrin-alpha 10 Dependency Identifies RAC and RICTOR as Therapeutic Targets in High-Grade Myxofibrosarcoma. CANCER DISCOVERY. 2016. 6. 10. 1148-1165

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MISC (7)：

Shigeyuki Matsumoto, Haruka Taniguchi-Tamura, Mitsugu Araki, Takashi Kawamura, Ryo Miyamoto, Chiemi Tsuda, Yasushi Okuno, Fumi Shima, Takashi Kumasaka, Tohru Kataoka. Novel Insights into the Structural Perturbation Induced by the Oncogenic Mutations, Q61L and Q61H, in Ras State 1. BIOPHYSICAL JOURNAL. 2020. 118. 3. 42A-42A
佐伯茉帆, 槇野義輝, 松本篤幸, 河村高志, 南後恵理子, 熊坂崇, 島扶美. SACLA,SPring-8並びにNMRを用いた低分子量Gタンパク質RasのGTP加水分解過程における動的構造解析. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
Fumi Shima, Shigeyuki Matsumoto, Yoko Yoshikawa, Takashi Kawamura, Masayuki Isa, Tohru Kataokat. Current status of the development of Ras inhibitors. JOURNAL OF BIOCHEMISTRY. 2015. 158. 2. 91-99
Shima Fumi, 熊坂崇, Matsumoto Shigeyuki, Yoshikawa Yoko, 山本雅貴, Kataoka Tohru. rasがん遺伝子産物の新規立体構造情報を利用した分子標的がん治療薬の開発. 日本放射光学会誌放射光. 2014. 27. 1. 3-9
SHIMA, Fumi, KATAOKA, Toru. 【タンパク質修飾による機能変化】エフェクター活性化過程に必須であるRasの翻訳後修飾 Ras-エフェクター相互作用の高次構造解析. 生化学. 2005. 77巻, 6号, pp.519-526

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Patents (6)：

RasRaf binding inhibitors
Ras機能阻害作用を有するチオキソチアゾリジン誘導体
Ras機能阻害作用を有するチオキソチアゾリジン誘導体(アメリカ)
THIOXOTHIAZOLIDINE DERIVATIVE HAVING RAS FUNCTION INHIBITORY EFFECT
AQUEOUS SOLUTION CONTAING PARTIAL RaS POLYPEPTIDE AND METHOD FOR SCREENING INHIBITOR OF RAS FUNCTION

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Books (2)：

ras がん遺伝子産物 Ras を分子標的としたがん治療薬開発の現状
がん分子標的治療 2015
生化学 / エフェクター活性化過程に必須であるRasの翻訳後修飾
日本生化学会 2005

Lectures and oral presentations (49)：

Recognition mechanism of conformational states in RAS by GTPase-acting protein,GAP
(2023)
Inactivation mechanism og RASelucidated by photoreactive GTP
(The 96th Annual Meeting of the Japanese Biochemical Society 2023)
RAS-signaling inhibitors that allosterically disrupt effector conformation and inhibit growth of RAS-driven cancers
(THE 82ND ANNUAL MEETING OF THE JAPANESE CANCER ASSOCIATION 2023)
低分子量Gタンパク質H-Rasのフリーズトラップ結晶構造解析によるGTPase活性分子メカニズムの追跡
(第95回日本生化学会大会 2022)
SACLA/SPring-8/NMRを駆使した低分子量G蛋白質Rasの不活性化機構におけるアロステリック構造変化の解明
(第95回日本生化学会大会 2022)

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Education (1)：

- 1998 Kobe University Graduate School of Medicine

Professional career (1)：

博士(医学) (神戸大学)

Awards (1)：

2011/06 - 一般社団法人神緑会田中千賀子学術奨励賞女性研究者

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