Ikebukuro Kazunori

Affiliation and department：
Job title： Professor
Other affiliations (4)：

Tokyo University of Agriculture and Technology Faculty of Engineering, Department of Biotechnology and Life Science
Tokyo University of Agriculture and Technology Graduate School of Engineering, Department of Biotechnology and Life Science
Tokyo University of Agriculture and Technology Institute of Global Innovation Research
Tokyo University of Agriculture and Technology Graduate School of Bio-Applications and Systems Engineering

Homepage URL (1)： http://www.tuat.ac.jp/~tanpaku/

Research field (6)： Biomaterials , Biomedical engineering , Applied biofunctional and bioprocess engineering , Biomaterials , Biomedical engineering , Applied biofunctional and bioprocess engineering

Research keywords (6)： Nucleic Acid Engineering , Detection of CpG methylation , Aptamer , Evolutionary molecular engineering , CpG methylation detection , Biosensor

Research theme for competitive and other funds (84)：

2023 - 2026 Development of a nanoplastic detection sensor utilizing DNA as molecular recognition elements.
2023 - 2026 One step electrochemical biosensors based on the proximity among enzyme, antibody and aptamer
2022 - 2025 疾患関連抗体に対する抗イディオタイプDNAアプタマーのファスト&ファインデザイン
2021 - 2023 Development of turn-on fluorescent RNA aptamer to visualize target proteins in vivo
2019 - 2022 Development of analytical technology for proteins in methylome using photo-reacting lignds for guanine quadruplex

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Papers (287)：

Daimei Miura, Saki Motohashi, Ayaka Goto, Hayato Kimura, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Ryutaro Asano. Rapid and Convenient Single-Chain Variable Fragment-Employed Electrochemical C-Reactive Protein Detection System. International Journal of Molecular Sciences. 2024
Daimei Miura, Saki Motohashi, Ayaka Goto, Hayato Kimura, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Ryutaro Asano. Rapid and Convenient Single-Chain Variable Fragment-Employed Electrochemical C-Reactive Protein Detection System. International Journal of Molecular Sciences. 2024
Erika Komiya, Shouhei Takamatsu, Daimei Miura, Kaori Tsukakoshi, Wakako Tsugawa, Koji Sode, Kazunori Ikebukuro, Ryutaro Asano. Exploration and Application of DNA-Binding Proteins to Make a Versatile DNA-Protein Covalent-Linking Patch (D-Pclip): The Case of a Biosensing Element. Journal of the American Chemical Society. 2024
Yuri Numaguchi, Kaori Tsukakoshi, Nanami Takeuchi, Yuki Suzuki, Kazunori Ikebukuro, Ryuji Kawano. Real-time monitoring of the amyloid β1-42 monomer-to-oligomer channel transition using a lipid bilayer system. PNAS nexus. 2024. 3. 1. pgad437
Kenichiro Todoroki, Daichi Hamada, Tomohiro Yamada, Taro Saito, Yutaka Shimizu, Eiji Sugiyama, Hajime Mizuno, Hideki Hayashi, Kaori Tsukakoshi, Kazunori Ikebukuro. Development of a liquid chromatography-based versatile bioanalysis for bevacizumab based on pretreatment combining aptamer affinity purification and centrifugal ultrafiltration concentration. Analytical sciences : the international journal of the Japan Society for Analytical Chemistry. 2023

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MISC (330)：

後藤悠見, 柴田京華, 塚越かおり, 池袋一典, 長谷川成人, 尾上靖宏, 小椋光, 奥野貴士, KAMPINGA Harm, BERGINK Steven, et al. 単独でシヌクレイン線維を脱会合できる分子CtHsp104の同定とそのメカニズムの解析. 日本蛋白質科学会年会プログラム・要旨集. 2021. 21st
葛西豪太, 浅野竜太郎, 池袋一典, 早出広司. Study on improvement of expression of a small cancer therapeutic bispecific antibody in Synechocystis sp. PCC 6803. 日本化学会春季年会講演予稿集(Web). 2021. 101st
前島敦, 石橋健太, 池袋一典, KIM Hyonchol, KIM Hyonchol, 熊谷泉, 浅野竜太郎. Evaluation of intercellular cross-linking abilities of bispecific antibodies with different cytotoxicities using AFM force-sensing. 日本化学会春季年会講演予稿集(Web). 2021. 101st
葛西豪太, 小林俊一, 池袋一典, 早出広司, 浅野竜太郎. Synechocystis sp.PCC 6803を生産宿主とした低分子二重特異性がん治療抗体の生産量の向上を目指した検討. マリンバイオテクノロジー学会大会講演要旨集. 2021. 21st
塚越かおり, 沼口友理, 清水啓佑, 川野竜司, 池袋一典. チャネル電流計測法を用いた脂質膜上におけるAβのポア構造形成過程の解析. Dementia Japan. 2020. 34. 4

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Patents (80)：

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Books (18)：

酵素活性を増強させるDNAアプタマーの開発 --新しいバイオセンサー,生命現象の制御因子への応用を目指して
化学化学同人 2022
進化を続ける核酸化学 : ゲノム編集、非二重らせん、核酸医薬
化学同人 2021 ISBN:9784759814019
核酸科学ハンドブック
講談社 2020 ISBN:9784065207864
Chemical, gas, and biosensors for internet of things and related applications
Elsevier 2019 ISBN:9780128154090
「アプタマーの医療応用」CSJカレントレビュー24 化学で医療・診断・創薬の革新を目指す
医療・診断・創薬の化学 -医療分野に挑む革新的な化学技術-、日本化学会編、化学同人(2017)、p55-63. 2017

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Lectures and oral presentations (254)：

“Aptameric enzyme subunit for homogeneous detection enabling in situ detection”
(2022 KSBB Fall Meeting and International Symposium, Jeju, Korea 2022)
アプタマーと抗体によるウイルスを光らせて直接見る技術の開発
(日本化学会第103春季年会(2023) イノベーション共創プログラム(CIP) » 感染症を診断・予防するヘルスケアテクノロジー 2023)
“Computer aided evolution of the desired functions of peptide/DNA aptamers”
(The third International Workshop on Symbiosis of Biology and Nanodevices, Nara Kasugano International Forum, Nara, Japan 2019)
Smart aptamer: the aptamer changing its structure and function depending on the environmental condition
(2019)
Smart aptamers forming G-quadruplex: Structural and functional change of aptamers forming G-quadruplex in response to surrounding conditions and its regulation with the ligands
(256th ACS National Meeting 2018)

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Works (34)：

光熱変換とアプタマーを用いた標的タンパク質検出法の開発
2009 - 2010
臨床診断技術に関する研究
2008 - 2009
平成20年度東京都重点戦略プロジェクト支援事業「超高齢化都市のモデルに対応する有害微生物・ウイルスの複数・迅速・検出装置」
2008 - 2009
光熱変換とアプタマーを用いた標的タンパク質検出法の開発
2008 - 2009
変形アプタマーによる酵素捕捉を利用した超高感度センシングシステムの開発
2008 - 2009

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Education (4)：

1992 - 1993 The University of Tokyo Graduate School, Division of Engineering
1989 - 1992 The University of Tokyo Graduate School, Division of Engineering 合成化学専攻
1990 - 1991 Cranfield Institute of Technology British Council Fellowship
1985 - 1989 The University of Tokyo Faculty of Engineering 工業化学科

Professional career (1)：

博士(工学) (東京大学)

Work history (4)：

2009/04 - - 東京農工大学大学院工学研究院
2001/04 - - 東京農工大学工学部助教授
1996/04 - 2001/03 - 東京大学先端科学技術研究センター講師
1993/04 - 1996/03 - 東京大学先端科学技術研究センター助手

Committee career (4)：

2019/05 - 現在 Biosensors and Bioelectronics, Associate Editor
2019 - 現在 Encyclopedia for Sensors and Biosensors, Elsevier, Section Editor
2017/11 - 現在日本核酸化学会評議員
2000 - 日本化学会化学と工業編集委員

Awards (6)：

2018/05 - Elesevier Biosensors & Bioelectronics Best Paper Award, Runners Up Designer fungus FAD glucose dehydrogenase capable of direct electron transfer
2012/10/05 - (財)バイオインダストリー協会化学素材研究開発振興財団記念基金グラント研究奨励金「酵素-アプタマー複合体のナノ構造変化を利用したC反応性蛋白質の高感度検出法の開発」
2008/05/15 - Elsevier and Biosensors 2008 The Elsevier Biosensors & Bioeletronics Award 2008, 2nd Prize
2006 - JSPS Japanese-American Frontiers of Sciences これまでの研究業績
2005 - NSF/MEXT U.S. - JAPAN YOUNG SCIENTISTS SYMPOSIUM ON BIONANOTECHNOLOGY

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Association Membership(s) (5)：

Japan Society of Nucleic Acids Chemistry , 日本化学会 , 日本分子生物学会 , The Society for Biotechnology , 電気化学会生物工学研究会

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