Totoribe Naoko

トトリベナオコ | Totoribe Naoko

Affiliation and department：

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (6)：生活習慣病 , 下肢静脈瘤 , バイパス血管 , 糖尿病 , ヒト血管 , 血管薬理

Research theme for competitive and other funds (5)：

2017 - 2020 下肢静脈瘤の初期進展におよぼす血管機能破綻メカニズムの解明
2011 - 2013 Usefulness of the Rho/Rho kinase inhibitor to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus
2009 - 2010 Pharmacological studies on responsiveness of 5-hydroxytryptamine to overcome perioperative spasm of coronary artery bypass graft in diabetes mellitus
2007 - 2008 Pharmacological studies on responsiveness of 5-hydroxytryptamin to overcome perioperative spasm of coronary artery bypass graft
血管内皮細胞におけるATP遊離機構に関する研究

Papers (48)：

Naoko Tanaka-Totoribe, Muneaki Hidaka, Shuji Gamoh, Atsuko Yokota, Eisaku Nakamura, Masachika Kuwabara, Jun Tsunezumi, Ryuichi Yamamoto. Effects of M-1, a Major Metabolite of Sarpogrelate, on 5-HT-Induced Constriction of Isolated Human Internal Thoracic Artery. Biol Pharm Bull. 2020. 1. 43. 1979-1982
Shiba Tatsuo, Totoribe Naoko, Gamoh Shuji, Yokota Atsuko, Nakamura Eisaku, Kuwabara Masachika, Hisa Hiroaki, Yamamoto Ryuichi. The effect of M-1, a major metabolite of sarpogrelate, on 5-hydroxytryptamine-mediated vasoconstriction in isolated human internal thoracic artery. Proceedings for Annual Meeting of The Japanese Pharmacological Society. 2019. 92. 1-P-067
Shiba T, Yokota A, Gamoh S, Tanaka-Totoribe N, Kuwabara M, Nakamura E, Hayase T, Nakamura K, Yamamoto R. Diabetes mellitus induces hyperreactivity of 5-hydroxytryptamine (5-HT)-induced constriction in human internal thoracic artery and is associated with increase in the membrane protein level of 5-HT2A receptor. Biological and Pharmaceutical Bulletin. 2018. 41. 1-5
Yokota A, Gamoh S, Tanaka-Totoribe N, Shiba T, Kuwabara M, Nakamura E, Hayase T, Hisa H, Nakamura K, Yamamoto R. Angiotensin II, as well as 5-hydroxytriptamine, is a potent vasospasm inducer of saphenous vein graft for coronary artery bypass grafting in patients with diabetes mellitus. Biochemistry and Biophysics Reports. 2016. 6. 82-87
Shuji Gamoh, Tasuku Kanai, Naoko Tanaka-Totoribe, Masamichi Ohkura, Masachika Kuwabara, Eisaku Nakamura, Atsuko Yokota, Tetsuo Yamasaki, Akiko Watanabe, Masahiro Hayashi, et al. Water-soluble jack-knife prawn extract inhibits 5-hydroxytryptamine-induced vasoconstriction and platelet aggregation in humans. Food & function. 2015. 6. 2. 444-9

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MISC (29)：

Tasuku Kanai, Shuji Gamoh, Naoko Totoribe, Masachika Kuwabara, Eisaku Nakamura, Hiroaki Hisa, Ryuichi Yamamoto. Exendin-4, a glucagon-like peptide-1 analogue, inhibits 5-hydroxytryptamine-induced vasocontraction in the isolated human endothelium-denuded saphenous vein. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2013. 121. 204P-204P
Yasuko Matsuo, Masachika Kuwabara, Naoko Totoribe, Tasuku Kanai, Eisaku Nakamura, Shuji Gamoh, Akito Suzuki, Yujiro Asada, Hiroaki Hisa, Ryuichi Yamamoto. The decrease in the protein level of myosin light chain phosphatase in isolated saphenous vein harvested from patients with diabetes mellitus. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2012. 118. 202P-202P
Tasuku Kanai, Yasuko Matuo, Naoko Tanaka, Masachika Kuwabara, Eisaku Nakamura, Hiroaki Hisa, Ryuichi Yamamoto. Insulin-induced NO-independent vasodilation in the human endothelium-denuded saphenous vein. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2011. 115. 107P-107P
Naoko Tanaka, Tasuku Kanai, Yasuko Matsuo, Masachika Kuwabara, Eisaku Nakamura, Kunihide Nakamura, Yujiro Asada, Hiroaki Hisa, Ryuichi Yamamoto. Relative contributions of Rho-kinase to the constrictions of human isolated internal thoracic artery and saphenous vein. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2010. 112. 85P-85P
Namie Nejime, Naoko Tanaka, Satomi Kagota, Yukari Tada, Kazuki Nakamura, Michio Hashimoto, Masaru Kunitomo, Kazumasa Shinozuka. Cancer cells modulate the intracellular macromolecular permeability in the human umbilical vein endothelial cell layer via P2 receptor. JOURNAL OF PHARMACOLOGICAL SCIENCES. 2009. 109. 290P-290P

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Lectures and oral presentations (91)：

ヒト冠動脈バイパス内胸動脈グラフトのれん縮を予防するパパベリンの至適濃度について
(日本薬学会第142年会 2022)
Google driveを利用した自己学習支援システムの構築
(第6回日本薬学教育学会大会)
冠動脈バイパス手術(CABG)における内胸動脈バイパスグラフトの血管れん縮を予防するパパベリンの至適濃度の検討
(日本薬学会第141年会 2021)
ラット摘出腸管血管灌流標本において、麻薬拮抗薬であるナロキソンは血管平滑筋 extra-junctional α1 受容体を抑制するが intra-junctional α1 受容体には作用しない,
(日本薬学会第140年会 2020)
末梢血管疾患の改善を目指したヒト摘出血管の薬理学的検討
(第1回宮崎県北サイエンスフォーラム 2019)

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Education (3)：

- 1999 Mukogawa Women's University Graduate School, Division of Pharmaceutical Sciences
- 1997 Mukogawa Women's University School of Pharmacy and Pharmaceutical Sciences
- 1997 Mukogawa Women's University Faculty of Pharmaceutical Science

Professional career (1)：

(BLANK) (Mukogawa Women's University)

Work history (6)：

2022/04 - 現在 Kyushu University of Health and Welfare School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2012/04 - 2022/03 Kyushu University of Health and Welfare School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2007/07 - 2012/03 Kyushu University of Health and Welfare School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2007/04 - 2007/06 Kyushu University of Health and Welfare School of Pharmaceutical Sciences Department of Pharmaceutical Sciences
2004/04 - 2007/03 Kyushu University of Health and Welfare School of Pharmaceutical Sciences Department of Pharmaceutical Sciences

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Awards (3)：

2009/03 - 第5回高梁学園学術研究コンファレンス研究部門創立者加計勉賞受賞
2008/12 - 日本薬学会九州支部学術奨励賞
2004/05 - Life style Related Diseases -Perspectives for Primary Prevention and Treatment in Animal Models and Humans -, 2004, Spokane, WA, USA Young Investigator Award

Association Membership(s) (3)：

日本薬学会 , 日本薬理学会 , 日本心脈管作動物質学会

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