Fujii Mikio

フジイミキオ | Fujii Mikio

Affiliation and department：
Job title：准教授

Research field (1)： Pharmaceuticals - chemistry and drug development

Research keywords (4)： Chemistry of Coenzyme , natural product chemistry , Chemistry of Biocatalyst , 有機化学

Research theme for competitive and other funds (4)：

2011 - 2013 Development of coenzyme with enzyme selectivity and substrate-coenzyme complex inhibitor
2009 - 2011 Development of new reaction by using bis(oxazoline) ligands.
生体触媒を利用した天然物合成
Synthesis of Natural Products by Using Biocatalysis

Papers (51)：

Koichi Sugimoto, Eiichiro Ono, Tamaki Inaba, Takehiko Tsukahara, Kenji Matsui, Manabu Horikawa, Hiromi Toyonaga, Kohki Fujikawa, Tsukiho Osawa, Shunichi Homma, et al. Identification of a tomato UDP-arabinosyltransferase for airborne volatile reception. Nature Communications. 2023. 14. 1
Michio Takagi, Kotchakorn T. Sriwong, Ayaka Masuda, Nozomi Kawaguchi, Shusuke Fukui, Lan Huong Le Viet, Dai-Ichiro Kato, Takashi Kitayama, Mikio Fujii, Afifa Ayu Koesoema, et al. Immobilization of Baeyer-Villiger monooxygenase from acetone grown Fusarium sp. BIOTECHNOLOGY LETTERS. 2022
Fujii Mikio, Kuramochi Taiki, Nakakuki Yuhi, Hatazawa Rina, Konno Kiju, Munakata Tatsuo, Hirai Yasuaki. Synthesis of gentianine N-oxide by enzymatic hydrolysis of swertiamarin in the presence of hydroxylamine and reaction pathway to gentianine and gentianol. TETRAHEDRON LETTERS. 2019. 60. 10. 721-725
FUJII Mikio. Introduction of Team-Based Learning (TBL) into Chemistry Class: training of problem solving ability through active learning. 国際医療福祉大学学会誌. 2018. 23. 1. 16-27
Mikio Fujii, Hidehiro Ando, Kiju Konno, Motonori Fukumura, Yumiko Hori, Yasuaki Hirai, Yoshiteru Ida. Structural Revision of a Naphthodipyranodione from Gentian Root and its Degradation Pathway from Gentiopicroside. NATURAL PRODUCT COMMUNICATIONS. 2017. 12. 3. 395-397

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MISC (59)：

藤井幹雄, 村田侑生, 若林諒. Conformational analysis of flavine ring in enzyme-FAD complex. 日本薬学会年会要旨集(Web). 2023. 143rd
藤井幹雄. ゲンチアニンN-オキシドへの置換基導入法の検討. 国際医療福祉大学学会誌. 2022. 27
村田侑生, 若林諒, 藤井幹雄. Verification of enzyme taxonomy by dihedral angle θof diphosphate in flavin adenine dinucleotide (FAD). 日本薬学会年会要旨集(Web). 2022. 142nd
穴原良記, 中久喜勇飛, 倉持大樹, 野口貴矢, 平井康昭, 藤井幹雄. Study of environmentally-friendly pyridine ring formation by enzymatic hydrolysis of gentiopicroside abundantly supplied from Gentian. 日本薬学会年会要旨集(Web). 2022. 142nd
藤井幹雄, 野口貴矢, 柿沼里優, 平井康昭. Deoxygenation and functionalization of gentianine N-oxide by a long-range substitutio. 日本薬学会年会要旨集(Web). 2021. 141st

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Books (9)：

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Lectures and oral presentations (84)：

Study on cell-penetrating coenzymes NAD and FAD: How to modify the function of diphosphate on coenzyme.
(生体触媒化学シンポジウム講演要旨集 2018)
Chemoenzymatic synthesis of gentianine N-oxide from gentiopicroside and swertiamarin and the reaction pathways
(生体触媒化学シンポジウム講演要旨集 2018)
補酵素NADの配座固定型阻害剤の合成とグルタチオン還元酵素に対する阻害様式について
(日本化学会春季年会講演予稿集(CD-ROM) 2018)
膜透過型FADの合成研究
(国際医療福祉大学学会誌 2018)
スウェルチアマリンのヒドロキシルアミン存在下での酵素加水分解に関する研究
(生体触媒化学シンポジウム講演要旨集 2017)

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Works (1)：

Professional career (2)：

Work history (2)：

Committee career (1)：

Association Membership(s) (5)：

日本化学会 , 有機合成化学協会 , 日本薬学会 , JAPANESE SOCIETY FOR CHEMICAL BIOLOGY , 日本薬学教育学会

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