Rchr
J-GLOBAL ID：200901096944876761
Update date: Feb. 17, 2024
Shiraki Nobuaki
シラキ ノブアキ | Shiraki Nobuaki
Affiliation and department：
Job title：
Associate Professor
Research field (3)：
Metabolism and endocrinology
, Developmental biology
, Nutrition and health science
Research keywords (9)：
小腸
, 肝臓
, メチオニン
, 亜鉛
, 膵臓
, iPS細胞
, ES細胞
, アミノ酸
, 微量元素
Research theme for competitive and other funds (11)：
- 2021 - 2024 食による体質リライトおよび疾患リスク低減に関する研究基盤の構築
- 2019 - 2022 Mechanistic study on defects in pancreatic beta-cell function, and its prevention by food factors
- 2018 - 2021 Development of Novel Generation of Nutritional Environmental Risk Assessment System Using Human iPS Cells
- 2016 - 2019 Research on innovative cell transplantation device using immunoisolation membrane
- 2015 - 2017 Development of novel multi-target drugs for intractable amyloidoses
- 2014 - 2017 The verification of the fetal origins of adult disease theory using human iPS cell pancreatic differentiation system
- 2013 - 2016 Establishment of hepatocyte model from induced pluripotent stem (iPS) cells for exploring uremic toxin production inhibitors
- 2014 - 2015 Identification of hepatic maturation mechanisms of human iPS cells by using chemical screening
- 2009 - 2011 Hepatocyte replacement therapy for familial amybidotic polyneuropathy combining iPS cells and gene-repair therapy
- 2009 - 2010 Establishment of intestinal differentiation method from ES/iPS cells
- 2007 - 2008 The establishment of efficient method for differentiation towards pancreatic beta cells from ES cells
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Papers (67)：
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Dhimas Agung Kurniawan, Sylvia Leo, Mutsumi Inamatsu, Sohei Funaoka, Taichi Aihara, Mizuno Aiko, Inoue Rei, Takeshi Sakura, Hiroshi Arakawa, Yukio Kato, et al. Gut-liver microphysiological systems revealed potential crosstalk mechanism modulating drug metabolism. PNAS Nexus. 2024
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Kenta Ouchi, Kaori Isono, Yuki Ohya, Nobuaki Shiraki, Masayoshi Tasaki, Yukihiro Inomata, Mitsuharu Ueda, Takumi Era, Shoen Kume, Yukio Ando, et al. Characterization of heterozygous ATTR Tyr114Cys amyloidosis-specific induced pluripotent stem cells. Heliyon. 2024. 10. 2. e24590
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Hiraku Tokuma, Daisuke Sakano, Katsuya Tanabe, Yukio Tanizawa, Nobuaki Shiraki, Shoen Kume. Selective proteasome degradation of C-terminally-truncated human WFS1 in pancreatic beta cells. FEBS open bio. 2023. 13. 8. 1405-1414
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Sylvia Leo, Yusuke Kato, Yu Meng Wu, Mutsumi Yokota, Masato Koike, Shiro Yui, Kiichiro Tsuchiya, Nobuaki Shiraki, Shoen Kume. The effect of Vitamin D3 and Valproic Acid on the maturation of human induced pluripotent stem cell-derived enterocyte-like cells. Stem cells (Dayton, Ohio). 2023
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Hiroki Ozawa, Azusa Kambe, Kodai Hibi, Satoshi Murakami, Akira Oikawa, Tetsuya Handa, Katsunori Fujiki, Ryuichiro Nakato, Katsuhiko Shirahige, Hiroshi Kimura, et al. Transient Methionine Deprivation Triggers Histone Modification and Potentiates Differentiation of Induced Pluripotent Stem Cells. Stem Cells. 2023
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MISC (121)：
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白木伸明, 粂昭苑. Control of stem cell differentiation through regulation of methionine metabolism. 日本再生医療学会総会(Web). 2022. 21st
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白木伸明, ERINN Sim Zixuan, 榎本孝幸, 古田奈央, 樫尾宗志朗, 神戸大朋, 津山友徳, 荒川哲大, 小澤弘樹, 横山水穂, et al. Methionine metabolism regulates pluripotent stem cell through zinc mobilization. Biomedical Research on Trace Elements (Web). 2022. 33. 1
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白木伸明. Nutrition and cell differentiation. 生化学. 2021. 93. 1
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石部隆之介, SYLVIA Leo, 渡邊輝彦, 白木伸明, 粂昭苑. 吸収腸上皮細胞への分化を促進する低分子化合物のスクリーニング. 日本再生医療学会総会(Web). 2021. 20th
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稲村恒亮, 三ツ田愛美, 木村啓志, 前川敏郎, 川田大輝, 河西巧, 荒川大, 加藤将夫, 白木伸明, 粂昭苑, et al. iPS細胞由来腸管細胞を搭載したMPSデバイスの開発とin vitro評価. 日本再生医療学会総会(Web). 2021. 20th
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Patents (22)：
Work history (1)：
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