Rchr
J-GLOBAL ID：201201045014887480   Update date: Apr. 12, 2024

Uchimura Kenji

ウチムラ ケンジ | Uchimura Kenji
Affiliation and department：
CNRS Université de Lille

About CNRS Université de Lille


Job title： Research Director
Research field  (1)： Medical biochemistry
Research keywords  (7)： プロテオグリカン ,  包括脳ネットワーク ,  硫酸転移酵素 ,  スルファターゼ ,  細胞接着分子 ,  糖鎖 ,  セレクチン
Research theme for competitive and other funds  (8)：
  • 2017 - 2020 Functional analysis of sulfated glycans in ductular reactions
  • 2017 - 2019 血管内皮障害を呈する腎疾患におけるSulf2の機能解析と新たな治療戦略の探求
  • 2015 - 2018 Sulf2-remodeling of heparan sulfate present in brain amyloids
  • 2015 - 2017 Roles of sulfated N-glycans in myelin
  • 2017 - 2017 脳アミロイド斑除去に関わるミクログリアの糖鎖改変による機能制御機構の解明(国際共同研究強化)
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Papers (91)：
  • Yoshiko Takeda-Uchimura, Midori Ikezaki, Tomoya O Akama, Yoshito Ihara, Fabrice Allain, Kazuchika Nishitsuji, Kenji Uchimura. GlcNAc6ST2/CHST4 Is Essential for the Synthesis of R-10G-Reactive Keratan Sulfate/Sulfated N-Acetyllactosamine Oligosaccharides in Mouse Pleural Mesothelium. Molecules (Basel, Switzerland). 2024. 29. 4
  • Yuki Takechi-Haraya, Takashi Ohgita, Akiko Usui, Kazuchika Nishitsuji, Kenji Uchimura, Yasuhiro Abe, Ryuji Kawano, Monika I. Konaklieva, Mart Reimund, Alan T. Remaley, et al. Structural flexibility of apolipoprotein E-derived arginine-rich peptides improves their cell penetration capability. 2023
  • Bilal Hussain, Vivek Kasinath, Gabriel P. Ashton-Rickardt, Thomas Clancy, Kenji Uchimura, George Tsokos, Reza Abdi. High endothelial venules as potential gateways for therapeutics. Trends in Immunology. 2022. 43. 9. 728-740
  • Naoyuki Iwahashi, Midori Ikezaki, Yoshihiro Komohara, Yukio Fujiwara, Tomoko Noguchi, Kaho Nishioka, Kazuko Sakai, Kazuto Nishio, Mitsuharu Ueda, Yoshito Ihara, et al. Cytoplasmic p53 aggregates accumulated in p53-mutated cancer correlate with poor prognosis. PNAS Nexus. 2022. 1. 3. pgac128
  • Kenji Uchimura, Kazuchika Nishitsuji, Li-Ting Chiu, Takashi Ohgita, Hiroyuki Saito, Fabrice Allain, Veeranjaneyulu Gannedi, Chi-Huey Wong, Shang-Cheng Hung. Design and Synthesis of 6-O-Phosphorylated Heparan Sulfate Oligosaccharides to Inhibit Amyloid β Aggregation. Chembiochem : a European journal of chemical biology. 2022. 23. 15. e202200191
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MISC (60)：
  • 西辻和親, 池崎みどり, 内村健治, 内村健治, 岩橋尚幸, 西岡香穂, 藤原章雄, 菰原義弘, 井箟一彦, 井原義人. Sulfated glycosaminoglycan-mediated spreading of p53 amyloid and its contribution to cancer pathology. 日本糖質学会年会要旨集. 2022. 41st
  • 池崎みどり, 西辻和親, 眞鍋史乃, 眞鍋史乃, 内村健治, 内村健治, 伊藤幸成, 伊藤幸成, 井原義人. C-Mannosylated peptide attenuates astrocyte-induced synaptogenesis in rat cortical neurons. 日本糖質学会年会要旨集. 2022. 41st
  • 池崎 みどり, 西辻 和親, 眞鍋 史乃, 内村 健治, 伊藤 幸成, 井原 義人. C-マンノシル化WSPWペプチドはTGF-βシグナル抑制を介してアストロサイト培養上清によるシナプス形成を阻害する. 日本生化学会大会プログラム・講演要旨集. 2021. 94回. [P-006]
  • 西川 太朗, 岩橋 尚幸, 池崎 みどり, 井原 義人, 井箟 一彦, 内村 健治, 西辻 和親. p53変異型癌におけるp53凝集体沈着と伝播機構. 日本病理学会会誌. 2021. 110. 1. 378-378
  • 西辻和親, 内村健治. Contribution of Sulfated Glycosaminoglycans to the Pathology of Amyloidosis. Trends in Glycoscience and Glycotechnology (Web). 2021. 33. 196
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Patents (6)：
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Education (1)：
  • 1996 - 1999 Nagoya University Graduate School of Medicine
Professional career (1)：
  • 博士(医学) (名古屋大学)
Work history (5)：
  • 2018 - 現在 Unité de Glycobiologie Structurale et Fonctionnelle, CNRS UMR 8576, Université de Lille
  • 2011 - 2018 Nagoya University Graduate School of Medicine Associate Professor
  • 2006 - 2011 National Center for Geriatrics and Gerontology Section Chief
  • 2001 - 2006 University of California San Francisco Department of Anatomy, Program in Immunology
  • 1999 - 2001 Nagoya University School of Medicine JSPS Research Fellow
Awards (2)：
  • 2011 - Young Investigator Award of Japanese Society of Biochemistry
  • 2006 - Young Investigator Award of Japanese Society of Carbohydrate Research
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