安川孝史

Yasukawa Takashi

所属機関・部署：

研究分野 (1件)：分子生物学

競争的資金等の研究課題 (7件)：

2021 - 2024 新規アルツハイマー病治療薬創出に向けたNRBP1-ユビキチンリガーゼ阻害剤の探索
2018 - 2021 新規ユビキチンリガーゼを標的とするアルツハイマー病の治療薬開発に向けた基盤研究
2015 - 2018 神経分化における伸長因子Elongin Aの標的遺伝子の探索とその制御機構の解明
2012 - 2015 E3活性を併せ持つ伸長因子Elongin Aの発生・神経形成における機能の解明
2009 - 2011 転写伸長因子Elongin Aの発生・神経分化における役割の解明

全件表示

論文 (30件)：

Takashi Yasukawa, Aya Tsutsui, Chieri Tomomori-Sato, Shigeo Sato, Anita Saraf, Michael P. Washburn, Laurence Florens, Tohru Terada, Kentaro Shimizu, Ronald C. Conaway, et al. NRBP1-Containing CRL2/CRL4A Regulates Amyloid β Production by Targeting BRI2 and BRI3 for Degradation. Cell Reports. 2020. 30. 10. 3478-3491
Juston C. Weems, Brian D. Slaughter, Jay R. Unruh, Stefan Boeing, Shawn M. Hall, Merry B. McLaird, Takashi Yasukawa, Teijiro Aso, Jesper Q. Svejstrup, Joan W. Conaway, et al. Cockayne syndrome B protein regulates recruitment of the Elongin A ubiquitin ligase to sites of DNA damage. JOURNAL OF BIOLOGICAL CHEMISTRY. 2017. 292. 16. 6431-6437
Nakazawa H, Chang K, Shinozaki S, Yasukawa T, Ishimaru K, Yasuhara S, Yu YM, Martyn JA, Tompkins RG, Shimokado K, et al. iNOS as a Driver of Inflammation and Apoptosis in Mouse Skeletal Muscle after Burn Injury: Possible Involvement of Sirt1 S-Nitrosylation-Mediated Acetylation of p65 NF-κB and p53. PloS one. 2017. 12. 1. e0170391
Juston C. Weems, Brian D. Slaughter, Jay R. Unruh, Shawn M. Hall, Merry B. McLaird, Joshua M. Gilmore, Michael P. Washburn, Laurence Florens, Takashi Yasukawa, Teijiro Aso, et al. Assembly of the Elongin A Ubiquitin Ligase Is Regulated by Genotoxic and Other Stresses. JOURNAL OF BIOLOGICAL CHEMISTRY. 2015. 290. 24. 15030-15041
Junya Kawauchi, Makoto Inoue, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald C. Conaway, Joan W. Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional Properties of Mammalian Elongin A and Its Role in Stress Response. JOURNAL OF BIOLOGICAL CHEMISTRY. 2013. 288. 34. 24302-24315

MISC (6件)：

Makoto Inoue, Junya Kawauchi, Mizue Fukuda, Yohei Uchida, Takashi Yasukawa, Ronald Conaway, Joan Conaway, Teijiro Aso, Shigetaka Kitajima. Transcriptional properties of mammalian Elongin A and its role in stress response. FASEB JOURNAL. 2014. 28. 1
Teijiro Aso, Takumi Kamura, Shigetaka Kitajima, Ronald C. Conaway, Joan W. Conaway, Takashi Yasukawa. Mammalian Elongin A complex mediates DNA-damage-induced ubiquitylation and degradation of Rpb1. FASEB JOURNAL. 2009. 23
T Yasukawa, M Kaneki, S Yasuhara, JAJ Martyn. Steroidal nondepolarizing muscle relaxants do not simulate the effects of glucocorticoids on glucocorticoid receptor-mediated transcription in cultured skeletal muscle cells. CRITICAL CARE MEDICINE. 2003. 31. 12. A38-A38
M Kaneki, E Tokunaga, H Sugita, T Yasukawa, J Martyn. S-nitrosylation-mediated inactivation ofAkt/PKB in cultured cells and diabetic (db/db) mice. DIABETES. 2003. 52. A289-A290
Y Hashimoto, T Niikura, H Tajima, T Yasukawa, H Sudo, Y Ito, Y Kita, M Kawasumi, K Kouyama, M Doyu, et al. A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer's disease genes and A beta (vol 98, pg 6336, 2001). PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA. 2001. 98. 22. 12854-12854

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