文献

J-GLOBAL ID：201602242478222626   整理番号：16A0906094

siRNAデリバリーに対するsiRNA負荷小サイズ脂質ナノ粒子の物理化学的性質および活性の解明

Elucidation of the physicochemical properties and potency of siRNA-loaded small-sized lipid nanoparticles for siRNA delivery

著者 (10件)： Sato Yusuke (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Note Yusuke (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan) ,  Maeki Masatoshi (Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan) ,  Kaji Noritada (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Kaji Noritada (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Baba Yoshinobu (Department of Applied Chemistry, Graduate School of Engineering, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Baba Yoshinobu (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Tokeshi Manabu (Division of Applied Chemistry, Faculty of Engineering, Hokkaido University, Kita 13 Nishi 8, Kita-ku, Sapporo 060-8628, Japan) ,  Tokeshi Manabu (ImPACT Research Center for Advanced Nanobiodevices, Nagoya University, Furo-cho, Chikusa-ku, Nagoya 464-8603, Japan) ,  Harashima Hideyoshi (Faculty of Pharmaceutical Sciences, Hokkaido University, Kita 12 Nishi 6, Kita-ku, Sapporo 060-0812, Japan)
資料名： Journal of Controlled Release  (Journal of Controlled Release)
巻： 229  ページ： 48-57  発行年： 2016年05月10日 
JST資料番号： C0308D  ISSN： 0168-3659  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： オランダ (NLD)  言語： 英語 (EN)

抄録/ポイント： 50nm以下の直径のナノ粒子は,間質の多い腫瘍組織により効果...

シソーラス用語： *遺伝子導入 ,...
準シソーラス用語： *siRNAデリバリー ,...

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著者キーワード (6件)： Small-sized lipid nanoparticles ,  siRNA delivery ,  Microfluidic device ,  Protein adsorption ,  Stability ,  Endosomal escape

分類 (3件)： 遺伝子操作  (EC02050B) ,  医用素材  (GA05040H) ,  腫ようの実験的治療  (GE02040Y)

引用文献 (34件)：

• M. Jayaraman, S.M. Ansell, B.L. Mui, Y.K. Tam, J. Chen, X. Du, D. Butler, L Eltepu, S. Matsuda, J.K. Narayanannair, K.G. Rajeev, I.M. Hafez, A. Akinc, M.A. Maier, M.A. Tracy, P.R. Cullis, T.D. Madden, M. Manoharan, M.J. Hope, Maximizing the potency of siRNA lipid nanoparticles for hepatic gene silencing in vivo, Angew Chem Int Ed Engl 51 (2012) 8529-8533.
• C.I. Wooddell, D.B. Rozema, M. Hossbach, M. John, H.L Hamilton, Q Chu, J.O. Hegge, J.J. Klein, D.H. Wakefield, C.E. Oropeza, J. Deckert, I. Roehl, K. Jahn-Hofmann, P. Hadwiger, H.P. Vornlocher, A. McLachlan, D.L. Lewis, Hepatocyte-targeted RNAi therapeutics for the treatment of chronic hepatitis B virus infection, Mol. Ther. 21 (2013) 973-985.
• J.K. Nair, J.L. Willoughby, A. Chan, K. Charisse, M.R. Alam, Q Wang, M. Hoekstra, P. Kandasamy, A.V. Kel'in, S. Milstein, N. Taneja, J. O'Shea, S. Shaikh, L Zhang, RJ. van der Sluis, M.E. Jung, A. Akinc, R. Hutabarat, S. Kuchimanchi, K. Fitzgerald, T. Zimmermann, TJ. van Berkel, M.A. Maier, K.G. Rajeev, M. Manoharan, Multivalent N-acetylgalactosamine-conjugated siRNA localizes in hepatocytes and elicits robust RNAi-mediated gene silencing, J. Am. Chem. Soc. 136 (2014) 16958-16961.
• Y. Matsumura, H. Maeda, A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs, Cancer Res. 46 (1986) 6387-6392.
• H. Maeda, T. Sawa, T. Konno, Mechanism of tumor-targeted delivery of macromolecular drugs, including the EPR effect in solid tumor and clinical overview of the prototype polymeric drug SMANCS, J. Control. Release 74 (2001) 47-61.

タイトルに関連する用語 (6件)： siRNAデリバリー ,  siRNA ,  小サイズ ,  脂質ナノ粒子 ,  物理化学的性質 ,  活性