文献

J-GLOBAL ID：201702211009367586   整理番号：17A0655931

CDCP1-PKCδ経路を抑制する新規低分子は腫瘍の転移と増殖を減じる

Novel small molecule inhibiting CDCP1-PKCδ pathway reduces tumor metastasis and proliferation

著者 (13件)： Nakashima Katsuhiko (Division of Refractory and Advanced Cancer, National Cancer Center Research Institute, Tokyo, Japan) ,  Uekita Takamasa (Department of Applied Chemistry, National Defense Academy, Yokosuka, Japan) ,  Yano Shigenobu (Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan) ,  Kikuchi Jun-ichi (Graduate School of Materials Science, Nara Institute of Science and Technology, Nara, Japan) ,  Nakanishi Ruri (Division of Refractory and Advanced Cancer, National Cancer Center Research Institute, Tokyo, Japan) ,  Sakamoto Nozomi (Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan) ,  Fukumoto Keisuke (Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan) ,  Nomoto Akihiro (Department of Applied Chemistry, Graduate School of Engineering, Osaka Prefecture University, Osaka, Japan) ,  Kawamoto Keisuke (Department of Chemistry, Graduate School of Natural Science, Kanazawa University, Kanazawa, Japan) ,  Shibahara Takashi (Department of Chemistry, Okayama University of Science, Okayama, Japan) ,  Yamaguchi Hideki (Division of Refractory and Advanced Cancer, National Cancer Center Research Institute, Tokyo, Japan) ,  Sakai Ryuichi (Division of Refractory and Advanced Cancer, National Cancer Center Research Institute, Tokyo, Japan) ,  Sakai Ryuichi (Division of Biochemistry, Kitasato University School of Medicine, Kanagawa, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 108  号： 5  ページ： 1049-1057  発行年： 2017年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： CUBドメイン含有蛋白質1(CDCP1)は各癌細胞で優勢に発...

シソーラス用語： 抗腫瘍作用 ,...
準シソーラス用語： BALB/cマウス ,...

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著者キーワード (5件)： CDCP1 ,  chemical screening ,  metastasis ,  PKCδ ,  Src

分類 (3件)： 腫ようの実験的治療  (GE02040Y) ,  抗腫よう薬の基礎研究  (GW16010A) ,  消化器の腫よう  (GH04000D)

引用文献 (38件)：

• Scherl-Mostageer M, Sommergruber W, Abseher R, Hauptmann R, Ambros P, Schweifer N. Identification of a novel gene, CDCP1, overexpressed in human colorectal cancer. Oncogene 2001; 20: 4402-8.
• Uekita T, Jia L, Narisawa-Saito M, Yokota J, Kiyono T, Sakai R. CUB domain-containing protein 1 is a novel regulator of anoikis resistance in lung adenocarcinoma. Mol Cell Biol 2007; 27: 7649-60.
• Uekita T, Sakai R. Roles of CUB domain-containing protein 1 signaling in cancer invasion and metastasis. Cancer Sci 2011; 102: 1943-8.
• Benes CH, Wu N, Elia AE, Dharia T, Cantley LC, Soltoff SP. The C2 domain of PKCdelta is a phosphotyrosine binding domain. Cell 2005; 121: 271-80.
• Miyazawa Y, Uekita T, Ito Y, Seiki M, Yamaguchi H, Sakai R. CDCP1 regulates the function of MT1-MMP and invadopodia-mediated invasion of cancer cells. Mol Cancer Res 2013; 11: 628-37.

タイトルに関連する用語 (4件)： 経路 ,  低分子 ,  腫瘍 ,  増殖