文献

J-GLOBAL ID：201702274716200537   整理番号：17A0601488

プロテインキナーゼA阻害はバロシン含有蛋白質阻害剤であるキサントフモールの抗腫瘍活性を促進する

Protein kinase A inhibition facilitates the antitumor activity of xanthohumol, a valosin-containing protein inhibitor

著者 (13件)： Shikata Yuki (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Yoshimaru Tetsuro (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Komatsu Masato (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Katoh Hiroto (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Katoh Hiroto (JST, PRESTO, Saitama, Japan) ,  Sato Reiko (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Kanagaki Shuhei (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Okazaki Yasumasa (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan) ,  Toyokuni Shinya (Department of Pathology and Biological Responses, Nagoya University Graduate School of Medicine, Nagoya, Aichi, Japan) ,  Tashiro Etsu (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan) ,  Ishikawa Shumpei (Department of Genomic Pathology, Medical Research Institute, Tokyo Medical and Dental University, Tokyo, Japan) ,  Katagiri Toyomasa (Division of Genome Medicine, Institute for Genome Research, Tokushima University, Tokushima, Japan) ,  Imoto Masaya (Department of Biosciences and Informatics, Faculty of Science and Technology, Keio University, Yokohama, Japan)
資料名： Cancer Science (Web)  (Cancer Science (Web))
巻： 108  号： 4  ページ： 785-794  発行年： 2017年 
JST資料番号： U0505A  ISSN： 1349-7006  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 単純なプレニル化カルコンであるキサントフモール(XN)は,ホ...

シソーラス用語： *ホップ ,...
準シソーラス用語： 細胞情報伝達 ,...

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著者キーワード (5件)： Adenylate cyclase ,  antitumor activity ,  apoptosis ,  valosin-containing protein ,  xanthohumol

分類 (3件)： 腫ようの実験的治療  (GE02040Y) ,  抗腫よう薬の基礎研究  (GW16010A) ,  生薬の薬理の基礎研究  (GX06020J)

物質索引 (1件)： キサントフモール

引用文献 (34件)：

• Power FB, Tutin F, Rogerson H. CXXXV.-The constituents of hops. J Chem Soc Trans 1913; 103: 1267-92.
• Cho Y-C, Kim HJ, Kim Y-J, et al. Differential anti-inflammatory pathway by xanthohumol in IFN-γ and LPS-activated macrophages. Int Immunopharmacol 2008; 8: 567-73.
• Vogel S, Ohmayer S, Brunner G, Heilmann J. Natural and non-natural prenylated chalcones: synthesis, cytotoxicity and anti-oxidative activity. Bioorg Med Chem 2008; 16: 4286-93.
• Albini A, Dell'Eva R, Vené R, et al. Mechanisms of the antiangiogenic activity by the hop flavonoid xanthohumol: NF-κB and Akt as targets. FASEB J 2006; 20: 527-9.
• Bhattacharya S, Virani S, Zavro M, Haas GJ. Inhibition of streptococcus mutans and other oral streptococci by hop (Humulus lupulus L.) constituents. Econ Bot 2003; 57: 118-25.

タイトルに関連する用語 (7件)： プロテインキナーゼA ,  阻害 ,  バロシン含有蛋白質 ,  阻害剤 ,  キサントフモール ,  抗腫瘍活性 ,  促進