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J-GLOBAL ID：201802290930157517   整理番号：18A1114843

活性化T細胞における染色体接触は自己免疫疾患候補遺伝子を同定する【JST・京大機械翻訳】

Chromosome contacts in activated T cells identify autoimmune disease candidate genes

著者 (40件)： Burren Oliver S. (Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK) ,  Burren Oliver S. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Garcia Arcadio Rubio (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Garcia Arcadio Rubio (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Javierre Biola-Maria (Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK) ,  Rainbow Daniel B. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Rainbow Daniel B. (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Cairns Jonathan (Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK) ,  Cooper Nicholas J. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Lambourne John J. (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Schofield Ellen (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Dopico Xaquin Castro (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Ferreira Ricardo C. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Ferreira Ricardo C. (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Coulson Richard (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Burden Frances (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Burden Frances (National Health Service Blood and Transplant, Cambridge, UK) ,  Rowlston Sophia P. (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Rowlston Sophia P. (National Health Service Blood and Transplant, Cambridge, UK) ,  Downes Kate (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Downes Kate (National Health Service Blood and Transplant, Cambridge, UK) ,  Wingett Steven W. (Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK) ,  Frontini Mattia (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Frontini Mattia (National Health Service Blood and Transplant, Cambridge, UK) ,  Frontini Mattia (British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, UK) ,  Ouwehand Willem H. (Department of Haematology, University of Cambridge, Cambridge, UK) ,  Ouwehand Willem H. (National Health Service Blood and Transplant, Cambridge, UK) ,  Ouwehand Willem H. (British Heart Foundation Centre of Excellence, Division of Cardiovascular Medicine, Addenbrooke’s Hospital, Cambridge, UK) ,  Ouwehand Willem H. (Department of Human Genetics, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, UK) ,  Fraser Peter (Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK) ,  Spivakov Mikhail (Nuclear Dynamics Programme, The Babraham Institute, Cambridge, UK) ,  Todd John A. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Todd John A. (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Wicker Linda S. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Wicker Linda S. (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Cutler Antony J. (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Cutler Antony J. (Present address: JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Wellcome Trust Centre for Human Genetics, Nuffield Department of Medicine, NIHR Oxford Biomedical Research Centre, University of Oxford, Oxford, UK) ,  Wallace Chris (Department of Medicine, University of Cambridge, Addenbrooke’s Hospital, Cambridge, UK) ,  Wallace Chris (JDRF/Wellcome Trust Diabetes and Inflammation Laboratory, Department of Medical Genetics, NIHR Cambridge Biomedical Research Centre, Cambridge Institute for Medical Research, University of Cambridge, Cambridge, UK) ,  Wallace Chris (MRC Biostatistics Unit, University of Cambridge, Cambridge Institute of Public Health, Cambridge, UK)
資料名： Genome Biology (Web)  (Genome Biology (Web))
巻： 18  号： 1  ページ： 165  発行年： 2017年 
JST資料番号： U7384A  ISSN： 1474-760X  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： イギリス (GBR)  言語： 英語 (EN)

抄録/ポイント： 背景:自己免疫疾患関連変異体は,免疫細胞,特にCD4+T細胞の調節領域で優先的に見出される。疾患関連細胞状況における遺伝子プロモーターへのそのような調節領域の連結は候補疾患遺伝子の同定を容易にする。【結果】4時間後に,CD4+T細胞の活性化は,プロモーター捕捉Hi-Cによって同定された相互作用遺伝子の発現変化に対応するヒストン修飾およびエンハンサーRNA転写の変化を引き起こす。プロモーター捕捉Hi-Cデータを5つの自己免疫疾患に対する遺伝的関連と統合することにより,ピークシグナルから153kbの優先遺伝子までの中央距離を持つ245候補遺伝子を優先した。活性化感受性相互作用に関連する半(108/245)優先遺伝子の下にある。これはIL2RAを含み,対立遺伝子特異的発現分析はその相互作用仲介調節と一致し,このアプローチの有用性を示した。結論:著者らの系統的な実験的枠組みは,達成可能なサンプルサイズを有する細胞状態特異的機能的効果を有する変異体に対する候補原因遺伝子同定に対する代替アプローチを提供する。Copyright 2018 The Author(s). All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 遺伝学 ,  *自己免疫病 ,  プロモーター領域 ,  対立遺伝子 ,  *遺伝子 ,  *染色体 ,  感受性 ,  捕獲 ,  相互作用 ,  RNA【核酸】
準シソーラス用語： CD4陽性細胞 ,  ヒストン修飾 ,  CD4陽性T細胞 ,  免疫細胞 ,  *候補遺伝子 , 【Automatic Indexing@JST】

著者キーワード (7件)： 遺伝学 ,  ゲノミクス ,  クロマチンの立体配座 ,  CD4+T細胞 ,  CD4+T細胞活性化 ,  自己免疫疾患 ,  ゲノムワイド関連研究

分類 (1件)： 免疫反応一般  (ED03010T)

引用文献 (82件)：

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• Genome Res.; Unbiased analysis of potential targets of breast cancer susceptibility loci by Capture Hi-C; NH Dryden, LR Broome, F Dudbridge, N Johnson, N Orr, S Schoenfelder; 24; 2014; 1854-68; 10.1101/gr.175034.114; CR5;

タイトルに関連する用語 (5件)： 活性化T細胞 ,  染色体 ,  自己免疫疾患 ,  候補遺伝子 ,  同定