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J-GLOBAL ID：201902282384815008   整理番号：19A1564528

毛髪中の銅レベルと灰白質容積,平均拡散率および認知機能との関連【JST・京大機械翻訳】

Association of copper levels in the hair with gray matter volume, mean diffusivity, and cognitive functions

著者 (27件)： Takeuchi Hikaru (Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Taki Yasuyuki (Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Taki Yasuyuki (Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Taki Yasuyuki (Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Nouchi Rui (Creative Interdisciplinary Research Division, Frontier Research Institute for Interdisciplinary Science, Tohoku University, Sendai, Japan) ,  Nouchi Rui (Human and Social Response Research Division, International Research Institute of Disaster Science, Tohoku University, Sendai, Japan) ,  Nouchi Rui (Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Yokoyama Ryoichi (School of Medicine, Kobe University, Kobe, Japan) ,  Kotozaki Yuka (Division of Clinical research, Medical-Industry Translational Research Center, Fukushima Medical University School of Medicine, Fukushima, Japan) ,  Nakagawa Seishu (Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Nakagawa Seishu (Division of Psychiatry, Tohoku Medical and Pharmaceutical University, Sendai, Japan) ,  Sekiguchi Atsushi (Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan) ,  Sekiguchi Atsushi (Department of Behavioral Medicine, National Institute of Mental Health, National Center of Neurology and Psychiatry, Tokyo, Japan) ,  Iizuka Kunio (Department of Psychiatry, Tohoku University Graduate School of Medicine, Sendai, Japan) ,  Yamamoto Yuki (Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Hanawa Sugiko (Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Araki Tsuyoshi (ADVANTAGE Risk Management Co., Ltd, Tokyo, Japan) ,  Miyauchi Carlos Makoto (Department of Language Sciences, Graduate School of Humanities, Tokyo Metropolitan University, Tokyo, Japan) ,  Sakaki Kohei (Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Nozawa Takayuki (Collaborative Research Center for Happiness Co-Creation Society through Intelligent Communications, Tokyo Institute of Technology, Tokyo, Japan) ,  Ikeda Shigeyuki (Department of Ubiquitous Sensing, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Yokota Susumu (Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Daniele Magistro (Department of Sport Science, School of Science and Technology, Nottingham Trent University, Nottingham, UK) ,  Sassa Yuko (Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Kawashima Ryuta (Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Kawashima Ryuta (Department of Advanced Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan) ,  Kawashima Ryuta (Department of Human Brain Science, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan)
資料名： Brain Structure and Function  (Brain Structure and Function)
巻： 224  号： 3  ページ： 1203-1217  発行年： 2019年 
JST資料番号： W4119A  ISSN： 1863-2653  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： ドイツ (DEU)  言語： 英語 (EN)

抄録/ポイント： 銅は正常な脳機能と発生において重要な役割を果たすが,過剰の銅は毒性を引き起こすことが知られている。ここでは,924人の健康な若年成人の研究コホートにおいて,毛髪における銅レベルと地域灰白質量(rGMV),平均拡散率(MD)および認知差との関連を検討した。著者らの知見は,高い銅レベルが,脳組織における低密度を示す右黒質および両側海馬の高MDと同様に,脳の広範な領域にわたる高rGMVと同様に,低い認知能力(複雑な速度タスクから構成される知能試験の低いスコア)に関連していることを示した。これらの結果は,銅レベルが大部分の異常な認知機能,広範な領域におけるより大きなrGMV,より大きなMD(脳組織における低密度を示す)と関連していることを示唆しており,神経機構における銅の複雑な役割を反映している可能性がある。Copyright 2019 Springer-Verlag GmbH Germany, part of Springer Nature Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： *灰白質 ,  *銅 ,  知能検査 ,  毒性 ,  母集団 ,  海馬
準シソーラス用語： 神経機構 ,  スコア ,  認知能力 ,  低密度 ,  脳組織 ,  若年成人 ,  健康 ,  脳機能 ,  *認知機能 , 【Automatic Indexing@JST】

著者キーワード (4件)： 銅 ,  地域灰白質容積 ,  平均拡散率 ,  認知機能

分類 (1件)： 中枢神経系  (EJ12030F)

タイトルに関連する用語 (6件)： 毛髪 ,  銅 ,  灰白質 ,  容積 ,  平均拡散率 ,  認知機能