文献

J-GLOBAL ID：202002286330500826   整理番号：20A1919316

細胞外小胞と粒子バイオマーカーは複数のヒト癌を規定する【JST・京大機械翻訳】

Extracellular Vesicle and Particle Biomarkers Define Multiple Human Cancers

著者 (120件)： Hoshino Ayuko (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hoshino Ayuko (School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan) ,  Hoshino Ayuko (Japan Science and Technology Agency, PRESTO, Tokyo, Japan) ,  Kim Han Sang (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Kim Han Sang (Yonsei Cancer Center, Division of Medical Oncology, Department of Internal Medicine, Brain Korea 21 Plus Project for Medical Sciences, Severance Biomedical Science Institute, Yonsei University College of Medicine, Seoul, Korea) ,  Bojmar Linda (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Bojmar Linda (Department of Biomedical and Clinical Sciences, Linkoping University, Linkoping, Sweden) ,  Bojmar Linda (Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden) ,  Gyan Kofi Ennu (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Gyan Kofi Ennu (Tri-Institutional PhD Program in Computational Biology and Medicine, New York, NY, USA) ,  Cioffi Michele (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hernandez Jonathan (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hernandez Jonathan (Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Hernandez Jonathan (Surgical Oncology Program, National Cancer Institute, National Institutes of Health, Bethesda, MD USA) ,  Zambirinis Constantinos P. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Zambirinis Constantinos P. (Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Rodrigues Goncalo (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Rodrigues Goncalo (Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal) ,  Molina Henrik (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Heissel Soren (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Mark Milica Tesic (Proteomics Resource Center, The Rockefeller University, New York, NY, USA) ,  Steiner Loiec (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Steiner Loiec (Swiss Institute for Experimental Cancer Research, School of Life Sciences, Ecole Polytechnique Federale de Lausanne, Lausanne, Switzerland) ,  Benito-Martin Alberto (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Lucotti Serena (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Di Giannatale Angela (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Di Giannatale Angela (Department of Pediatric Haematology/Oncology, IRCCS Bambino Gesu Children’s Hospital, Rome, Italy) ,  Offer Katharine (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Nakajima Miho (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Williams Caitlin (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Nogues Laura (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Nogues Laura (Microenvironment and Metastasis Laboratory, Department of Molecular Oncology, Spanish National Cancer Research Center (CNIO), Madrid, Spain) ,  Pelissier Vatter Fanny A. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hashimoto Ayako (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Hashimoto Ayako (School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan) ,  Hashimoto Ayako (Department of Obstetrics and Gynecology, Faculty of Medicine, University of Tokyo, Tokyo, Japan) ,  Davies Alexander E. (Department of Veterinary Biosciences, College of Veterinary Medicine, The Ohio State University, Columbus, OH, USA) ,  Freitas Daniela (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Freitas Daniela (i3S-Institute for Research and Innovation in Health, University of Porto, Rua Alfredo Allen 208, Porto, Portugal) ,  Kenific Candia M. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Ararso Yonathan (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Buehring Weston (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Lauritzen Pernille (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Ogitani Yusuke (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Sugiura Kei (School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan) ,  Sugiura Kei (Graduate School of Pharmaceutical Sciences, The University of Tokyo, Tokyo, Japan) ,  Takahashi Naoko (School of Life Science and Technology, Tokyo Institute of Technology, Yokohama, Japan) ,  Aleckovic Masa (Department of Molecular Biology, Princeton University, Princeton, NJ, USA) ,  Bailey Kayleen A. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Jolissant Joshua S. (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Jolissant Joshua S. (Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Wang Huajuan (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Harris Ashton (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Schaeffer L. Miles (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Garcia-Santos Guillermo (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Garcia-Santos Guillermo (Department of General and Gastrointestinal Surgery, Hospital Universitario Central de Asturias (HUCA), Oviedo, Spain) ,  Posner Zoe (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  Balachandran Vinod P. (Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Balachandran Vinod P. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Khakoo Yasmin (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Raju G. Praveen (Department of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA) ,  Scherz Avigdor (Department of Plant and Environmental Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Sagi Irit (Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel) ,  Scherz-Shouval Ruth (Department of Biomolecular Sciences, Weizmann Institute of Science, Rehovot, Israel) ,  Yarden Yosef (Department of Biological Regulation, Weizmann Institute of Science, Rehovot, Israel) ,  Oren Moshe (Department of Molecular Cell Biology, Weizmann Institute of Science, Rehovot, Israel) ,  Malladi Mahathi (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Petriccione Mary (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  De Braganca Kevin C. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Donzelli Maria (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Fischer Cheryl (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Vitolano Stephanie (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Wright Geraldine P. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Ganshaw Lee (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Marrano Mariel (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Ahmed Amina (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  DeStefano Joe (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Danzer Enrico (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Danzer Enrico (Pediatric Surgical Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Roehrl Michael H.A. (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Roehrl Michael H.A. (Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Lacayo Norman J. (Lucile Packard Children’s Hospital Stanford, Stanford, CA, USA) ,  Vincent Theresa C. (Department of Immunology, Genetics and Pathology, Uppsala University, Rudbeck Laboratory, Uppsala, Sweden) ,  Vincent Theresa C. (Department of Microbiology, New York University School of Medicine, New York, NY, USA) ,  Weiser Martin R. (Colorectal Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Brady Mary S. (Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Meyers Paul A. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Wexler Leonard H. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Ambati Srikanth R. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Chou Alexander J. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Slotkin Emily K. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Modak Shakeel (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Roberts Stephen S. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Basu Ellen M. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Diolaiti Daniel (Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA) ,  Krantz Benjamin A. (Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA) ,  Krantz Benjamin A. (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Cardoso Fatima (Breast Unit, Champalimaud Clinical Center/Champalimaud Foundation, Lisbon, Portugal) ,  Simpson Amber L. (Hepatopancreatobiliary Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Berger Michael (Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Berger Michael (Department of Pathology, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Rudin Charles M. (Department of Medicine, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Simeone Diane M. (Perlmutter Cancer Center, New York University Langone Health, New York, NY, USA) ,  Jain Maneesh (Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA) ,  Ghajar Cyrus M. (Public Health Sciences Division/Translational Research Program, Fred Hutchinson Cancer Research Center, Seattle, WA, USA) ,  Batra Surinder K. (Fred and Pamela Buffett Cancer Center, University of Nebraska Medical Center, Omaha, NE, USA) ,  Stanger Ben Z. (Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA) ,  Bui Jack (Department of Pathology, University of California San Diego, La Jolla, CA, USA) ,  Brown Kristy A. (Department of Medicine, Weill Cornell Medicine, New York, NY, USA) ,  Rajasekhar Vinagolu K. (Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Healey John H. (Orthopedic Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  de Sousa Maria (Children’s Cancer and Blood Foundation Laboratories, Departments of Pediatrics, and Cell and Developmental Biology, Drukier Institute for Children’s Health, Meyer Cancer Center, Weill Cornell Medicine, New York, NY, USA) ,  de Sousa Maria (Graduate Program in Areas of Basic and Applied Biology, Abel Salazar Biomedical Sciences Institute, University of Porto, Porto, Portugal) ,  Kramer Kim (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA) ,  Sheth Sujit (Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA) ,  Baisch Jeanine (Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA) ,  Baisch Jeanine (Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY, USA) ,  Pascual Virginia (Department of Pediatrics, Weill Cornell Medicine, New York, NY, USA) ,  Pascual Virginia (Drukier Institute for Children’s Health, Weill Cornell Medicine, New York, NY, USA) ,  Heaton Todd E. (Department of Pediatrics, Memorial Sloan Kettering Cancer Center, New York, NY, USA)
資料名： Cell (Cambridge, Mass.)  (Cell (Cambridge, Mass.))
巻： 182  号： 4  ページ： 1044-1061.e18  発行年： 2020年 
JST資料番号： A0707B  ISSN： 0092-8674  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： アメリカ合衆国 (USA)  言語： 英語 (EN)

抄録/ポイント： 癌検出のための組織および液体生検ツールの改善には,臨床的必要性がない。組織外植体(TEs),血漿,および他の体液からの426人のヒト試料中の細胞外小胞と粒子(EVP)のプロテオームプロファイルを調べた。従来のエキソソームマーカーの中で,CD9,HSPA8,ALIX,およびHSP90AB1は汎EVPマーカーであり,一方,ACTB,MSN,およびRAP1Bは新規汎EVPマーカーである。EVPが理想的な診断ツールであることを確認するため,TE-(n=151)と血漿由来(n=120)EVPのプロテオームを分析した。TE EVPsの比較は,90%の感度/94%の特異性で正常組織から腫瘍を区別する蛋白質(例えば,VCAN,TNC,およびTHBS2)を同定した。免疫グロブリンを含む血漿由来EVPカーゴの機械学習分類は,癌の検出において95%の感度/90%の特異性を明らかにした。最後に,TEと血漿中の腫瘍型特異的EVP蛋白質のパネルを定義し,未知の原発起源の腫瘍を分類できた。したがって,EVP蛋白質は癌検出と癌タイプ決定のための信頼できるバイオマーカーとして役立つ。Copyright 2020 Elsevier B.V., Amsterdam. All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 血漿 ,  免疫グロブリン ,  腫瘍 ,  体液 ,  タンパク質 ,  ヒト ,  貨物 ,  *バイオマーカー ,  機械学習 ,  プロテオーム
準シソーラス用語： エキソソーム ,  CD9抗原 ,  がん検出 ,  *細胞外小胞 ,  リキッドバイオプシー , 【Automatic Indexing@JST】

著者キーワード (10件)： エキソソーム ,  エクソメア ,  細胞外小胞と粒子 ,  プロテオミクス ,  癌 ,  液体生検 ,  バイオマーカー ,  早期癌検出 ,  原発不明の癌 ,  損傷関連分子パターン

分類 (2件)： 生物学的機能  (EB03040U) ,  細胞生理一般  (EF02010S)

タイトルに関連する用語 (5件)： 細胞外小胞 ,  バイオマーカー ,  ヒト ,  癌 ,  規定