文献

J-GLOBAL ID：202102220479251973   整理番号：21A1336064

イミダクロプリドへの慢性低用量曝露はC57BL/6J雄マウスにおける高脂肪食媒介肝脂肪変性を高める

Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

著者 (12件)： NIMAKO Collins (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  IKENAKA Yoshinori (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  IKENAKA Yoshinori (Water Research Group, Unit for Environmental Sciences and Management, North-West University, 11 Hoffman Street, Potchefstroom 2531, South Africa) ,  OKAMATSU-OGURA Yuko (Laboratory of Biochemistry, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  BARIUAN Jussiaea V. (Laboratory of Biochemistry, Department of Basic Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  KOBAYASHI Atsushi (Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  YAMAZAKI Ryo (Laboratory of Comparative Pathology, Department of Clinical Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  TAIRA Kumiko (Department of Anesthesiology, Tokyo Women’s Medical University Center East, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan) ,  HOSHI Nobuhiko (Department of Animal Science, Graduate School of Agricultural Science, Kobe University, 1-1 Rokkodai, Nada-ku, Kobe, Hyogo 657-8501, Japan) ,  HIRANO Tetsushi (Division of Drug and Structure Research, Life Science Research Center, University of Toyama, Sugitani 2630, Toyama 930-0194, Japan) ,  NAKAYAMA Shouta M. M. (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan) ,  ISHIZUKA Mayumi (Laboratory of Toxicology, Department of Environmental Veterinary Sciences, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo, Hokkaido 060-0818, Japan)
資料名： Journal of Veterinary Medical Science (Web)  (Journal of Veterinary Medical Science (Web))
巻： 83  号： 3  ページ： 487-500(J-STAGE)  発行年： 2021年 
JST資料番号： U1094A  ISSN： 1347-7439  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： 日本 (JPN)  言語： 英語 (EN)

抄録/ポイント： 脂肪肝は肝代謝機能不全,炎症および発癌に至る連続的病態に先行...

シソーラス用語： *脂肪肝 ,...
準シソーラス用語： サイトゾル受容体 ,...

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著者キーワード (4件)： ネオニコチノイド殺虫剤 ,  イミダクロプリド ,  脂肪肝 ,  観測可能な副作用レベル(NOAEL)

分類 (4件)： 代謝異常・栄養性疾患一般  (GD05010J) ,  消化器の基礎医学  (GH01020E) ,  脂質の代謝と栄養  (EJ02034Q) ,  肝臓  (EJ06060J)

物質索引 (1件)： イミダクロプリド

引用文献 (47件)：

• 1. Alves-Bezerra, M. and Cohen, D. E. 2017. Triglyceride metabolism in the liver. Compr. Physiol. 8: 1-8.
• 2. Buechler, C. and Bauer, S. 2011. IL-6 in non-alcoholic fatty liver disease -good, evil or both? Endocrinol. Metab. Syndr. 1: e101.
• 3. Chaves, V. E., Frasson, D. and Kawashita, N. H. 2011. Several agents and pathways regulate lipolysis in adipocytes. Biochimie 93: 1631-1640.
• 4. Chen, M., Tao, L., McLean, J. and Lu, C. 2014. Quantitative analysis of neonicotinoid insecticide residues in foods: implication for dietary exposures. J. Agric. Food Chem. 62: 6082-6090.
• 5. Clemens, M. G. 1999. Nitric oxide in liver injury. Hepatology 30: 1-5.

タイトルに関連する用語 (7件)： イミダクロプリド ,  慢性 ,  低用量 ,  曝露 ,  マウス ,  高脂肪食 ,  肝脂肪変性