文献

J-GLOBAL ID：202102294755311690   整理番号：21A0196273

重症COVID-19急性呼吸窮迫症候群における補体阻害【JST・京大機械翻訳】

Complement Inhibition in Severe COVID-19 Acute Respiratory Distress Syndrome

著者 (17件)： Raghunandan Sharmila (Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States) ,  Raghunandan Sharmila (Aflac Cancer and Blood Disorders Center, Atlanta, GA, United States) ,  Josephson Cassandra D. (Aflac Cancer and Blood Disorders Center, Atlanta, GA, United States) ,  Josephson Cassandra D. (Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States) ,  Verkerke Hans (Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States) ,  Linam W. Matthew (Division of Pediatric Infectious Diseases, Emory University School of Medicine and Children’s Healthcare of Atlanta, Atlanta, GA, United States) ,  Ingram Treva C. (Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States) ,  Ingram Treva C. (Division of Pediatric Intensive Care Unit, Children’s Healthcare of Atlanta, Atlanta, GA, United States) ,  Zerra Patricia E. (Aflac Cancer and Blood Disorders Center, Atlanta, GA, United States) ,  Zerra Patricia E. (Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States) ,  Arthur Connie M. (Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States) ,  Stowell Sean R. (Center for Transfusion and Cellular Therapy, Department of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA, United States) ,  Stowell Sean R. (Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School, Boston, MA, United States) ,  Briones Michael (Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States) ,  Briones Michael (Aflac Cancer and Blood Disorders Center, Atlanta, GA, United States) ,  Chonat Satheesh (Department of Pediatrics, Emory University School of Medicine, Atlanta, GA, United States) ,  Chonat Satheesh (Aflac Cancer and Blood Disorders Center, Atlanta, GA, United States)
資料名： Frontiers in Pediatrics (Web)  (Frontiers in Pediatrics (Web))
巻： 8  ページ： 616731  発行年： 2020年 
JST資料番号： U7090A  ISSN： 2296-2360  資料種別： 逐次刊行物 (A)
記事区分： 原著論文  発行国： スイス (CHE)  言語： 英語 (EN)

抄録/ポイント： COVID-19のほとんどの子供は,無症候性または軽度の疾患を有する。急性呼吸 distress迫症候群(ARDS)と急性腎障害(AKI)が重症になる。肺機能の急速な悪化は,COVID-19の成人患者の肺に見られる微小血管変性および免疫介在過程にリンクしている。補体媒介急性肺損傷の役割は,SARS-CoVの動物モデル,COVID-19から死亡した患者の肺組織の評価,および補体阻害に対するCOVID-19ARDSの応答によって支持された。回復血漿とエクリズマブで治療したCOVID-19疾患の子供の要約を提示し,炎症経路の詳細な評価を提供する。Copyright 2021 The Author(s) All rights reserved. Translated from English into Japanese by JST.【JST・京大機械翻訳】

シソーラス用語： 血漿 ,  *補体 ,  炎症 ,  成人 ,  子供
準シソーラス用語： 重症急性呼吸器症候群 ,  動物モデル ,  肺機能 ,  急性肺損傷 ,  エクリズマブ ,  急性腎障害 ,  肺組織 ,  微小血管 , 【Automatic Indexing@JST】

著者キーワード (7件)： 補体 ,  COVID-19 ,  SARS-CoV-2 ,  エクリズマブ ,  急性呼吸窮迫症候群(ARDS) ,  小児 ,  小児

分類 (4件)： 呼吸器の疾患  (GI03000Z) ,  ウイルス感染の生理と病原性  (EG04042Y) ,  感染症・寄生虫症一般  (GD01010H) ,  呼吸器疾患の治療一般  (GI05010Y)

引用文献 (20件)：

• LudvigssonJF. Systematic review of COVID-19 in children shows milder cases and a better prognosis than adults. Acta Paediatr. (2020) 109:1088-95. doi: 10.1111/apa1527032202343
• JiangLTangKLevinMIrfanOMorrisSKWilsonK. COVID-19 and multisystem inflammatory syndrome in children and adolescents. Lancet Infect Dis. (2020) 20:e276-88. doi: 10.1016/S1473-3099(20)30651-432818434
• JosephAZafraniLMabroukiAAzoulayEDarmonM. Acute kidney injury in patients with SARS-CoV-2 infection. Ann Intensive Care. (2020) 10:117. doi: 10.1186/s13613-020-00734-z32880774
• BorczukACSalvatoreSPSeshanSVPatelSSBusselJBMostykaM. COVID-19 pulmonary pathology: a multi-institutional autopsy cohort from Italy and New York City. Mod Pathol. (2020) 33:2156-68. doi: 10.1038/s41379-020-00661-132879413
• NorisMBenigniARemuzziG. The case of complement activation in COVID-19 multiorgan impact. Kidney Int. (2020) 98:314-22. doi: 10.1016/j.kint.20200501332461141

タイトルに関連する用語 (4件)： 重症 ,  急性呼吸窮迫症候群 ,  補体 ,  阻害