Research field (4)：
Pharmaceuticals - chemistry and drug development
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Applied biofunctional and bioprocess engineering
Research theme for competitive and other funds (42)：
2016 - 2020 Development of artificial antibody of anti-bitter taste receptor using random amino acid sequence library
2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy
2016 - 2018 Development of animal models for anti-neurofascin 155 antibody-positive inflammatory demyelinating diseases by single chain antibodies
2014 - 2017 Research on the treatment of esophageal cancer with anti-human fibroblast growth factor receptor like-1
2013 - 2016 Immunotherapy for ATL using specific chimeric antigen receptor
2013 - 2016 Development of anti-cancer antibodies through high-throughput sequencing from antibody phage library
2013 - 2015 Anti-ghrelin immunoglobulins modulate ghrelin stability and its orexigenic effect in obese mice and humans.
2012 - 2015 Ghrelin and ghrelin autoabs in anorexia nervosa.
2011 - 2014 Development of single chain antibodies against sugar chain tumor antigen on the surface of leukemia cells and their application for order-made medicine
2011 - 2012 A study of TCR-V・targeted antibody therapy against human T cell lymphoma
2009 - 2011 Construction of human antibody library and establishment of selection method to develop fragment antibody therapeutics
2009 - 2011 Amyloid beta-42-mimotope displaying M13 bacteriophage for vaccine vehicle of Alzheimer's disease
2007 - 2009 環状ジ置換アミノ酸配座固定ペプチドライブラリーによる免疫制御分子の探索
2007 - 2009 Studies of antibody therapy for treatment of adult T-cell leukemia targeting surface carbohydrate molecules
2006 - 2008 A new therapeutic concept for the treatment against sepsis using a functional material, 1,5-anhydrofructose
2006 - 2007 Basic studies for development of inhibitor to target nuclear inflammatory cytokine related with sepsis
2007 - 制御型ヒト抗体結合ペプチドによる抗体の検出、精製技術の開発
2004 - 2005 Prion-conformation-specific human antibodies established from phage display library.
2004 - 2005 Fundamental researches for antibody medicine development by the virus vector aiming at control of the immune response
2005 - HTLV-1関連疾患に対する発症予防と治療法確立に関する研究
2005 - 医薬品応用を目指したファージディスプレイによる生理活性ペプチドのデザイン
2005 - Bioactive design by random peptide phage library for medicinal application
2001 - 2003 Isolation of human antibodies targeting to immunocytes from phage library and regulation of immune response
2002 - 抗体医薬開発を目指したファージ抗体ライブラリによるヒト抗体のデザイン
2002 - Design of therapeutic human antibody by phage display system for medicinal application
2001 - 2001 ファージディスプレイライブラリーを用いた感染防御と免疫制御法の開発
2001 - 2001 エイズ感染阻子分子の分子設計法の基礎研究
1999 - 2001 Molecular design of functional domain-mimics of receptors and ligands
2000 - 2000 免疫制御分子の機能性ドメインミミックの分子設計と免疫制御
2000 - 2000 エイズ感染阻止分子の分子設計法の基礎研究
2000 - 2000 免疫細胞への標的機能を持つバイオコンジュゲートによる免疫制御
1999 - 2000 免疫細胞標的モチーフによる抗原特異的免疫増強とワクチン開発への応用
1999 - 1999 エイズワクチンの活性強化分子の分子設計法の基礎研究
1999 - 1999 免疫細胞への標的機能を持つバイオコンジュゲートによる免疫制御
1998 - 1998 エイズワクチンの活性強化分子の分子設計法の基礎研究
1998 - 1998 免疫細胞への標的機能を持つバイオコンジュゲートによる免疫制御
1997 - 1998 複合糖質の合成を目指した蛋白工学による加水分解酵素の反応特異性の改変
1996 - 1996 ランダム変異を用いたリゾチームのフォルディング情報の解析
1995 - 1995 ランダム変異を用いたリゾチームのフォルディング情報の解析
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Papers (98)：
Kyohei Muguruma, Akane Fukuda, Hayate Shida, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi. Structure Derivatization of IgG-Binding Peptides and Analysis of Their Secondary Structure by Circular Dichroism Spectroscopy. Chemical & pharmaceutical bulletin. 2024. 72. 9. 831-837
Abdur Rafique, Genki Hichiwa, Muhammad Feisal Jatnika, Yuji Ito. A Novel Strategy for Screening Tumor-Specific Variable Domain of Heavy-Chain Antibodies. International Journal of Molecular Sciences. 2023. 24. 13. 10804-10804
Tomonari Matsuda, Yoko Akazawa-Ogawa, Lilian-Kaede Komaba, Norihiko Kiyose, Nobuo Miyazaki, Yusaku Mizuguchi, Tetsuo Fukuta, Yuji Ito, Yoshihisa Hagihara. Prediction of antigen-responding VHH antibodies by tracking the evolution of antibody along the time course of immunization. Frontiers in immunology. 2023. 14. 1335462-1335462
Narutoshi Tsukahara, Akikazu Murakami, Maiko Motohashi, Hiroshi Nakayama, Yoshiro Kondo, Yuji Ito, Takachika Azuma, Hidehiro Kishimoto. An alpaca single-domain antibody (VHH) phage-display library constructed by CDR shuffling provided high affinity VHHs against desired protein antigens. International immunology. 2022
Kyohei Muguruma, Rento Osawa, Akane Fukuda, Naoto Ishikawa, Konomi Fujita, Akihiro Taguchi, Kentaro Takayama, Atsuhiko Taniguchi, Yuji Ito, Yoshio Hayashi. Development of a High-Affinity Antibody-Binding Peptide for Site-Specific Modification. ChemMedChem. 2021. 16. 11. 1813-1820
赤澤陽子, 松田知成, 宮崎誠生, 清瀬紀彦, 伊東祐二, 萩原義久. The predictions of high affinity single domain VHH antibody through repeated immunizations. 日本蛋白質科学会年会プログラム・要旨集. 2022. 22nd (Web)
