Rchr
J-GLOBAL ID：200901019095970134
Update date: Dec. 19, 2024
Murata Hitoshi
ムラタ ヒトシ | Murata Hitoshi
Affiliation and department：
Job title：
Senior Assistant Professor
Homepage URL (2)：
https://www.okayama-u.ac.jp/user/cellbiol/
,
https://pxy-www.a.okayama-u.ac.jp/user/cellbiol/
Research field (2)：
Functional biochemistry
, Molecular biology
Research keywords (11)：
Neurodegenerative disease
, Parkinson's disease
, ミトコンドリア
, SARM1
, NAD
, PINK1
, 細胞生物学
, タンパク質工学
, Mitochondria
, Cell Biology
, Protein Engneering
Research theme for competitive and other funds (13)：
- 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- 2023 - 2026 S100A8/A9-向転移とHRG-抗転移の細胞間・分子間クロストークの解明
- 2022 - 2025 軸索変性誘導分子SARM1の活性・分解制御によるパーキンソン病治療法の開発
- 2020 - 2023 新規S100A8/A9阻害分子の発見に基づいたがん脳指向転移の機構解明とその制御
- 2019 - 2022 ミトコンドリア呼吸阻害による軸索変性誘導機構の解明とパーキンソン病への展開
- 2017 - 2020 Mechanistic analysis of an unidentified downstream signals of S100A8/A9 receptors that play a crucial role in acquisition of metastatic force and formation of cancer microenvironment.
- 2016 - 2019 ミトコンドリア呼吸制御機構の解析と神経変性疾患におけるその破綻
- 2015 - 2017 exSSSRs-Fc fusion decoys prevent S100A8/A9-mediated cancer metastasis.
- 2014 - 2017 Critical role of newly identified S100A8/A9 receptors in lung specific cancer metastasis
- 2013 - 2016 PINK1キナーゼを中心としたミトコンドリア恒常性維持機構の解析
- 2012 - 2015 Application of REIC/Dkk-3 gene therapy on gastrointestinal cancers targeting cancer stem cells
- 2011 - 2012 Establishment of protocol for building up monoclonal antibodies targeting cancer stem cells
- 2011 - 2012 Innovative improvement of cancer therapeutic adenovirus vector carrying REIC gene
Show all
Papers (65)：
-
Masakiyo Sakaguchi, Rie Kinoshita, Nahoko Tomonobu, Yoshihiko Sakaguchi, Junichiro Futami, Akira Yamauchi, Hitoshi Murata, Ken-Ichi Yamamoto, Tetta Takahashi, Yuma Gohara, et al. Enhanced design of pCMViR-TSC plasmid vector for sustainably high cargo gene expression in mammalian cells. In vitro cellular & developmental biology. Animal. 2024
-
Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. Correction: S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
-
Jin Zhou, Hitoshi Murata, Nahoko Tomonobu, Naoko Mizuta, Atsuko Yamakawa, Ken-Ichi Yamamoto, Rie Kinoshita, Masakiyo Sakaguchi. S100A11 is involved in the progression of colorectal cancer through the desmosome-catenin-TCF signaling pathway. In vitro cellular & developmental biology. Animal. 2024
-
Fan Jiang, Youyi Chen, Nahoko Tomonobu, Rie Kinoshita, Ni Luh Gede, Yoni Komalasari, Carlos Ichiro, Kasano-Camones, Kazumi Ninomiya, Hitoshi Murata, et al. Dissection of the signal transduction machinery responsible for the lysyl oxidase-like 4-mediated increase in invasive motility in triple-negative breast cancer cells: mechanistic insight into the integrin-β1-NF-κB-MMP9 axis. Front. Oncol. Sec. Molecular and Cellular Oncology. 2024. 14. 1371307
-
Tetta Takahashi, Nahoko Tomonobu, Rie Kinoshita, Ken-ichi Yamamoto, Hitoshi Murata, Ni Luh Gede Yoni Komalasari, Youyi Chen, Fan Jiang, Yuma Gohara, Toshiki Ochi, et al. Lysyl oxidase-like 4 promotes the invasiveness of triple-negative breast cancer cells by orchestrating the invasive machinery formed by annexin A2 and S100A11 on the cell surface. Frontiers in Oncology. 2024. 14
ｍore...
MISC (41)：
-
合原勇馬, 友信奈保子, 木下理恵, 山本建一, 村田等, 阪口政清. Nuclear PD-L1 facilitates disseminative activity by suppressing Protein X in triple-negative breast cancer cells. 日本癌学会学術総会抄録集(Web). 2023. 82nd
-
合原勇馬, 友信奈保子, 木下理恵, 村田等, 山本健一, 難波正義, 許南浩, 公文裕己, 阪口政清. A novel function of REIC protein on tumor suppression through the downregulation of PD-L1 on cancer cells. 組織培養研究(Web). 2023. 41. 2
-
山本健一, 平林大輔, 丸山顕嘉, 友信奈保子, 木下理恵, KOMALASARI Ni Luh Gade Yoni, 村田等, 合原勇馬, 江帆, 山内明, et al. The Zn2+-bound form of ZEB1 plays a crucial part in the promotion of invasiveness in breast cancer cells. 組織培養研究(Web). 2023. 41. 2
-
友信奈保子, 木下理恵, 合原勇馬, KOMALASARI Ni Luh Gede Yoni, JIANG Fan, 村田等, 山本健一, 山内明, 近藤英作, 豊岡伸一, et al. HRG suppresses the S100A8/A9-mediated metastasis of melanoma cells. 組織培養研究(Web). 2023. 41. 2
-
高橋徹多, 友信奈保子, KOMALASARI Ni Luh Gede Yoni, 合原勇馬, 山本健一, 木下理恵, 村田等, 阪口政清. Discovery of the mechanism of breast cancer progression focusing on cell-surface annexin A2/S100A11 binding. 組織培養研究(Web). 2023. 41. 2
ｍore...
Patents (6)：
Lectures and oral presentations (80)：
-
脳と腸の関係
(国際保健技療学会セミナー 2024)
-
NAD+消費酵素SARM1を介した神経変性メカニズムの解明から創薬を目指して
(和歌山県立医科大学セミナー 2024)
-
NAD+消費酵素SARM1を介した神経変性メカニズムの解明と創薬への応用
(東京理科大学パラレル脳勉強会・セミナー 2023)
-
REIC/Dkk-3の受容体への結合はトリプルネガティブ乳がんのPD-L1の発現を抑制する
(第45回 日本分子生物学会年会 2022)
-
神経軸索変性メカニズムの解明と創薬への応用
(第37回 創薬・薬理フォーラム岡山 2022)
ｍore...
Education (3)：
- - 2008 Okayama University The Graduate School of Natural Science and Technology (Doctor Course) Division of Chemistry and Biochemistry
- - 2005 Okayama University The Graduate School of Natural Science and Technology
- - 2003 Okayama University Faculty of Engineering Department of Bioscience and Biotechnology
Professional career (2)：
- 工学(博士) (岡山大学)
- 工学(修士) (岡山大学)
Work history (3)：
- 2016 - 現在 岡山大学 大学院医歯薬学総合研究科 講師
- 2010 - 2016 岡山大学 大学院医歯薬学総合研究科 助教
- 2008 - 2010 岡山大学 大学院医歯薬学総合研究科 特任助教
Awards (6)：
Association Membership(s) (4)：
THE JAPANESE TISSUE CULTURE ASSOCIATION
, THE JAPANESE BIOCHEMICAL SOCIETY
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPAN NEUROSCIENCE SOCIETY
