Kiyohara Hiroaki

キヨハラヒロアキ | Kiyohara Hiroaki

Affiliation and department：
Homepage URL (1)： http://www.kitasato-u.ac.jp

Research field (1)： Immunology

Research keywords (10)： Stromal cells , Peyer's patches , inulooligosaccharides , Oligosaccharides , Pectic polysaccharides , Polysaccharides , Hochuekkito , kampo medicine , Intestinal immunology , Mucosal immunology

Research theme for competitive and other funds (30)：

2021 - 2024 補中益気湯の免疫チェックポイント阻害剤による自己免疫性副作用発現の予防効果の解析
2020 - 2023 Mechanism of host-mediated anti-influenza virus activity of a Kampo medicine and its active ingredients
1990 - 2022 植物素材中の新薬理活性物質に関する研究
1990 - 2022 薬理活性ペクチン様多糖の活性発現糖鎖に関する研究
1990 - 2022 Study of new pharmacologically active substances in plant origin

1990 - 2022 Study of oligosaccharide sequences in pharmacologically active pectic polysaccharides for expression of activity

1982 - 2022 漢方薬中の多糖成分の役割に関する研究

1982 - 2022 Study for clarification of role of polysaccharides for Japanese herbal medicines

2018 - 2021 Suitable combination of crude drugs in Hochuekkito for immune control and anti-inflammatory of the gastrointestinal tract

2015 - 2018 Elucidation of immunoabnormality on plumonary mucosal immune system of streptozotocin-induced type I diabetes mice model and analysis of improving effect of Hachimigan

2014 - 2017 Host-mediated anti-influenza virus activity and action mechanism of a Kampo (traditional Japanese herbal) medicine "shakakusan"

2011 - 2013 Action mechanism of Ephedra Herb drug group against influenza virus infection

2011 - 2013 Elicidation of action mechanism of Hochuekkito through immunomodulation of intestinal epithelial cells

2009 - 2011 Study on clarification of action mechanism of a Kampo medicine, Hochuekkito through immunomodulating exosome

2008 - 2010 ACTION MECHANISM OF A KAMPO MEDICINE "MAOTO" AGAINST INFLUENZA VIRUS INFECTION

2006 - 2008 Basic research on mucosal immune system enhancing activity of Kampo medicines

2005 - 2007 ACTION MECHANISM OF A KAMPO MEDICINE "SHOSEIRYUTO" AGAINST AIRWAY INFECTION AND ITS ACTIVE SUBSTANCE

2004 - 2006 The comprehensive study on the modulation of airway mucosal immune system by hochuekkito

2002 - 2004 Clarification of oligosaccharides for modulation of common mucosal immune system by using formation of artificial oligosaccharide clusters

1999 - 2002 Research of the antimalarial drugs from the natural products

1996 - 1997 Studies on anti-dementia effects of Kampo medicines and their active ingredients

1994 - 1994 免疫調節漢方製剤「十全大補湯」の薬効発現における多糖成分の役割の解明

植物素材からの抗感染症薬の開発に関する研究

新規健康食品の開発及び有効性の評価に関する研究

和漢薬素材からの新規医薬品の開発に関する研究

機能性多糖の開発に関する研究

Research on Development of Novel Anti-ifection Agents from Plants

Research on development of novel functional foods and on evaluation of their efficacy

Research on development of novel pharmaceuticals from medicinal herbs

Research on development of therapeutic polysaccharides

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Papers (70)：

Takuya Maeda, Haruna Hosaka, Yuki Nakamura, Shuuji Mawaribuchi, Takayuki Nagai, Mari Endo, Naoki Ito, Hiroaki Kiyohara. Fibroblastic reticular cells and type 3 innate lymphoid cells in <scp>Peyer</scp> ’s patches: Target cell candidates for inulooligosaccharides in hochuekkito formula containing <scp>Atractylodis</scp> rhizoma. Traditional & Kampo Medicine. 2022. 9. 1. 32-40
Tatsuya Shirahata, Rintaro Miyaishi, Tatsuki Kitazoe, Masaya Saito, Yuki Taneoka, Shuhei Hidaka, Masaki Yokoyama, Takayori Tojima, Tatsuya Katsumi, Nozomu Hirata, et al. Preparation of Tenuifolin from Polygala senega L. Root Using a Hydrolytic Continuous Flow System under High-Temperature, High-Pressure Conditions. The Journal of Organic Chemistry. 2021. 86. 23. 16268-16277
Liufang Hu, Xiaojun Song, Takayuki Nagai, Marina Yamamoto, Yi Dai, Liangliang He, Hiroaki Kiyohara, Xinsheng Yao, Zhihong Yao. Chemical profile of Cimicifuga heracleifolia Kom. And immunomodulatory effect of its representative bioavailable component, cimigenoside on Poly(I:C)-induced airway inflammation. Journal of Ethnopharmacology. 2021. 267. 113615-113615
Satoshi Ideno, Yosuke Tanaka, Kayako Sasou, Haruna Hosaka, Hidenori Matsui, Hiroko Maruyama, Miki Tonooka, Mari Endo, Takayuki Nagai, Hiroyuki Seki, et al. Hochuekkito comprising Atractylodis lanceae rhizoma prevents pulmonary infection of Streptococcus pneumoniae in cyclophosphamide-treated mice through acceleration of anti-bacterial protein production. Traditional & Kampo Medicine. 2020. 7. 3. 166-179
Mayu Idehara, Yosuke Tanaka, Haruna Hosaka, Kayako Saso, Satoshi Ideno, Yuki Nakamura, Michiko Sekiya, Takayuki Nagai, Hiroaki Kiyohara. Inulooligosaccharides in Atractylodis lanceae rhizoma and Atractylodis rhizoma of hochuekkito formula are essential for regulation of the pulmonary immune system of immuno-compromised mice. Traditional & Kampo Medicine. 2020. 7. 2. 96-107

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MISC (127)：

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Books (1)：

Complement activating polysaccharides from medicinal herbs
Immunomodulatory Agents from Plant 1999

Works (10)：

和漢薬からの化粧品素材の探索
2002 - 2004
健康食品の科学的評価に関する研究
2002 - 2004
Useful materials for cosmetics from Japanese herbal medicine
2002 - 2004
Research on scientific evaluation of functional food
2002 - 2004
植物素材からの抗感染症薬の探索研究
2000 - 2004

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Professional career (1)：

doctor of pharmacy (Kitasato University)

Work history (4)：

2020/07 - 現在 Omura Satoshi Memorial Institute, Kitasato University Laboratory of Biochemical Pharmacology for Phytomedicine Professor
2001 - 2020/06 Kitasato Institute for Life Sciences, KItasato University Laboratory of Biochemical Pharmacology for Phytomedicine Professor
1982 - 2001 (社)北里研究所・東洋医学総合研究所
1982 - 2001 The Kitasato Institute, Oriental Medicine Research Center

Committee career (2)：

1994 - 2004 和漢医薬学会評議員
1999 - 2003 日本生薬学会編集委員

Awards (1)：

1997 - 日本生薬学会奨励賞

Association Membership(s) (4)：

日本生薬学会 , 日本糖質学会 , 日本薬学会 , 和漢医薬学会

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