Rchr
J-GLOBAL ID:200901050426944117
Update date: Nov. 11, 2024
Arima Takahiro
アリマ タカヒロ | Arima Takahiro
Affiliation and department:
Job title:
教授
Research field (3):
Obstetrics and gynecology
, Medical biochemistry
, Molecular biology
Research keywords (4):
人類遺伝学
, 分子生物学
, Human genetics
, Molecular Biology
Research theme for competitive and other funds (44):
- 2024 - 2028 Implantation organoid model using human multilevel stem cells and elucidation of immune tolerance mechanism
- 2021 - 2025 ヒト胎盤形成のエピゲノム制御と母体-胎盤間分子シグナルコミュニケーションの理解
- 2021 - 2023 ヒト胎盤幹細胞を用いた胚着床オルガノイドの創出と着床不全細胞治療への挑戦
- 2018 - 2021 Investigation of the molecular basis of extraembryonic lineage specification in humans
- 2017 - 2020 Epigenomic cohort study in the ART-derived children
- 2017 - 2019 Development of pregnancy hypertension model using human placental trophoblast stem cells
- 2015 - 2018 Exhaustive survey of development of oral function and health promotion factors on a large-scale birth cohort
- 2015 - 2018 Genomic imprinting in the human placenta
- 2015 - 2017 DNA methylation analyses in the human placenta cells
- 2014 - 2017 Epigenetic analyses in patients with imprinting disorders conceived by assisted reproduction technologies
- 2013 - 2015 Genomic imprinting
- 2012 - 2015 Functional analysis of a placenta-specific imprinted gene Gab1 in the placenta
- 2011 - 2014 Aberrant DNA methylation of imprinted loci in sperm from infertile men and the causal mechanism
- 2011 - 2013 Epigenetics of Cdx2 gene on the extraembryonic cell lineage and human trophoblastic stem cell.
- 2011 - 2012 新規ヒト・インプリンティング領域の探索と生殖補助医療への影響
- 2011 - 2012 The cell determination to extraembryonic tissue and the human placental stem cell.
- 2009 - 2010 ヒト生殖細胞系列におけるゲノムインプリンティング機構と生殖補助医療
- 2008 - 2009 胎盤幹細胞を用いた胎盤進化プロセスと哺乳類特異的ゲノムインプリント機構の解析
- 2007 - 2009 Evidence for an epigenetic mechanisms in ovarian cancer by the whole-genome tiling array system.
- 2002 - 2006 Molecular targeted therapy by inducing cancer cell senesence
- 2004 - 2005 絨毛トロホブラストにおけるNECC1シグナル伝達系とその機能の解明
- 2004 - 2005 ヒト胎盤形成におけるゲノムインプリント機構の役割について
- 2003 - 2004 Genomic imprinting and carcinogenesis
- 2002 - 2003 TGF-β応答性FOX C-1遺伝子の機能解析及びそのシグナル伝達路の同定
- 2001 - 2002 The analysis of OS-4 like gene and homeo protein like gene as a putative choriocarcinoma suppressor gene.
- 2001 - 2002 Genomic imprinting on the development of the human trophoblastic
- 2001 - 2001 HDAC阻害剤による癌細胞での老化誘導と癌抑制遺伝子の再発現
- 2001 - 2001 絨毛癌細胞における増殖・分化の制御機構と癌化
- 2000 - 2001 Molecular mechanism of endometrial carcinoma development and their application for the new molecular target therapy
- 1999 - 2001 Molecular mechanism of cell senescence
- 1997 - 1999 Molecular mechanism of endometrial cancer and its application to gene diagnosis
- 1997 - 1998 Transcriptional analysis of HPV16E7.
- 1996 - 1998 Analysis of signal transduction associate with carcinogenesis and progression in endometrial and ovarian carcinoma.
- 1996 - 1998 Development of new therapy for uterine cervical carcinoma
- 1996 - 1997 ヒト胎盤形成及び癌化とゲノムインプリンティング
- 1995 - 1997 Genetic Events Associated With Choriocarcinogenesis.
- 1995 - 1996 Establishment of gene diagnosis and therapy for Endometrial carcinoma.
- 1994 - 1995 Association of genetic imprinting with trophoblast differentiation and choriocarcinoma development.
- 新生児一過性糖尿病発症のメカニズムとインプリント機構の研究
- 胎盤形成におけるゲノムインプリンティング
- 絨毛癌の発生起源に関する研究
- Mechanism of TNDM and genomic imprinting
- Genomic imprinting on trophuoblast development
- Genetic origin of trophoblastic neoplasms
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Papers (144):
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Hidehiro Toh, Hiroaki Okae, Kenjiro Shirane, Tetsuya Sato, Hirotaka Hamada, Chie Kikutake, Daisuke Saito, Takahiro Arima, Hiroyuki Sasaki, Mikita Suyama. Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells. BMC genomics. 2024. 25. 1. 1050-1050
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Hidehiro Toh, Hiroaki Okae, Kenjiro Shirane, Tetsuya Sato, Hirotaka Hamada, Chie Kikutake, Daisuke Saito, Takahiro Arima, Hiroyuki Sasaki, Mikita Suyama. Epigenetic dynamics of partially methylated domains in human placenta and trophoblast stem cells. BMC Genomics. 2024. 25. 1
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Hiroaki Okae, Shun Shibata, Takahiro Arima. Common and uncommon findings in marmoset and human trophoblast stem cells. Cell stem cell. 2024. 31. 10. 1387-1388
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Shinobu Tsuchiya, Masahiro Tsuchiya, Haruki Momma, Kaoru Igarashi, Ryoichi Nagatomi, Masatoshi Saito, Takahiro Arima, Nobuo Yaegashi. Risk of self-harm ideation in mothers of children with orofacial cleft defects: the Japan environment and children's study. Frontiers in Global Women's Health. 2024. 5
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Aya Yamada, Haruki Momma, Nozomi Tatsuta, Kunihiko Nakai, Takahiro Arima, Chiharu Ota, Nobuo Yaegashi, Ryoichi Nagatomi. Association between maternal physical activity from pre-pregnancy to child-rearing and their children's physical activity in early childhood among Japanese. Journal of epidemiology. 2024
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MISC (187):
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JIANG Bin, 堀武志, 岡江寛明, 大杉勇人, 片桐さやか, 梨本裕司, 有馬隆博, 梶弘和. ヒト胎盤オルガノイドに対する歯周病原細菌曝露の影響の解析. 化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM). 2024. 49th
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柴田 峻, 小林 枝里, 有馬 隆博. 【図説 産婦人科医のための臨床遺伝学必修知識I】知っておきたいエピゲノムの基礎知識. 産婦人科の実際. 2023. 72. 8. 781-786
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柴田 峻, 小林 記緒, 岡江 寛明, 有馬 隆博. 胎盤発生と細胞運命決定機構. HORMONE FRONTIER IN GYNECOLOGY. 2023. 30. 1. 29-36
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JIANG Bin, 堀武志, 岡江寛明, 大杉勇人, 片桐さやか, 梨本裕司, 有馬隆博, 梶弘和. ヒト胎盤オルガノイドの作製と病原体曝露の影響の解析. 化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM). 2023. 48th
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リー ジアユンライアン, 堀武志, 岡江寛明, 梨本裕司, 有馬隆博, 梶弘和. マイクロ流体デバイスを用いたヒト胎盤モデルにおける灌流依存的細胞分化の解析. 化学とマイクロ・ナノシステム学会研究会講演要旨集(CD-ROM). 2023. 48th
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Patents (5):
Lectures and oral presentations (49):
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Modeling Embryo-Endometrial Interface Recapitulating Human Embryo Implantation
(IHEC Annual Meeting 2023 2023)
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ヒト胎盤幹細胞におけるエピジェネティクス制御と着床オルガノイドモデルの創出
(第31回日本胎盤学会学術集会 2023)
-
ヒト胎盤発生過程におけるエピジェネティクス制御と疾患との関連-ヒトTS細胞を用いた基礎的な研究-
(第43回日本妊娠高血圧学会学術集会 2023)
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胎児-母体アセンブロイドを用いたin vitroにおけるヒト胚着床現象の再現
(第41回日本受精着床学会総会・学術講演会 2023)
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妊娠高血圧症候群における細胞性栄養膜細胞を用いたマルチオミックス解析
(第30回日本胎盤学会学術集会 2022)
more...
Education (2):
- 1997 - 九州大学大学院医学系研究科博士課程修了(医学博士)
- - 1986 Tottori University Faculty of Medicine
Professional career (1):
- medical doctor (Kyushu University)
Work history (6):
Committee career (1):
Association Membership(s) (4):
日本生殖内分泌学会
, 日本人類遺伝学会
, 日本癌学会
, 日本産婦人科学会
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