Hayakawa Makio

ハヤカワマキオ | Hayakawa Makio

Affiliation and department：
Job title： Associate Professor

Research field (2)： Pharmacology , Pharmaceuticals - health and biochemistry

Research keywords (4)：衛生化学 , 細胞生物学 , 分子生物学 , Molecular cell Biology

Research theme for competitive and other funds (3)：

発がん・がん転移
酸素ストレスと情報伝達
Redox signaling

Papers (51)：

Tomofumi Fujino, Akihito Yokosuka, Harutaka Ichikawa, Toshiyuki Oshima, Yoshihiro Mimaki, Makio Hayakawa. AU-1 from Agavaceae plants downregulates the expression of glycolytic enzyme phosphoglycerate mutase. Journal of Natural Medicines. 2018. 72. 1. 342-346
Tomofumi Fujino, Ryosuke Sakamaki, Haruka Ito, Yumiko Furusato, Nami Sakamoto, Toshiyuki Oshima, Makio Hayakawa. Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line. JOURNAL OF TOXICOLOGICAL SCIENCES. 2017. 42. 3. 259-265
Tomofumi Fujino, Akihito Yokosuka, Hideaki Higurashi, Rina Yokokawa, Ryo Sakurai, Wataru Harashima, Yuichi Miki, Yasuyuki Fujiwara, Yoshihiro Mimaki, Makio Hayakawa. AU-1 from Agavaceae plants causes transient increase in p21/Cip1 expression in renal adenocarcinoma ACHN cells in an miR-34-dependent manner. JOURNAL OF NATURAL MEDICINES. 2017. 71. 1. 36-43
Tomofumi Fujino, Akiko Maruko-Ohtake, Yosuke Ohtake, Tomonori Kobayashi, Ken Ando, Airi Takeuchi, Yasuhito Ohkubo, Makio Hayakawa. Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells. JOURNAL OF TOXICOLOGICAL SCIENCES. 2015. 40. 4. 501-508
Akiko Takasuga, Kunio Sato, Ryouichi Nakamura, Yosuke Saito, Shinji Sasaki, Takehito Tsuji, Akio Suzuki, Hiroshi Kobayashi, Tamako Matsuhashi, Koji Setoguchi, et al. Non-synonymous FGD3 Variant as Positional Candidate for Disproportional Tall Stature Accounting for a Carcass Weight QTL (CW-3) and Skeletal Dysplasia in Japanese Black Cattle. PLoS genetics. 2015. 11. 8. e1005433

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MISC (10)：

井上圭三, 早川磨紀男. 井上圭三会頭に聞く. ファルマシア. 2004. 40. 4. 297-300
早川磨紀男. 発表論文の舞台裏プロジェクトメイト--旅する仲間. モレキュラ-メディシン. 2003. 40. 3. 340-345
早川磨紀男. 現代化学増刊39, ボディープランと器官形成, 浅島誠編, 東京化学同人, B5, 183頁, 4,200円. ファルマシア. 2001. 37. 9
早川磨紀男. セリンキナーゼとユビキチンリガーゼの共役(D・生化学, 衛生化学). ファルマシア. 1999. 35. 8. 830-831
E Zandi, DM Rothwarf, M Delhase, M Hayakawa, M Karin. The I kappa B kinase complex (IKK) contains two kinase subunits, IKK alpha and IKK beta, necessary for I kappa B phosphorylation and NF-kappa B activation. CELL. 1997. 91. 2. 243-252

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Lectures and oral presentations (4)：

FXRは肝細胞において肝細胞増殖因子(HGF)によりERK依存的に down-regulate される
(脂質生化学研究 2008)
HIFα以外の因子が Hypoxia に曝された肝細胞におけるFXR活性低下に関与する
(脂質生化学研究 2007)
低酸素ストレスにさらされた肝細胞におけるコレステロール代謝に関わる核内受容体 farnesoid X receptor の機能解析
(脂質生化学研究 2006)
Hypoxia に曝された肝細胞におけるFXR活性低下ならびに胆汁酸トランスポーター発現低下に対するHIF-1αの関与
(脂質生化学研究 2005)

Education (2)：

- 1985 The University of Tokyo Faculty of Pharmaceutical Sciences Department of Pharmacy
- 1985 The University of Tokyo Faculty of Pharmaceutical Science

Professional career (2)：

(BLANK) (The University of Tokyo)
(BLANK) (The University of Tokyo)

Work history (4)：

1996 - 1998 カリファルニア大学サンディエゴ校ポスドク
1996 - 1998 Post Doctoral Fellow at University of California., Saupiego
1987 - 1996 Setsunan University Faculty of Pharmaceutical Sciences
1987 - 1996 Research Assistant at Setsunan Unirersity

Association Membership(s) (3)：

日本分子生物学会 , 日本薬学会 , 日本生化学会

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