Art

J-GLOBAL ID：201702235112934340   Reference number：17A0776964

Farnesoid X receptor regulates the growth of renal adenocarcinoma cells without affecting that of a normal renal cell-derived cell line

ファルネソイドX受容体は正常腎細胞由来細胞株の増殖に影響を与えないが,腎腺癌の増殖を制御する

Author (7)： Fujino Tomofumi (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Sakamaki Ryosuke (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Ito Haruka (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Furusato Yumiko (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Sakamoto Nami (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Oshima Toshiyuki (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences) ,  Hayakawa Makio (Department of Hygiene and Health Sciences, School of Pharmacy, Tokyo University of Pharmacy and Life Sciences)
Material： Journal of Toxicological Sciences  (日本毒性学会学術年会プログラム・要旨集)
Volume： 42  Issue： 3  Page： 259-265(J-STAGE)  Publication year： 2017 
JST Material Number： Z0265B  ISSN： 0388-1350  Document type： Article
Article type： 原著論文  Country of issue： Japan (JPN)  Language： ENGLISH (EN)

Thesaurus term： *transcription factor ,...
Semi thesaurus term： *cytosol receptor ,...

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Author keywords (4)： Farnesoid X receptor ,  Cyclin-dependent kinase inhibitors ,  Carcinoma-specific cytotoxicity ,  Renal adenocarcinoma cells

JST classification (2)： Chemistry,biochemistry and pathology of tumors(=neoplasms)  (GE02030N) ,  Urogenital tumors(=neoplasms)  (GM04000S)

Reference (21)：

• el-Deiry, W.S., Tokino, T., Velculescu, V.E., Levy, D.B., Parsons, R., Trent, J.M., Lin, D., Mercer, W.E., Kinzler, K.W. and Vogelstein, B. (1993): WAF1, a potential mediator of p53 tumor suppression. Cell, 75, 817-825.
• Forman, B.M., Goode, E., Chen, J., Oro, A.E., Bradley, D.J., Perlmann, T., Noonan, D.J., Burka, L.T., McMorris, T., Lamph, W.W., Evans, R.M. and Weinberger, C. (1995): Identification of a nuclear receptor that is activated by farnesol metabolites. Cell, 81, 687-693.
• Fujino, T., Takeuchi, A., Maruko-Ohtake, A., Ohtake, Y., Satoh, J., Kobayashi, T., Tanaka, T., Ito, H., Sakamaki, R., Kashimura, R., Ando, K., Nishimaki-Mogami, T., Ohkubo, Y., Kitamura, N., Sato, R., Kikugawa, K. and Hayakawa, M. (2012): Critical role of farnesoid X receptor for hepatocellular carcinoma cell proliferation. J. Biochem., 152, 577-586.
• Fujino, T., Maruko-Ohtake, A., Ohtake, Y., Kobayashi, T., Ando, K., Takeuchi, A., Ohkubo, Y. and Hayakawa, M. (2015a) Farnesoid X receptor knockdown provides significant growth inhibition in hepatocellular carcinoma cells while it does not interfere with the proliferation of primary human hepatocyte-derived cells. J. Toxicol. Sci., 40, 501-508.
• Fujino, T., Kuroda, M., Matsuo, Y., Kubo, S., Tamura, C., Sakamoto, N., Mimaki, Y. and Hayakawa, M. (2015b): Cardenolide glycosides from the seeds of Digitalis purpurea exhibit carcinoma-specific cytotoxicity toward renal adenocarcinoma and hepatocellular carcinoma cells. Biosci. Biotechnol. Biochem., 79, 177-184.

Terms in the title (5)： ファルネソイドX受容体 ,  腎細胞 ,  細胞株 ,  増殖 ,  腎腺癌