Research field (3)：
Bioorganic chemistry
, Structural/physical organic chemistry
, Molecular biochemistry
Research keywords (6)：
全合成
, 構造解析
, 生体機能分子
, 繊毛虫
, 抗生物質
, Bioorganic Material Science
Research theme for competitive and other funds (23)：
2022 - 2026 原始的な繊毛虫における交配フェロモンの多様性とその受容機構の解明
2022 - 2025 Exploration of promising molecules derived from antimycin antibiotics with suppressive activity towards the production of inflammatory cytokines
2018 - 2020 Exploration into Chemical Communication Involved in Biological Phenomena of Ciliates
2016 - 2019 薬剤誘導型酸化ストレスによる薬剤排出ポンプの活性および遺伝子発現の制御
2013 - 2017 Chemical and genetic study of plant evolution and speciation in the Hengduan Mountains of China
2013 - 2016 Involvement of calcium signal in gene regulation related to drug exhaust
2006 - 2007 Analysis of tubulin metabolisms in fungi
2004 - 2006 Molecular mechanism of chemical self-defense of the protozoan ciliates.
2002 - 2003 STRUCTURE-ACTIVITY RELATION SHIPS OF UK-2a, A NOVEL ANTIFUNGAL ANTIBIOTIC FROM Streptomyces sp.517-02
2000 - 2002 Biologically Active Key Compounds of Protozoan Ciliates
1999 - 2002 Molecular Mechanism on the Conjugation of Ciliate Blepharisma
2000 - 2001 THE EFFECT CHARACTERISTICS OF A NOVEL ANTIFUNGAL AGENT, UK-2A
1998 - 微生物が産出する特異な生物活性を有する化合物に関する研究
1993 - 1994 繊毛虫ブレファリズマの接合に関する有機化学的研究
1994 - フルオロビニル基を有する新規光学活性アミノ酸を組み込んだペプチドの合成と機能解析
1992 - 生物活性天然物の合成
1992 - 含フッ素生体物質類似体の合成とその特性
Structure Elucidation of Organic Compounds
Structure & Activity Relationship of antifungal Antibiotics
Synthesis of Biologically Active Natural Products
Synthesis and Properties of Fluorinated Bio-molecules Mimics
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Papers (43)：
Yoshinosuke Usuki, Ryota Abe, Kazuki Nishiguchi, Tetsuya Satoh, Harumi Aono, Toshihiko Nogawa, Yushi Futamura, Hiroyuki Osada, Izumi Yoshida, Kazuhiro Fujita, et al. Total synthesis, stereochemical assignment, and biological evaluation of opantimycin A and analogues thereof. Organic & Biomolecular Chemistry. 2024
Rikuto Tanaka, Shiho Ochiai, Asumi Sakai, Yoshinosuke Usuki, Bubwoong Kang, Tetsuro Shinada, Tetsuya Satoh. Ligand-Dependant Selective Synthesis of Mono- and Dialkenylcarbazoles through Rhodium(III)-Catalyzed C-H Alkenylation. Chemistry - An Asian Journal. 2023. 18. 4
Qiang Zhang, Seigo Terawaki, Daisuke Oikawa, Yoshinori Okina, Yoshinosuke Usuki, Hidefumi Ito, Fuminori Tokunaga. Suppression of Linear Ubiquitination Ameliorates Cytoplasmic Aggregation of Truncated TDP-43. Cells. 2022. 11. 15
Y Tsukuda, N Mizuhara, Y Usuki, Y Yamaguchi, A Ogita, T Tanaka, K Fujita. Structure-activity relationships of antifungal phenylpropanoid derivatives and their synergy with n-dodecanol and fluconazole. Letters in applied microbiology. 2022. 74. 3. 377-384
Yasuhito Inai, Yoshinosuke Usuki, Tetsuya Satoh. Synthesis of Benzo-Fused Cyclic Compounds via Rhodium-Catalyzed Decarboxylative Coupling of Aromatic Carboxylic Acids with Alkynes. Synthesis (Germany). 2021. 53. 17. 3029-3036
