Okamoto Kazuki

オカモトカヅキ | Okamoto Kazuki

Affiliation and department：

Research field (1)： Medical biochemistry

Research keywords (7)：新規抗炎症薬の開発 , グルココルチコイド受容体の分子作用機構 , NF-kB阻害薬 , 抗炎症薬 , 核内受容体 , グルココルチコイド , Molecular Mechanisms of Glucocorticoid-Receptor

Research theme for competitive and other funds (14)：

2021 - 2024 elucidation of the mechanism of labor, derived from the intrinsic NF-kB inhibitor protein
2021 - 2024 Mechanism of implantation by endogenous NF-kB transcriptional inhibitor (MTI-II)
2017 - 2019 新規NF-kB転写阻害因子MTI-IIの抗炎症作用を担う6アミノ酸ペプチドに基づくペプチド性抗炎症薬の開発
2014 - 2016 Development of novel diagnosis of systemic lupus erythematosus by measurement of splicing activity
2013 - 2015 疾患に関連する糖蛋白質の複数同時探索系の確立

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Papers (93)：

Kenji Takami, Kazuki Okamoto, Yuki Etani, Makoto Hirao, Akira Miyama, Gensuke Okamura, Atsushi Goshima, Taihei Miura, Takuya Kurihara, Yuji Fukuda, et al. Anti-NF-κB peptide derived from nuclear acidic protein attenuates ovariectomy-induced osteoporosis in mice. JCI insight. 2023. 8. 22
Toshinori Oozeki, Tadashi Nakai, Kazuki Kozakai, Kazuki Okamoto, Shun’ichi Kuroda, Kazuo Kobayashi, Katsuyuki Tanizawa, Toshihide Okajima. Functional and structural characterization of a flavoprotein monooxygenase essential for biogenesis of tryptophylquinone cofactor. Nature Communications. 2021. 12. 1. 933-933
Shizu Hirata-Tsuchiya, Shigeki Suzuki, Kazuki Okamoto, Noriko Saito, Hang Yuan, Satoru Yamada, Eijiro Jimi, Hideki Shiba, Chiaki Kitamura. A small nuclear acidic protein (MTI-II, Zn2+-binding protein, parathymosin) attenuates TNF-α inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-κB p65 complex to Smad binding element. Molecular and Cellular Biochemistry. 2020. 469. 1-2. 133-142
Hirotaka Tsuno, Mitsumi Arito, Naoya Suematsu, Toshiyuki Sato, Atsushi Hashimoto, Toshihiro Matsui, Kazuki Omoteyama, Masaaki Sato, Kazuki Okamoto, Shigeto Tohma, et al. A proteomic analysis of serum-derived exosomes in rheumatoid arthritis. BMC Rheumatology. 2018. 2. 1. 35-35
Masaki Kato, Susumu Hamada-Tsutsumi, Chiaki Okuse, Aiko Sakai, Nobuyuki Matsumoto, Masaaki Sato, Toshiyuki Sato, Mitsumi Arito, Kazuki Omoteyama, Naoya Suematsu, et al. Effects of vaccine-acquired polyclonal anti-HBs antibodies on the prevention of HBV infection of non-vaccine genotypes. Journal of Gastroenterology. 2017. 52. 9. 1051-1063

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MISC (173)：

平田志津, 鈴木茂樹, 岡本一起, 西藤法子, 山田聡, 柴秀樹, 北村知昭. NF-κB阻害薬MTI-IIはp65-Smad4複合体のSmad binding elementへの結合に関与する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2019. 151回. 108-108
平田志津, 鈴木茂樹, 岡本一起, 西藤法子, 山田聡, 柴秀樹, 北村知昭. NF-κB阻害薬MTI-IIはp65-Smad4複合体のSmad binding elementへの結合に関与する. 特定非営利活動法人日本歯科保存学会学術大会プログラムおよび講演抄録集. 2019. 151回. 108-108
岡本一起, 立松健司, 黒田俊一. NF-κB転写阻害因子(MTI-II)由来6アミノ酸ペプチド(sMPAID)の抗炎症作用. ビタミン. 2019. 93. 4. 189-189
岡本一起, 立松健司, 黒田俊一. NF-κBコリプレッサー(MTI-II)の作用部位由来6アミノ酸ペプチドのin vivo抗炎症作用. 日本生化学会大会プログラム・講演要旨集. 2018. 91回. [1P-329]
岡本一起. NF-κB 転写阻害因子MTI- II由来6 アミノ酸ペプチドのラット結膜炎抑制試験. ビタミン. 2018. 92. 11. 518-519

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Patents (3)：

ペプチド、ポリヌクレオチド、ベクター、形質転換体、NFκB阻害剤、及びNFκB亢進性疾患の治療剤
NFκB作用抑制剤及び抗炎症剤並びにステロイド作用増強剤
NFkB TRANSCRIPTIONAL ACTIVITY INHIBITORY AGENT AND ANTI-INFLAMMATORY AGENT AND A STEROID ACTION ENHANCING AGENT

Books (28)：

副作用の少ないペプチド抗炎症薬の開発
技術情報協会 2017
核内受容体(2)新しく見出した特性に基づくグルココルチコイド・レセプターの超高純度精製法
廣川書店 2005
核内受容体(1)グルココルチコイド受容体
廣川書店 2005
シークエンスデータ処理の実際
生化学・分子生物学実習書(小日向商事) 2001
シークエンスデータの解析と塩基配列の決定
生化学・分子生物学実習書(小日向商事) 2001

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Education (3)：

1981 - 1984 Osaka University Graduate School of Medicine
1979 - 1981 Osaka University Graduate School of Medicine
1975 - 1979 Osaka University School of Science

Professional career (2)：

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Work history (8)：

2022/04 - 現在 Osaka University Graduate School of Medicine
2017/04 - 2022/03 Osaka University The Institute of Scientific and Industrial Research
2006/04 - 2017/03 St.Marianna University School of Medicine Graduate School of Medicine Medical Research Division
1995/04 - 2006/03 St.Marianna University School of Medicine Graduate School of Medicine Medical Research Division
1994/05 - 1995/03 St.Marianna University School of Medicine Graduate School of Medicine Medical Research Division

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Association Membership(s) (1)：

日本ビタミン学会

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