Art

J-GLOBAL ID：202002276487340152   Reference number：20A1267822

A small nuclear acidic protein (MTI-II, Zn²⁺-binding protein, parathymosin) attenuates TNF-α inhibition of BMP-induced osteogenesis by enhancing accessibility of the Smad4-NF-κB p65 complex to Smad binding element

小核酸性蛋白質(MTI-II,Zn2+結合蛋白質,パラチモシン)はSmad結合要素へのSmad4-NF-κB p65複合体の接近性増強によりBMP誘導骨形成のTNF-α阻害を減弱する【JST・京大機械翻訳】

Author (11)： Hirata-Tsuchiya Shizu (Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Hirata-Tsuchiya Shizu (Division of Endodontics and Restorative Dentistry, Department of Oral Function, Kyushu Dental University, Fukuoka, Japan) ,  Suzuki Shigeki (Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Suzuki Shigeki (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Okamoto Kazuki (The Institute of Scientific and Industrial Research, Osaka University, Osaka, Japan) ,  Saito Noriko (Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Yuan Hang (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Yamada Satoru (Department of Periodontology and Endodontology, Tohoku University Graduate School of Dentistry, Sendai, Japan) ,  Jimi Eijiro (Oral Health/Brain Health/Total Health Research Center, Faculty of Dental Science, Kyushu University, Fukuoka, Japan) ,  Shiba Hideki (Department of Biological Endodontics, Graduate School of Biomedical and Health Sciences, Hiroshima University, Hiroshima, Japan) ,  Kitamura Chiaki (Division of Endodontics and Restorative Dentistry, Department of Oral Function, Kyushu Dental University, Fukuoka, Japan)
Material： Molecular and Cellular Biochemistry
Volume： 469  Issue： 1-2  Page： 133-142  Publication year： 2020 
JST Material Number： C0452B  ISSN： 0300-8177  CODEN： MCBIB8  Document type： Article
Article type： 原著論文  Country of issue： Germany, Federal Republic of (DEU)  Language： ENGLISH (EN)

Abstract/Point： Abstract: Pro-inflammatory cyt...

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Thesaurus term： peptide ,  Inflammation ,  anti-inflammatory action ,  *osteogenesis ,  *complex (substance) ,  promoter (genetics) ,  in vitro experiment ,  *TNF alpha ,  *NF-kappaB ,  osteogenic factor ,  Osteocalcin ,  *Smad Proteins ,  overexpression ,  Signal Transduction
Semi thesaurus term： cellular signal transduction ,  *p65 , 【Automatic Indexing@JST】

Author keywords (5)： MTI-II ,  Osteogenesis ,  Inflammation ,  Smad4 ,  p65

JST classification (2)： Cell physiology in general  (EF02010S) ,  Gene expression  (EC02040Q)

Terms in the title (18)： 小核 ,  酸性 ,  蛋白質 ,  結合蛋白質 ,  SMAD ,  要素 ,  Smad4 ,  NF-κB ,  p65 ,  複合体 ,  接近性 ,  増強 ,  BMP ,  誘導 ,  骨形成 ,  TNF-α ,  阻害 ,  減弱