Rchr
J-GLOBAL ID：200901078750548510
Update date: Apr. 12, 2024
Okamoto Yoshinari
オカモト ヨシナリ | Okamoto Yoshinari
Affiliation and department：
Job title：
Assistant Professor
Research field (1)：
Pharmaceuticals - chemistry and drug development
Research theme for competitive and other funds (12)：
- 2016 - 2018 Development of a novel brain protectant
- 2014 - 2017 癌に関与する亜鉛蛋白質を標的とした抗癌剤の創製
- 2014 - 2016 Design and synthesis of a compound targeting amyloid beta aiming at the cure of Alzheimer's disease
- 2011 - 2014 Development of medicinal molecules having biologically functions targeting the PI3K/Akt pathway and the TGF-b/Smad pathway
- 2011 - 2013 Development of inhibitors of cancer cell invasion targetting to ADAM17 or transcription factor Snail.
- 2008 - 2010 Development of zinc chelators to inhibit function of zinc protein participating in invasion and metastasis of cancer cell
- 2008 - 2010 Design of DNA-cleaving and -crosslinking agents based on NFκB and HMGA proteins aiming at the application to cancer therapy
- 2007 - 2008 Regulation of HIV replication by inositol phosphates
- 2005 - 2007 Development of zinc chelators with protein specificity aiming at molecular target therapy of cancer
- 2003 - 2004 Molecular design of anti-AIDS drugs targeting the viral and host zinc proteins
- 2003 - 2003 Rasファルネシルトランスフェラーゼの亜鉛部位を標的とした抗がん剤の創製
- 1999 - 2001 Molecular Design of Ras Farnesyltransferase Inhibitors
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Papers (38)：
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Hiroshi Tateishi, Takuma Chinen, Ryota Fukuda, Mohamed O Radwan, Kazunori Shimagaki, Ryoko Koga, Takashi Masuda, Yoshinari Okamoto, Arisa Sakamoto, Shogo Misumi, et al. HIV-1 Gag MA domain binds to cardiolipin in a binding mode distinct from virus assemble mediator PI(4,5)P2. Chemical biology & drug design. 2023. e14401
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Tsugumasa Toma, Junpei Yamashita, Mohamed O. Radwan, Mostafa M. Badran, Takuya Masunaga, Masahiro Kamo, Ryoko Koga, Yoshinari Okamoto, Hiroshi Tateishi, Masami Otsuka, et al. Tranilast-tyrosine hybrid molecule exhibits dual activity: suppression of epithelial-mesenchymal transition and induction of cytotoxicity in cancer cells. Medicinal Chemistry Research. 2022. 31. 9. 1584-1593
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Hiroshi Tateishi, Mika Tateishi, Mohamed O. Radwan, Takuya Masunaga, Kosuke Kawatashiro, Yasunori Oba, Misato Oyama, Natsuki Inoue-Kitahashi, Mikako Fujita, Yoshinari Okamoto, et al. A new inhibitor of ADAM17 composed of a zinc-binding dithiol moiety and a specificity pocket-binding appendage. Chemical and Pharmaceutical Bulletin. 2021. 69. 11. 1123-1130
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Teruya Nakamura, Chie Hashikawa, Kohtaro Okabe, Yuya Yokote, Mami Chirifu, Sachiko Toma-Fukai, Narushi Nakamura, Mihoko Matsuo, Miho Kamikariya, Yoshinari Okamoto, et al. Structural analysis of TIFA: Insight into TIFA-dependent signal transduction in innate immunity. Scientific reports. 2020. 10. 1. 5152-5152
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Nao Nishimura, Mohamed O Radwan, Masayuki Amano, Shinya Endo, Eri Fujii, Hironori Hayashi, Shikiko Ueno, Niina Ueno, Hiro Tatetsu, Hiroyuki Hata, et al. Novel p97/VCP inhibitor induces endoplasmic reticulum stress and apoptosis in both bortezomib-sensitive and -resistant multiple myeloma cells. Cancer science. 2019. 110. 10. 3275-3287
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MISC (38)：
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N. Nishimura, M. O. Radwan, M. Amano, S. Endo, S. Ueno, N. Ueno, H. Tatetsu, H. Hata, Y. Okamoto, M. Matsuoka, et al. NOVEL COMPOUND, OSSL_325096, INDUCES APOPTOSIS IN MULTIPLE MYELOMA CELLS THROUGH VCP INHIBITION. HAEMATOLOGICA. 2017. 102. 495-495
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V. H. Luong, T. Chino, A. Tokuriki, N. Oyama, Y. Sasaki, D. Ogura, S. Niwa, M. Fujita, Y. Okamoto, M. Otsuka, et al. A novel small compound HPH-15 antagonizes TGF-beta/Smad signaling and ameliorates experimental skin fibrosis. JOURNAL OF INVESTIGATIVE DERMATOLOGY. 2017. 137. 5. S46-S46
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Satomi Ida, Kana Iwamaru, Mikako Fujita, Yoshinari Okamoto, Yuri Kudo, Hiromasa Kurosaki, Masami Otsuka. L-Histidyl-glycyl-glycyl-L-histidine. Amino-acid structuring of the bleomycin-type pentadentate metal-binding environment capable of efficient double-strand cleavage of plasmid DNA. BIOORGANIC CHEMISTRY. 2015. 62. 8-14
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Taha F. S. Ali, Kana Iwamaru, Halil Ibrahim Ciftci, Ryoko Koga, Masahiro Matsumoto, Yasunori Oba, Hiromasa Kurosaki, Mikako Fujita, Yoshinari Okamoto, Kazuo Umezawa, et al. Novel metal chelating molecules with anticancer activity. Striking effect of the imidazole substitution of the histidine-pyridine-histidine system. BIOORGANIC & MEDICINAL CHEMISTRY. 2015. 23. 17. 5476-5482
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Ali Taha, 岩丸 佳奈, Ciftci Halil, 古賀 涼子, 黒崎 博雅, 藤田 美歌子, 岡本 良成, 秀 拓一郎, 牧野 敬史, 倉津 純一, et al. 抗癌活性を持つ新規の金属キレート分子(Novel metal chelating molecules with anticancer activity). 日本薬学会年会要旨集. 2015. 135年会. 2. 137-137
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Patents (2)：
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ロキソプロフェン誘導体及びそれを含有する医薬
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Loxoprofen derivative and pharmaceutical containing same
Books (1)：
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PHドメインを機軸としたmyo-イノシトール三リン酸センサーの構築
シュプリンガー・フェアラーク東京・ケミカルバイオロジー・ケミカルゲノミクス 2005
Lectures and oral presentations (59)：
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HNEを標的とした新規脳保護薬
(日本薬学会第138年会 2018)
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A Novel cerebral protecting Agent targeting HNE
(2018)
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抗 HIV 剤 BMMP の作用機序解明
(日本薬学会第137年会 2017)
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DHMEQを基盤とした新しい生物活性物質の設計と合成,および機能解析
(第33回日本薬学会九州支部大会 2016)
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癌に関与する亜鉛蛋白質阻害剤の開発
(日本・トルコ 薬学・生命科学国際シンポジウム 2016)
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Works (5)：
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イノシトールリン酸によるHIV複製の制御
2007 - 2008
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蛋白質特異性をもった亜鉛キレーターの創製とがん分子標的治療への展開
2005 - 2008
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エイズウイルスおよび宿主のもつ亜鉛蛋白質を標的とした抗エイズ医薬の分子設計
2003 - 2005
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Rasファルネシルトランスフェラーゼの亜鉛部位を標的とした抗がん剤の創製
2003 - 2004
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Rasファルネシルトランスフェラーゼ阻害物質の分子設計
1999 - 2002
Education (2)：
- - 1987 Kumamoto University School of Pharmacy
- - 1987 Kumamoto University Faculty of Pharmaceutical Science
Professional career (1)：
- Doctor of Pharmaceutical Science
Work history (10)：
- 2010 - Kumamoto University Faculty of Life Sciences
- 2010 - Assistant Professor,Faculty of Life Sciences(Pharmaceutical sciences group),Kumamoto University
- 2007 - 2009 助教
- 2007 - 2009 Assistant Professor,
- 2003 - 2007 助手
- 2003 - 2007 Research Associate,
- 2001 - 2003 助手
- 2001 - 2003 Research Associate,
- 1987 - 2001 教務職員
- 1987 - 2001 Others,
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