Rchr
J-GLOBAL ID:200901082029258699
Update date: Jul. 16, 2024
Terasaki Tetsuya
Terasaki Tetsuya
Research field (6):
Cell biology
, Neurology
, Pharmacology
, Pharmaceuticals - health and biochemistry
, Clinical pharmacy
, Pharmaceuticals - analytical and physicochemistry
Research keywords (20):
Blood-Brain Barrier
, Blood-Ocular Barrier
, Transporter Proteomics
, Pharmacoproteomics
, Blood-Spinal Cord Barrier
, Blood-arachnoid barrier
, ドラッグデリバリ-
, 条件的不死化細胞
, 中枢解毒
, 排出輸送系
, 脳毛細血管
, ABCトランスポーター
, Brain Efflux Index法
, 有機アニオン輸送系
, 血液脳脊髄液関門
, 脳毛細血管内皮細胞
, 脳
, P-糖蛋白
, 輸送担体
, 血液脳関門
Research theme for competitive and other funds (48):
- 2017 - 2020 Study of human brain barrier transport mechanism based global and targeted proteomics
- 2016 - 2018 Exploration of blood biomarker for glioblastoma
- 2016 - 2018 Investigation of contribution of novel tight junction molecule at the two big central nervous system barriers and its usefulness as a therapeutic target for multiple sclerosis
- 2016 - 2018 Amino acid transporter-based drug development for cerebral creatine deficiency syndrome
- 2014 - 2016 Molecular subclassification of glioblastoma based on the absolute quantitative proteomics
- 2013 - 2016 Analysis and manipulation of acellular barrier in human blood-nerve barrier
- 2012 - 2016 Clarification of molecular mechanisms of the blood-brain barrier plasticity based on quantitative targeted absolute proteomics
- 2012 - 2014 Quantitative targeted absolute proteomics-based diagnostics for personalized cancer chemotherapy
- 2009 - 2011 Artificial control of blood-nerve barrier : an approach toward the novel therapeutics of intractable human peripheral nervous system disorders
- 2010 - 2010 小分子生体内挙動を制御する因子の組織・臓器階層における網羅的解析
- 2006 - 2009 PROTEOMICS-BASED ANALYSIS OF BLOOD-BRAIN BARRIER TRANSPORT SYSTEM
- 2005 - 2009 Physiological role of the blood-brain barrier transportsome
- 2006 - 2008 Blood-brain barrier and blood-nerve barrier as targets of novel therapeutic strategies for neurological disorders
- 2005 - 2007 血液脳関門輸送の分子生物学とその薬物送達への応用
- 2004 - 2006 Molecular pharmacological study for characterization of new identified iropioid receptor subclass
- 2004 - 2006 Analysis of blood-brain barrier transport system as the CNS elimination system for neurotoxins
- 2005 - 2005 蛍光標識化MRP4/ABCC4を用いた新薬スクリーニング系の開発
- 2005 - 2005 アミロイドβ蛋白の脳関門輸送
- 2002 - 2005 Physiological study on the transport functions at the blood-brain barrier relating to neural disorders.
- 2003 - 2004 網膜ペリサイト分泌血管内皮細胞増殖抑制因子の同定
- 2003 - 2004 Antioxidants transport via GLUT1 at the blood-retinal barrier
- 2000 - 2001 Development of new drug screening system using the blood-brain barrier transporter gene expression
- 2000 - 2001 cDNA cloning of blood-brain barrier neurotransmitter transporter and analysis of its physiological function
- 1998 - 1999 トランスゲニックマウスおよびラットを用いたin vitro生体組織再構築系の開発
- 1998 - 1999 Development of in vitro blood-brain barrier culture system from temperature sensitive SV40T antigen gene transgenic animal
- 1998 - 1999 Functional multiplicity of blood-brain barrier transporters as a detoxifying system of the brain
- 1998 - 1998 脈絡上皮細胞の培養細胞株の樹立
- 1998 - 1998 血液脳関門における薬剤排出輸送系の生理的意義
- 1997 - 1998 腫瘍選択的なエネルギ-代謝遮断機構に基づいた抗がん剤の抗腫瘍効果の最適化
- 1997 - 1997 ポリオウイルスの血液脳関門透過機構
- 1997 - 1997 血液脳関門における薬剤排出輸送系の生理的意義
- 1996 - 1997 Development of a method to predict in vivo drug metabolism and excretion from in vitro data with human hepatic tissues and/or recombinant proteins
- 1996 - 1997 Molecular design of drug efflux system modulator at blood-brain barrier
- 1996 - 1996 ドラッグデリバリ-の空間的・時間的制御
- 1995 - 1996 Development of Pharmacokinetic and Safety Assessment of in vivo Virus Infection and Vaccine Therapy
- 1995 - 1995 抗癌剤の前臨床デ-タを基にしたヒトにおける動態、最大耐用量、抗腫瘍効果の予測
- 1994 - 1995 サイトカイン類の効率的な薬効発現を目指したドラッグデリバリ-システムの開発
- 1994 - 1995 Prediction of hepatobiliary transport of drugs : Contribution of carrier-mediated transport in the detoxication of xenobiotics
- 1994 - 1995 Drug Delivery to the Brain Using Cell Adhesion Molecule
- 1994 - 1994 ドラッグデリバリ-の空間的・時間的制御
- 1994 - 1994 抗癌剤の最適投与計画の作成:骨髄毒性の定量化とその回避
- 1992 - 1993 薬物組織からの汲み出し阻害を利用した脳および腫瘍への薬物デリバリ-システムの開発--生理学的薬物速度論の応用--
- 1992 - 1993 Clarification of transcellular transport mechanism of drugs utilizing tissue cultured cell systems
- 1992 - 1992 アフリカツメガエル卵母細胞発現系を用いた薬物輸送機構の分子論的解析
- 1991 - 1991 脳腫瘍時における血液ー脳関門の機能障害と制がん剤の腫瘍選択的デリバリ-
- 1991 - 1991 初代培養脳毛細血管内皮細胞系を用いた薬物輸送
- 1990 - 1990 細胞膜担体輸送系の基質構造認識特性を利用したドラッグデリバリ-
- 1989 - 1989 エンドサイト-シス機構を利用した脳へのペプチドデリバリ-
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Papers (450):
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Hiromu Ishiguro, Tadahaya Mizuno, Yasuo Uchida, Risa Sato, Hayate Sasaki, Shumpei Nemoto, Tetsuya Terasaki, Hiroyuki Kusuhara. Characterization of proteome profile data of chemicals based on data-independent acquisition MS with SWATH method. NAR Genomics and Bioinformatics. 2023. 5. 1
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Marie-Pierre Dehouck, Masanori Tachikawa, Yutaro Hoshi, Kotaro Omori, Claude-Alain Maurage, Guillaume Strecker, Lucie Dehouck, Marie-Christine Boucau, Yasuo Uchida, Fabien Gosselet, et al. Quantitative Targeted Absolute Proteomics for Better Characterization of an In Vitro Human Blood-Brain Barrier Model Derived from Hematopoietic Stem Cells. Cells. 2022. 11. 24. 3963-3963
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Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi. Proteomics-Based Transporter Identification by the PICK Method: Involvement of TM7SF3 and LHFPL6 in Proton-Coupled Organic Cation Antiport at the Blood-Brain Barrier. Pharmaceutics. 2022. 14. 8. 1683-1683
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Kristiina M. Huttunen, Tetsuya Terasaki, Arto Urtti, Ahmed B. Montaser, Yasuo Uchida. Pharmacoproteomics of Brain Barrier Transporters and Substrate Design for the Brain Targeted Drug Delivery. Pharmaceutical Research. 2022. 39. 7. 1363-1392
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Hina Takeuchi, Masayoshi Suzuki, Ryohei Goto, Kenta Tezuka, Holger Fuchs, Naoki Ishiguro, Tetsuya Terasaki, Clemens Braun, Yasuo Uchida. Regional Differences in the Absolute Abundance of Transporters, Receptors and Tight Junction Molecules at the Blood-Arachnoid Barrier and Blood-Spinal Cord Barrier among Cervical, Thoracic and Lumbar Spines in Dogs. Pharmaceutical Research. 2022. 39. 7. 1393-1413
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MISC (214):
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Tomohiro Nishimura, Yuichiro Sano, Yu Takahashi, Saki Noguchi, Yasuo Uchida, Akinori Takagi, Takahiro Tanaka, Satomi Katakura, Emi Nakashima, Masanori Tachikawa, et al. Quantification of ENT1 and ENT2 Proteins at the Placental Barrier and Contribution of These Transporters to Ribavirin Uptake. Journal of pharmaceutical sciences. 2019. 108. 12. 3917-3922
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内田康雄, 臼井拓也, 寺崎哲也. 中枢疾患時の血液脳関門P糖タンパク質の機能変動機構の解明と中枢関門創薬への新展開. 医学のあゆみ. 2019. 271. 1. 104-111
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Yijun Pan, Kotaro Omori, Izna Ali, Masanori Tachikawa, Tetsuya Terasaki, Kim L.R. Brouwer, Joseph A. Nicolazzo. Increased Expression of Renal Drug Transporters in a Mouse Model of Familial Alzheimer's Disease. Journal of Pharmaceutical Sciences. 2019. 108. 2484-2489
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川原田 翔平, 内田 康雄, 玉井 翔, 中田 光俊, 寺崎 哲也. 網羅的定量プロテオミクスSWATH法を用いた神経膠芽腫における初発と再発腫瘍組織のタンパク質発現解析. 日本薬剤学会年会講演要旨集. 2019. 34年会. 160-160
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樋口友也, 内田康雄, 内田康雄, 加賀美智史, 城田松之, 城田松之, 三枝大輔, 三枝大輔, 小柴生造, 小柴生造, et al. 次世代型プロテオミクスによる妊娠高血圧腎症の診断マーカーの同定. 日本薬学会東北支部大会講演要旨集. 2019. 58th
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Professional career (1):
- Ph.D. (University of Tokyo)
Work history (17):
- 2020/03 - 現在 Tohoku University
- 2015/04 - 2020/03 Tohoku University
- 2012/12 - 2020/03 Tohoku University
- 2010/04 - 2020/03 Tohoku University
- 1999/04 - 2020/03 東北大学 大学院・薬学研究科 教授
- 2011/10 - 2014/03 Tohoku University
- 2008/04 - 2011/03 Tohoku University
- 2010/09 - 2010/09 University D'Artois Invited Professor
- 2008/04 - 2010/03 東北大学 大学院・薬学研究科 副研究科長
- 2006/11 - 2009/03 Tohoku University
- 1999/07 - 2006/03 Tohoku University New Industry Creation Hatchery Center
- 1996/04 - 1999/03 Tohoku University Faculty of Pharmaceutical Sciences
- 1992/10 - 1994/03 The University of Tokyo Faculty of Pharmaceutical Sciences
- 1990/04 - 1992/09 Kanazawa University Faculty of Pharmaceutical Sciences
- 1985/04 - 1990/03 Kanazawa University Faculty of Pharmaceutical Sciences
- 1985/07 - 1987/06 文部省 在外研究員(乙種)
- 1982/04 - 1985/03 Kanazawa University Faculty of Pharmaceutical Sciences
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Awards (14):
- 2018/05 - International Society for the Study of Xenobiotics International Society for the Study of Xenobiotics Asia Pacific Scientific Achievement Award
- 2017/11 - University of Michigan College of Pharmacy The inaugural Allen J. Sedman Lecture Award in Pharmaceutical Sciences
- 2016/11 - Clarivate Analytics Highly Cited Researchers 2016 (Pharmacology & Toxicology)
- 2014/03 - The Pharmaceutical Society of Japan The Pharmaceutical Society of Japan Award
- 2013/05 - The Government of Japan The Medal of Honor with Purple Ribbon
- 2010/11 - The American Association of Pharmaceutical Scientists Meritorious Manuscript Award Quantitative atlas of membrane transporter proteins: Development and application of a highly sensitive simultaneous LC/MS/MS method combined with novel in-silico peptide selection criteria
- 2007/10 - The Japanese Society of Study for Xenobiotics The Japanese Society of Study for Xenobiotics Award
- 2007/05 - The Academy of Pharmaceutical Science and Technology, Japan The Academy of Pharmaceutical Science and Technology, Japan Award
- 2004/11 - The American Association of Pharmaceutical Scientists Fellow
- 1996/10 - The American Association of Pharmaceutical Scientists Meritorious Manuscript Award Transcellular transport of benzoic acid across Caco-2 cells by a pH-dependent and carrier-mediated transport mechanism
- 1994/05 - 富山県未来財団 富山賞
- 1992/03 - The Pharmaceutical Society of Japan Awards for Young Scientists
- 1991/09 - The Japanese Society for the Study of Xenobiotics Awards for Young Scientists
- 1985/02 - American Pharmaceutical Association Ebert Prize Pharmacokinetic study on the mechanism of tissue distribution of doxorubicin: Interorgan and interspecies variation of tissue-to-plasma partition coefficients in rats, rabbits and guinea pigs
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