Rchr
J-GLOBAL ID：200901086287169019   Update date: Nov. 07, 2023

Komatsu Yasuo

コマツ ヤスオ | Komatsu Yasuo
Affiliation and department：
National Institute of Advanced Industrial Science and Technology (AIST)

About National Institute of Advanced Industrial Science and Technology (AIST)


Other affiliations (1)：
  • Hokkaido University
Homepage URL  (1)： https://unit.aist.go.jp/bpri/
Research field  (3)： Pharmaceuticals - chemistry and drug development ,  Molecular biology ,  Biochemistry
Research keywords  (8)： ribozyme ,  antisense ,  核酸医薬 ,  oligonucleotide ,  microRNA ,  RNA ,  DNA ,  nucleic acid
Research theme for competitive and other funds  (17)：
  • 2020 - 2023 RNA分解酵素・アンチセンスの細胞内分子複合体化と長鎖RNA機能制御への応用
  • 2019 - 2023 高分子間相互作用を制御する合成機能分子を論理的・効率的に創出する方法論の確立
  • 2019 - 2022 損傷塩基が誘発する遠隔作用変異:損傷部位から離れた塩基に生じる変異の生成機構
  • 2015 - 2019 三次元多様性を分子設計上の鍵概念とする論理的創薬方法論の確立
  • 2016 - 2018 遠隔作用変異の生成・抑制の分子機構
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Papers (106)：
  • Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi. Synthesis of Crosslinked 2′-OMe RNA Duplexes Using 2-Amino-6-Vinylpurine and Their Application for Effective Inhibition of miRNA Function. Current Protocols. 2022. 2. 3
  • Ruriko Fukushima, Tetsuya Suzuki, Yasuo Komatsu, Hiroyuki Kamiya. Biased distribution of action-at-a-distance mutations by 8-oxo-7,8-dihydroguanine. Mutation research. 2022. 825. 111794-111794
  • Yu Hirano, Yasuo Komatsu. Promotion of cytoplasmic localization of oligonucleotides by connecting cross-linked duplexes. RSC Advances. 2022
  • Sho Okumura, Yu Hirano, Yasuo Komatsu. Stable duplex-linked antisense targeting miR-148a inhibits breast cancer cell proliferation. Scientific Reports. 2021. 11. 1
  • Ahmed Mostafa Abdelhady, Yu Hirano, Kazumitsu Onizuka, Hidenori Okamura, Yasuo Komatsu, Fumi Nagatsugi. Synthesis of crosslinked 2′-OMe RNA duplexes and their application for effective inhibition of miRNA function. Bioorganic & Medicinal Chemistry Letters. 2021. 48. 128257-128257
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MISC (59)：
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Patents (19)：
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Books (4)：
  • Environmentally Responsive and Bright Fluorescent Probes Possessing Dansyl-modified Oligonucleotides under Hybridization of DNA and RNA.
    Springer 2015 ISBN:9783319173054
  • Hydroxylamine, Oxime and Hydroxamic Acid Derivatives of Nucleic Acids.
    WILEY 2010 ISBN:9780470682531
  • Regulation of ribozyme activity by oligonucleotides
    Humana Press 2004 ISBN:9781592597468
  • Chemical RNA synthesis (Including RNA with unusual constituents).
    Oxford 1999 ISBN:9780080431581
Professional career (1)：
  • 博士(薬学)
Work history (11)：
  • 2022/04 - 現在 National Institute of Advanced Industrial Science and Technology
  • 2015/04 - 現在 Hokkaido University
  • 2020/04 - 2022/03 National Institute of Advanced Industrial Science and Technology
  • 2019/04 - 2020/03 National Institute of Advanced Industrial Science and Technology
  • 2018/04 - 2019/03 National Institute of Advanced Industrial Science and Technology
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Awards (1)：
  • 2002/03 - 日本薬学会 薬学会奨励賞 RNA酵素の構造活性相関に関する研究と新規RNA酵素の開発
Association Membership(s) (4)：
RNA学会 ,  日本核酸化学会 ,  日本核酸医薬学会 ,  日本薬学会
※ Researcher’s information displayed in J-GLOBAL is based on the information registered in researchmap. For details, see here.

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