Rchr

J-GLOBAL ID：200901088002313998 Update date: Nov. 05, 2024

Mizukami Yoichi

ミズカミヨウイチ | Mizukami Yoichi

Affiliation and department：
Job title： Professor
Other affiliations (3)：

Yamaguchi University Science Research Center, Institute of Gene Research Professor
Yamaguchi University Science Research Center, Institute of Gene Research Professor
Yamaguchi University Science Research Center, Institute of Gene Research Professor

Homepage URL (1)： http://gene.yamaguchi-u.ac.jp/

Research field (2)： Physiology , Tumor biology

Research keywords (1)： Physiology in General,Biochemistry

Research theme for competitive and other funds (47)：

2024 - 2028 Analysis of genomic DNA in aging heart
2024 - 2027 アルドケト還元酵素に着目した卵巣若返り法に関する基盤研究
2024 - 2027 乳がん組織における網羅的な微生物/宿主細胞の検出によるがん微小環境の解明
2022 - 2025 ヒト全ゲノム解析を用いて染色体に挿入された老化ウイルスを解明する
2022 - 2025 ALK陽性未分化大細胞リンパ腫におけるALK阻害剤耐性の機序解明と新規治療の開発

2022 - 2025 血糖コントロールを重視したAkt2活性化による新たな脊髄保護法の開発

2021 - 2024 Whlole genome analysis in exosome from dilated cardiomyopathy occurred by aging

2021 - 2024 GONAD法を用いた乳がんゲノム複数変異導入モデルの作成及びシングルセル発現解析

2020 - 2024 流域におけるノロウイルスの動態把握と流行予測

2019 - 2023 微小管ダイナミクスに関わるKIF20Bの機能解析と乳癌幹細胞の新規治療への展開

2018 - 2023 Identification of infertile genes in aging mice using genome editing method

2019 - 2022 Spinal cord protection using glucagon-like peptide-1 receptor agonists

2018 - 2021 Elucidation of Breast Cancer Endocrine Therapy Resistance by Single Cell Analysis using Blood Circulating Tumor Cells

2016 - 2019 A new strategy for spinal cord protection focusing on synaptic and extrasynaptic NMDA receptors

2015 - 2019 Elucidation of cardiomyopathy caused by gene mutations induced environmental stresses -exhaustive mutation analysis and genome editing-genome

2015 - 2018 Development of the detection method for animal cysticercosis and the investigation of the genetic factors for host specificity

2015 - 2018 Development of activation method for LH and FSH secretion in dairy cows based on pure bovine gonadotroph model

2013 - 2016 Spinal cord protection by the activation of neuroglobin

2012 - 2016 Identification of master molecules in signal transduction of canceled cells using TAT protein

2013 - 2015 Identification of master regulator on TNBC malignant using TAT protein system

2012 - 2014 Elucidation of estrogen signal pathwey with cell specific RNAi collection

2009 - 2011 High throughput screening for G protein-coupled receptor(s) activated in response to estrogen by RNAi collection

2008 - 2010 Time and spatial regulation of the embryo implantation at fetomaternal interface ; the resolution of habitual and spontaneous abortion.

2009 - 2009 新規女性ホルモン受容体をモデルにした未知1塩基変異の高速検出方法の開発

2008 - 2008 高気圧酸素による虚血耐性誘導を応用した脳血管障害の新規予防・治療戦略の開発

2007 - 2008 Analysis of the CD45-Lyn-mediated signaling pathways in theIL-6-induced myeloma cell proliferation

2007 - 2007 細胞膜女性ホルモン受容体を標的とした治療薬開発のための組換え動物の作製

2006 - 2007 A novelestrogen receptor in plasma membrane

2005 - 2007 Mechanism for ischemic crosstoleance in central nervous system and its therapeutic application

2005 - 2006 Analysis of the IL-6-mediated intracellular signaling molecules in myeloma cell growth

2004 - 2005 Screening of a ligand for hypoxia-induced receptor by negative selection method

2001 - 2002 Identification of activating factors for signal transduction released during ischemia in heart

2000 - 2001 血管の緊張異常を阻害する新規の細胞膜脂質成分の同定と細胞内情報伝達機構の解明

1999 - 2001 Molecular and cellular physiological studies on the intracellular signal transduction causing abnormal vascular contraction

2000 - 2000 新規の生合成経路を有する内皮由来血管弛緩物質の同定および情報伝達機構の解明

1999 - 2000 アポトーシスを制御するシグナル伝達経路の解明-細胞生存因子として機能する新規生理活性脂質の同定-

1999 - 1999 血管の異常収縮を抑制する未知の膜脂質成分の同定および情報伝達機構の解明

1998 - 1999 FORENSIC PATHOLOGICAL STUDY ON PROTEINS AND GENES INDUCED BY STRESS OR ISCHEMIA

1997 - 1998 心筋虚血及び各種ショックにおける一酸化窒素の関与に関する法医分子病理学的研究

1996 - 1996 早期虚血心筋における細胞内情報伝達系の活性化と障害誘導機序に関する研究

1996 - 1996 虚血再灌流時におけるMAPキナーゼの活性化機構

1995 - 1995 プロテインキナーゼとカルパインを介する細胞骨格蛋白の変化の心筋梗塞化における役割

酸化ストレスにおけるシグナル伝達

心臓におけるシグナル伝達

オーファン受容体のリガンドスクリーニング

Signal Trensduction in Heart

Screening of orphan receptors

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Papers (137)：

Kazuhiro Onuma, Kenji Watanabe, Keishiro Isayama, Sayaka Ogi, Yasunori Tokunaga, Yoichi Mizukami. Bardoxolone methyl prevents metabolic dysfunction-associated steatohepatitis by inhibiting macrophage infiltration. British Journal of Pharmacology. 2024
Minori Abe, Manami Masuda, Yoichi Mizukami, Shintaro Inoue, Yukiko Mizutani. Epidermal keratinocytes regulate hyaluronan metabolism via extracellularly secreted hyaluronidase 1 and hyaluronan synthase 3. The Journal of biological chemistry. 2024. 107449-107449
Jun Nishikawa, Tomohiro Fujii, Soichiro Fukuda, Shoma Yoneda, Yuta Tamura, Yuki Shimizu, Akie Yanai, Yuki Kobayashi, Koji Harada, Keisuke Kawasaki, et al. Far-ultraviolet irradiation at 222 nm destroys and sterilizes the biofilms formed by periodontitis pathogens. Journal of microbiology, immunology, and infection = Wei mian yu gan ran za zhi. 2024
Taiki Kato, Masashi Sakurai, Kenji Watanabe, Yoichi Mizukami, Takayuki Nakagawa, Kenji Baba, Takuya Mizuno, Masaya Igase. Identification of hypoxia-induced metabolism-associated genes in canine tumours. Veterinary and comparative oncology. 2024
Kenshi Yoshimura, Wei Mengyan, Shinichiro Kume, Tatsuki Kurokawa, Shinji Miyamoto, Yoichi Mizukami, Katsushige Ono. Detection and identification of factors in the atrium responsible for blood pressure regulation in patients with hypertension. Heart and vessels. 2024. 39. 5. 464-474

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MISC (123)：

加藤大樹, 櫻井優, 渡邉健司, 水上洋一, 中川貴之, 水野拓也, 伊賀瀬雅也. Identification of hypoxia-induced metabolism-associated genes in canine tumors. 日本癌学会学術総会抄録集(Web). 2023. 82nd
渡邉健司, 山本滋, 前田訓子, 坂口修一, 八木美佳子, 康東天, 岡正朗, 永野浩昭, 水上洋一. 乳癌患者から検出したミトコンドリアDNA体細胞変異発現細胞の全転写産物解析. 日本分子生物学会年会プログラム・要旨集(Web). 2020. 43rd
太田康晴, 田口昭彦, 松村卓郎, 福田尚文, 山本薫, 柳井章江, 秋山優, 藤本留理子, 神吉けい太, 汐田剛史, et al. 次世代に向けた体質医学研究体内時計と代謝制御機構. 日本体質医学会雑誌. 2019. 81. 3. 202-202
太田康晴, 松村卓郎, 田口昭彦, 福田尚文, 山本薫, 柳井章江, 秋山優, 藤本留理子, 神吉けい太, 汐田剛史, et al. 出力系時計遺伝子DBP,E4BP4を介した肝臓における脂質代謝制御機構. 糖尿病. 2019. 62. Suppl.1. S-197
太田康晴, 松村卓郎, 田口昭彦, 福田尚文, 山本薫, 柳井章江, 秋山優, 藤本留理子, 神吉けい太, 汐田剛史, et al. 出力系時計遺伝子DBP,E4BP4を介した肝臓における脂質代謝制御機構. 糖尿病. 2019. 62. Suppl.1. S-197

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Patents (12)：

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Books (5)：

Molecular Mechanisms of Heart diseases
Research Signport 2005
Molecular Mechanisms of Heart diseases
Research Signport 2005
Recent Research Development in Biochmistry
Reseach Signpost 2003
The role of phosphoinositide 3-kinase in ischemiac heart
Recent Research Development in Biochmistry 2003
Mitogen-activeted Protein Kinase Pathway in Ischemic Heart
Recent Research Development in Biological Chemistry 2002

Lectures and oral presentations (17)：

Lipopolysaccharide promotes NADPH oxidase-mediated production of 4-hydroxynonenal that modifies fragmented GRP78 in rat liver
(Biomarkers of Oxidative Stress in Health and Diseases HSSRC/AIST-NIEHS/NIH Joint International Symposium, Abstract 2008)
4重極タンデム質量分析計によるラット脳内発現タンパク質のプロテオーム解析
(第30回日本分子生物学会、第80回日本生化学会合同大会講演要旨集 2007)
心肺停止蘇生後患者における脳脊髄液の病態プロテオーム解析:神経学的予後予測マーカー群の同定
(第30回日本分子生物学会、第80回日本生化学会合同大会講演要旨集 2007)
低酸素刺激によって胎児心臓由来株化細胞H9c2細胞から放出される分泌蛋白質のプロテオミクス解析
(第30回日本分子生物学会、第80回日本生化学会合同大会講演要旨集 2007)
PROTEOMIC ANALYSIS OF CEREBROSPINAL FLUID FROM PATIENTS WITH CARDIOPULMONARY RESUSCITATION
(HUPO 6th annual world congress 2007)

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Works (4)：

Activation mechanism of nuclear MAPK
2000 - 2000
核内MAPKの活性化機構
2000 - 2000
Activation of JNK in ischemic heart
1997 - 1997
心筋虚血におけるJNKの活性化
1997 - 1997

Work history (1)：

2010/05/18 - 現在 YAMAGUCHI UNIVERSITY Organization for Research Initiatives Professor

Awards (2)：

2001 - 山口医学会中村賞
1999 - 日本心臓財団優秀賞

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