Miyano Masashi

Research field (7)： Structural biochemistry , Genomics , Pharmaceuticals - chemistry and drug development , Molecular biology , Ecology and environmental science , Biophysics , Morphology, anatomy

Research theme for competitive and other funds (2)：

- 現在 Structural Biology for Drug Discovery
2013 - 2018 細胞膜の異質界面における分子理解と新機能創成基盤の形成

Papers (35)：

Tetsuya Hori, Toshiaki Okuno, Kunio Hirata, Keitaro Yamashita, Yoshiaki Kawano, Masaki Yamamoto, Masakatsu Hato, Motonao Nakamura, Takao Shimizu, Takehiko Yokomizo, et al. Na+-mimicking ligands stabilize the inactive state of leukotriene B4 receptor BLT1. Nature chemical biology. 2018. 14. 3. 262-269
Kawakami, Yuki, Kinoshita, Mai, Mori, Yoshiko, Okochi, Shuji, Hirano, Shiori, Shimoda, Ichika, Kanzaki, Keita, Suzuki-Yamamoto, Toshiko, Kimoto, Masumi, Sugahara, Mitsuaki. The Y54(L)W mutation of anti-leukotriene C₄ single-chain antibody increases affinity to leukotriene E₄. J. Biochem. 2017. 161. 79-86
Ago H, Adachi H, Umena Y, Tashiro T, Kawakami K, Kamiya N, Tian L, Han G, Kuang T, Liu Z, et al. Novel Features of Eukaryotic Photosystem II Revealed by Its Crystal Structure Analysis from a Red Alga. J. Biol. Chem. 2016. 291. 5676-5687
Advanced Structure-based Drug Design. 2015. 66. 12. 933-940
Hori, T, Nakamura, M, Yokomizo, Y, Shimizu, T, Miyano, M. The leukotriene B₄ receptor BLT1 is stabilized by transmembrane helix capping mutations. Biochemistry and Biophysics Reports. 2015. 4. 243-249

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Patents (3)：

結晶評価装置
プロスタグランジンD合成酵素の3次元立体構造及びその使用
タンパク質の結晶化方法及び装置

Books (4)：

日本の結晶学(II) MAPEGとしてのロイコトリエンC4合成酵素
日本結晶学会 2014
放射光が解き明かす驚異のナノ世界
ブルーバックス講談社 2011
"Biochemical and structural characteristics of hematopoietic prostaglanding D synthase: From evolutionary analysis to drug design." In "Functional and Structural Biology on the Lipo-network" Ed. By Kosuke Morikawa and Shin-ichi Tate
Transworld Research Network, Kerala, India 2006
RIKEN/BBSRC Joint Symposium Japan-UK Membrane Protein Structure Biology. Proceeding
2003

Lectures and oral presentations (32)：

青山学院大学化学・生命科学教育における複合的ICT利用の実践
(平成30年度教育改革ICT戦略大会 2018)
Structure basis of Leukotriene C4 Synthase and its isophtalate inhibitors.
(IUCr2014 2014)
カルバペネム耐性β-ラクタマーゼOXA-58の高分解能結晶構造解析
(日本結晶学会年会 2014)
カルバペネム耐性β-ラクタマーゼ OXA-58の結晶化
(日本結晶学会 2013)
創薬標的の膜タンパク質立体構造解析
(帝人ファーマ(株) 2012)

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Education (2)：

1976 - 1978 Tohoku University Graduate School, Division of Natural Science
1972 - 1976 Tohoku University Faculty of Science

Professional career (3)：

理学士 (東北大学)
理学修士 (東北大学)
理学博士 (東北大学)

Work history (12)：

2014/04 - 現在 RIKEN
2011/04/01 - 2022/03/31 College of Science and Engineering College of Science and Engineering Department of Chemistry and Biological Science Professor
2003/04 - 2012/03 University of Tokyo Part-time researcher for university or other academic organization
2000/04 - 2011/03 RIKEN Manager(Dean)
2006/09 - 2006/09 Nagoya University, Graduate School of Bioagricultual Sciences

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Association Membership(s) (3)：

日本生化学会 , 日本結晶学会 , 日本生物物理学会

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