HIROSHI SHIBATA

Affiliation and department：

Research field (1)： Metabolism and endocrinology

Research keywords (11)： insulin action, glucose transport, adipocyte, vesicle traffic, post-translational modification , post-translational modification , vesicle traffic , adipocyte , glucose transport , insulin action , 翻訳後修飾 , 小胞輸送 , 脂肪細胞 , グルコーストランスポート , インスリン作用

Research theme for competitive and other funds (4)：

subcellular membrane taffic
Mechanism of insulin action
細胞内小胞輸送機構
インシュリン作用機構

Papers (111)：

Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M. Rasenick, Takeshi Inagaki, Hiroshi Shibata. T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells. PLOS ONE. 2017. 12. 5
Nakagawa, Yuko, Ohtsu, Yoshiaki, Nagasawa, Masahiro, Shibata, Hiroshi, Kojima, Itaru. Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3. ENDOCRINE JOURNAL. 2014. 61. 2
Jinhui Ma, Yuko Nakagawa, Itaru Kojima, Hiroshi Shibata. Prolonged Insulin Stimulation Down-regulates GLUT4 through Oxidative Stress-mediated Retromer Inhibition by a Protein Kinase CK2-dependent Mechanism in 3T3-L1 Adipocytes. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 1. 133-142
Sasaki, Tsutomu, Shimpuku, Mayumi, Kitazumi, Tomoya, Hiraga, Haruna, Nakagawa, Yuko, Shibata, Hiroshi, Okamatsu-Ogura, Yuko, Kikuchi, Osamu, Kim, Hye-jin, Fujita, Yuki, et al. Miglitol prevents diet-induced obesity by stimulating brown adipose tissue and energy expenditure independent of preventing the digestion of carbohydrates. ENDOCRINE JOURNAL. 2013. 60. 10
Yosuke Masubuchi, Yuko Nakagawa, Jinhui Ma, Tsutomu Sasaki, Tadahiro Kitamura, Yoritsuna Yamamoto, Hitoshi Kurose, Itaru Kojima, Hiroshi Shibata. A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells. PLoS ONE. 2013. 8. 1

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MISC (190)：

Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M. Rasenick, Takeshi Inagaki, Hiroshi Shibata. T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells. PLOS ONE. 2017. 12. 5. e0176841
Yosuke Masubuchi, Yuko Nakagawa, Johan Medina, Masahiro Nagasawa, Itaru Kojima, Mark M. Rasenick, Takeshi Inagaki, Hiroshi Shibata. T1R3 homomeric sweet taste receptor regulates adipogenesis through G alpha s-mediated microtubules disassembly and Rho activation in 3T3-L1 cells. PLOS ONE. 2017. 12. 5. e0176841
Yuko Nakagawa, Yoshiaki Ohtsu, Masahiro Nagasawa, Hiroshi Shibata, Itaru Kojima. Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3. ENDOCRINE JOURNAL. 2014. 61. 2. 119-131
Yuko Nakagawa, Yoshiaki Ohtsu, Masahiro Nagasawa, Hiroshi Shibata, Itaru Kojima. Glucose promotes its own metabolism by acting on the cell-surface glucose-sensing receptor T1R3. ENDOCRINE JOURNAL. 2014. 61. 2. 119-131
Jinhui Ma, Yuko Nakagawa, Itaru Kojima, Hiroshi Shibata. Prolonged Insulin Stimulation Down-regulates GLUT4 through Oxidative Stress-mediated Retromer Inhibition by a Protein Kinase CK2-dependent Mechanism in 3T3-L1 Adipocytes. JOURNAL OF BIOLOGICAL CHEMISTRY. 2014. 289. 1. 133-142

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Patents (1)：

糖代謝促進剤並びに肥満及び糖尿病治療薬のスクリーニング方法

Books (5)：

Principles and Practice 内分泌・代謝-医学生・レジデントのための必修エッセンス-
文光堂 2011
商工まえばし
前橋商工会議所 2009
ブックレット群馬大学(1):群馬に多い病気~生活習慣病を知り、克服する
上毛新聞社 2007
分子糖尿病学の進歩-基礎から臨床まで-1995
金原出版 1995
BIOSCIENCE SERIES カルシウムのシグナル伝達機構
中外医学社 1993

Lectures and oral presentations (52)：

Sweet Taste Receptor Regulates Adipogenesis Through Gs-Mediated Microtubule Disassembly and Rho Activation in 3T3-L1 Cells
(73rd Scientific Sessions of American Diabetes Association 2013)
Sweet Taste Receptor Regulates Adipogenesis Through Gs-Mediated Microtubule Disassembly and Rho Activation in 3T3-L1 Cells
(73rd Scientific Sessions of American Diabetes Association 2013)
甘味刺激によるGs活性化は微小管脱重合とRho活性化を介して脂肪分化を抑制する
(第56回日本糖尿病学会年次学術集会 2013)
A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells
(72nd Scientific Sessions of American Diabetes Association 2012)
A Novel Regulatory Function of Sweet Taste-Sensing Receptor in Adipogenic Differentiation of 3T3-L1 Cells
(72nd Scientific Sessions of American Diabetes Association 2012)

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Education (2)：

- 1980 The University of Tokyo Faculty of Medicine
- 1980 The University of Tokyo Faculty of Medicine

Professional career (1)：

(BLANK) (Gunma University)

Work history (9)：

2007 - -群馬大学准教授
1995 - 2006 Associate Professor, Department of Cell Biology, Gunma University
1995 - 2006 Gunma University
1993 - 1995 Lecturer, Department of Cell Biology, Gunma University
1993 - 1995 Gunma University

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Committee career (6)：

米国細胞生物学会 active member
米国糖尿病学会 acive member
日本生理学会評議員
米国糖尿病学会 acive member
米国細胞生物学会 active member

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Association Membership(s) (6)：

The Molecular Biology Society of Japan , 米国細胞生物学会 , 日本糖尿病学会 , 米国糖尿病学会 , 日本生理学会 , 日本生化学会

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