2013 - 2018 Development of methods to regulate abnormality of insulin-like activity by modulation of function of insulin receptor substrates-associated complex
2012 - 2016 Analysis of gene expression regulation through precise reconstitution of ‘epi-nucleosome'
2012 - 2015 Regulation of nucleosome through a chromatin-demodifying enzyme
2010 - 2012 Analysis of a transcriptional regulatory mechanism by histone/p53 demethylase complex
2008 - 2011 Structure-based drug development targeting modification/recognition pockets of epigenetic information
2007 - 2009 Complex formation and structural/functional analysis of chromatin-associated factors
Keiko Shinjo, Takashi Umehara, Hideaki Niwa, Shin Sato, Keisuke Katsushima, Shinya Sato, Xingxing Wang, Yoshiteru Murofushi, Miho M. Suzuki, Hiroo Koyama, et al. Novel pharmacologic inhibition of lysine-specific demethylase 1 as a potential therapeutic for glioblastoma. Cancer Gene Therapy. 2024
Yosuke Nishigaya, Shohei Takase, Tatsunobu Sumiya, Tomohiro Sato, Hideaki Niwa, Shin Sato, Akiko Nakata, Seiji Matsuoka, Yuki Maemoto, Noriaki Hashimoto, et al. Structure-based development of novel substrate-type G9a inhibitors as epigenetic modulators for sickle cell disease treatment. Bioorganic & Medicinal Chemistry Letters. 2024. 110. 129856-129856
Shinsuke Ito, Takashi Umehara, Haruhiko Koseki. Polycomb-mediated histone modifications and gene regulation. Biochemical Society Transactions. 2024. 52. 1. 151-161
Akari Miwa, Masatoshi Wakamori, Tetsuro Ariyoshi, Yasushi Okada, Mikako Shirouzu, Takashi Umehara, Koki Kamiya. Efficiency of transcription and translation of cell-free protein synthesis systems in cell-sized lipid vesicles with changing lipid composition determined by fluorescence measurements. Scientific Reports. 2024. 14. 1. 2852-2852
1994 - 1999 The University of Tokyo Graduate School of Pharmaceutical Sciences
1990 - 1994 The University of Tokyo Faculty of Pharmaceutical Sciences
Professional career (1)：
Ph.D. (The University of Tokyo)
Work history (8)：
2023 - 現在 RIKEN Senior Scientist
2019 - 2023 RIKEN Team Leader
2013 - 2019 RIKEN Unit Leader
2007 - 2013 RIKEN Senior Scientist
2005 - 2007 RIKEN Research Scientist
2003 - 2005 RIKEN Research Associate
2001 - 2003 Japan Science and Technology Agency Research Manager
1999 - 2001 Japan Science and Technology Agency Research Fellow
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Committee career (2)：
2022 - 現在 Epigenomes Editorial Board Member
2021 - 現在 ACS Bio & Med Chem Au Editorial Advisory Board Member
Awards (1)：
2011 - The Japanese Society for Epigenetics Young Investigator Award
Association Membership(s) (6)：
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
, PROTEIN SCIENCE SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR EPIGENETICS
, THE PHARMACEUTICAL SOCIETY OF JAPAN
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, The Japanese Biochemical Society
