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J-GLOBAL ID：201301095145026085   Update date: Sep. 28, 2024

Nagasawa Hideko

ナガサワ ヒデコ | Nagasawa Hideko
Affiliation and department：
Gifu Pharmaceutical University Faculty of Pharmaceutical Science

About Gifu Pharmaceutical University Faculty of Pharmaceutical Science


Job title： Professor
Homepage URL  (2)： https://yakka-gifu-pu.jp/ ,  https://www.researchgate.net/profile/Hideko_Nagasawa
Research field  (6)： Chemical biology ,  Bioorganic chemistry ,  Structural/physical organic chemistry ,  Tumor diagnostics and therapeutics ,  Pharmaceuticals - chemistry and drug development ,  Pharmaceuticals - chemistry and drug development
Research keywords  (35)： antitumor drug ,  cyclic peptide ,  ferroptosis ,  fluorescent probe ,  oxidative stress ,  hypoxia ,  tumor microenvironment ,  Molecular Design ,  VEGF ,  がん ,  HIF-1 ,  anti-angiogenesis ,  structure-activity relationship ,  中性子捕捉療法(BNCT) ,  ニトロ芳香族化合物 ,  環状イミド誘導体 ,  インテグリン ,  RGD ,  ボロンキャリア ,  HIFL-1α ,  けいれん ,  柴胡桂枝湯加芍薬 ,  hypoxic cytotoxin ,  ペンチレンテトラゾール ,  カルシウム流 ,  boron neutron capture therapy ,  HIF-1α ,  新生血管 ,  医薬品分子設計 ,  アポトーシス ,  ボロンクラスタ ,  てんかん ,  インテグリン受容体 ,  血管新生阻害剤 ,  differential hybridization
Research theme for competitive and other funds  (26)：
  • 2019 - 2024 タンパク質の非平衡状態構造解析を可能にするケミカル光制御法の開発
  • 2019 - 2023 Development of novel boron carrier utilizing amino acid transporters specific for glutamine addiction of cancer cells
  • 2019 - 2022 Interrelationship analysis of the characteristics of quiescent tumor cells with tumor heterogeneity and cancer stem cell nature, referring to application to cancer therapy
  • 2016 - 2019 Development of tumor-selective drug based on synthetic lethal strategy by overcoming oxidative stress tolerance of cancer
  • 2015 - 2019 Analysis of neoplastic cell-specific fatal effects with reactive oxygen species abnormality derived from compound from plant species, piperlongumine
Show all
Papers (194)：
  • Aomi Muramatsu, Shinsuke Nakamura, Tasuku Hirayama, Hideko Nagasawa, Akihiro Ohira, Takashi Kitaoka, Hideaki Hara, Masamitsu Shimazawa. Both hemoglobin and hemin cause damage to retinal pigment epithelium through the iron ion accumulation. Journal of Pharmacological Sciences. 2024. 155. 2. 44-51
  • 辻 大輔, 平山 祐, 河合 寛太, 永澤 秀子, 赤木 玲子. フェロトーシスに対する細胞内遊離ヘム変動の影響. 日本生化学会大会プログラム・講演要旨集. 2023. 96回. [1P-311]
  • Tomohiro Suzuki, Tetsuro Komatsu, Hiroshi Shibata, Akiko Tanioka, Diana Vargas, Reika Kawabata-Iwakawa, Fumihito Miura, Shinnosuke Masuda, Mayuko Hayashi, Kyoko Tanimura-Inagaki, et al. Crucial role of iron in epigenetic rewriting during adipocyte differentiation mediated by JMJD1A and TET2 activity. Nucleic acids research. 2023. 51. 12. 6120-6142
  • Takumi Kariya, Hayato Hasegawa, Taro Udagawa, Yusaku Inada, Kyoko Nishiyama, Mieko Tsuji, Tasuku Hirayama, Tatsuo Suzutani, Naoki Kato, Shingo Nagano, et al. Elucidation of the stereocontrol mechanisms of the chemical and biosynthetic intramolecular Diels-Alder cycloaddition for the formation of bioactive decalins. RSC Advances. 2023. 13. 40. 27828-27838
  • Mieko Tsuji, Haruno Taira, Taro Udagawa, Tatsuya Aoki, Tasuku Hirayama, Hideko Nagasawa. Synthesis and photochemical properties of caged peroxides for photocontrol of cellular oxidative stress. Chemical Communications. 2023
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MISC (95)：
  • 新津明穂, 山本凌大, 真田悠生, 渡邉翼, 増永慎一郎, 増永慎一郎, 辻美恵子, 平山佑, 永澤秀子. Development of a novel boron carrier for BNCT exploiting a tumor-specific amino acid transport system. 日本薬学会年会要旨集(Web). 2023. 143rd
  • 垣内亮, 平山祐, 柳沢大治郎, 遠山育夫, 辻美恵子, 永澤秀子. Development of Fe(II)-detective 19F-MRI probe utilizing chemical shift-switch. 日本薬学会年会要旨集(Web). 2021. 141st
  • 増永慎一郎, 真田悠生, 永澤秀子, 原田浩, 平山亮一, 笠岡敏, 長崎健, 宇都義浩, 安井博宣, 益谷美都子, et al. Analyzing tumor microenvironment and exploiting its characteristics in search of optimizing cancer therapy including neutron capture therapy. KURNS-EKR (Web). 2021. 10
  • 松下明香里, 辻美恵子, 真田悠生, 平山祐, 増永慎一郎, 永澤秀子. Development of new boron carriers for BNCT targeting amino acid transporters. KURNS-EKR (Web). 2021. 10
  • 永澤秀子. Cancer drug development targeting hypoxia and nutritional deficiencies of the tumor microenvironment. 実験医学. 2021. 39. 12
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Patents (9)：
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Books (2)：
  • がん微小環境に1細胞レベルで挑む : 技術革新で見えてきた腫瘍内の細胞と免疫応答の多様性、がん悪性化・治療抵抗性の鍵
    羊土社 2021 ISBN:9784758103961
  • 酸化ストレスの医学
    診断と治療社 2014 ISBN:9784787821188
Education (2)：
  • 1984 - 1988 Kyoto University Graduate School of Pharmaceutical Sciences
  • 1979 - 1983 Gifu Pharmaceutical University
Professional career (1)：
  • ph. D. (Kyoto University)
Work history (5)：
  • 2006/04 - 現在 Gifu Pharmaceutical University Professor
  • 2001/04 - 2006/03 The University of Tokushima Faculty of Engineering Associate Professor
  • 2004/09 - 2005/09 Johns Hopkins School of Medicine Visiting Associate Professor
  • 1997/04 - 2001/03 The Tokushima University Faculty of Engineering Associate Professor
  • 1988/04 - 1997/03 Keio University School of Medicine Assistant Professor
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