Ai Takano

タカノアイ | Ai Takano

Affiliation and department：
Homepage URL (1)： http://organoidmed.org

Research field (1)： Tumor biology

Research keywords (4)： organoid , cancer , 大腸癌 , stemcell

Research theme for competitive and other funds (6)：

2017 - 2020 Drug discovery screening targeting gastrointestinal cancer stem cells
2015 - 2017 High- throughput screening for personalized medicine targeting gastrointestinal cancer stem cell.
2013 - 2015 High-throughput screening for drug discovery targeting gastrointestinal cancer stem cell.
2013 - 2015 消化器がん幹細胞を標的としたHigh throughput スクリーニング創薬
2012 - 2014 Identification of human colorectal cancer stem cells.

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Papers (14)：

Hiroki Tamagawa, Masayuki Fujii, Kazuhiro Togasaki, Takashi Seino, Shintaro Kawasaki, Ai Takano, Kohta Toshimitsu, Sirirat Takahashi, Yuki Ohta, Mami Matano, et al. Wnt-deficient and hypoxic environment orchestrates squamous reprogramming of human pancreatic ductal adenocarcinoma. Nature cell biology. 2024. 26. 10. 1759-1772
Yuki Ohta, Masayuki Fujii, Sirirat Takahashi, Ai Takano, Kosaku Nanki, Mami Matano, Hikaru Hanyu, Megumu Saito, Mariko Shimokawa, Shingo Nishikori, et al. Cell-matrix interface regulates dormancy in human colon cancer stem cells. Nature. 2022. 608. 7924. 784-794
Keiko Ishikawa, Shinya Sugimoto, Mayumi Oda, Masayuki Fujii, Sirirat Takahashi, Yuki Ohta, Ai Takano, Kazuhiro Ishimaru, Mami Matano, Kosuke Yoshida, et al. Identification of Quiescent LGR5+ Stem Cells in the Human Colon. Gastroenterology. 2022
Kohta Toshimitsu, Ai Takano, Masayuki Fujii, Kazuhiro Togasaki, Mami Matano, Sirirat Takahashi, Takanori Kanai, Toshiro Sato. Organoid screening reveals epigenetic vulnerabilities in human colorectal cancer. Nature chemical biology. 2022
Kenta Kawasaki, Kohta Toshimitsu, Mami Matano, Masashi Fujita, Masayuki Fujii, Kazuhiro Togasaki, Toshiki Ebisudani, Mariko Shimokawa, Ai Takano, Sirirat Takahashi, et al. An Organoid Biobank of Neuroendocrine Neoplasms Enables Genotype-Phenotype Mapping. Cell. 2020. 183. 5. 1420-1435

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MISC (3)：

Yu Katsuyama, Ai Takano, Naoya Ryoyama, Hideaki Imai, Noriko Osumi, Masahiko Hibi, Toshio Terashima. Essential function of Sbno1 in Notch signal suppression during cortical neuron differentiation. NEUROSCIENCE RESEARCH. 2011. 71. E126-E126
Hideaki Imai, Ai Takano, Naoya Ryoyama, Kenji Sakimura, Kozo Sugioka, Toshio Terashima, Yu Katsuyama. Histological and behavioral analysis of telencephalon-spesific Dab1-deficient mouse. NEUROSCIENCE RESEARCH. 2010. 68. E170-E171
Ai Takano, Riyo Zochi, Masahiko Hibi, Toshio Terashima, Yu Katsuyama. The role of Strawberry notch family genes in the central nervous system development of zebrafish. NEUROSCIENCE RESEARCH. 2007. 58. S82-S82

Education (2)：

Professional career (1)：

Work history (1)：

2012/04 - 現在 Keio University School of Medicine The Sakaguchi Laboratory - Department of Organoid Medicine

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