Begum Nasim

Affiliation and department：
Job title： ( Associate Professor )

Research field (2)： Immunology , Molecular biology

Research keywords (3)： Antibody Class Switch Recombination , Epigenomic Regulation , Genomic Instability

Papers (53)：

Santosh K Gothwal, Ahmed M Refaat, Mikiyo Nakata, Andre Stanlie, Tasuku Honjo, Nasim A Begum. BRD2 promotes antibody class switch recombination by facilitating DNA repair in collaboration with NIPBL. Nucleic Acids Research. 2024. 52. 8. 4422-4439
Ahmed M. Refaat, Mikiyo Nakata, Afzal Husain, Hidetaka Kosako, Tasuku Honjo, Nasim A. Begum. HNRNPU facilitates antibody class-switch recombination through C-NHEJ promotion and R-loop suppression. Cell Reports. 2023. 42. 3. 112284-112284
Nasim A Begum, Farazul Haque, Andre Stanlie, Afzal Husain, Samiran Mondal, Mikiyo Nakata, Takako Taniguchi, Hisaaki Taniguchi, Tasuku Honjo. Phf5a regulates DNA repair in class switch recombination via p400 and histone H2A variant deposition. The EMBO journal. 2021. 40. 12. e106393
Afzal Husain, Jianliang Xu, Hodaka Fujii, Mikiyo Nakata, Maki Kobayashi, Ji-Yang Wang, Jan Rehwinkel, Tasuku Honjo, Nasim A Begum. SAMHD 1-mediated dNTP degradation is required for efficient DNA repair during antibody class switch recombination. The EMBO Journal. 2020. 39. 15
Ziwei Yin, Maki Kobayashi, Wenjun Hu, Koichi Higashi, Nasim A. Begum, Ken Kurokawa, Tasuku Honjo. RNA-binding motifs of hnRNP K are critical for induction of antibody diversification by activation-induced cytidine deaminase. Proceedings of the National Academy of Sciences. 2020. 117. 21. 11624-11635

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Education (4)：

Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan, Postdoctoral Training (Innate Immunity; Adjuvant Therapy; Infection)
University of Massachusetts Medical Center, Worcester, USA; Postdoctoral Training (Cancer Biology; Gene Regulation; Prognostic Marker)
Indian Institute of Chemical Biology and Jadavpur University, Calcutta, India ( Ph D in Biochemistry )
Visva Bharati University, West Bengal, India ( B Sc & M Sc in Life Science )

Professional career (1)：

Work history (3)：

Kyoto University, Graduate School of Medicine, Department of Immunology and Genomic Medicine
Kyoto University,Graduate School of Medicine, Department of Immunology and Genomic Medicine
Indian Institute of Chemical Biology, Calcutta, India Department of Biophysics

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