Nishimasu Hiroshi

Affiliation and department：

Research field (1)： Structural biochemistry

Research keywords (4)：クライオ電子顕微鏡 , CRISPR , タンパク質 , RNA

Research theme for competitive and other funds (13)：

2021 - 2026 Structural Analysis of Non Domain Biopolymer
2022 - 2025 Structural and functional analysis of diverse RNA helicases involved in innate immunity
2021 - 2024 デジタル検出技術を基盤としたウイルスの新規感染診断法の開発
2020 - 2023 CRISPRを用いた新規ゲノム改変技術の開発
2019 - 2022 Genome editing-based gene therapy for primary immunodeficiency caused by dominant gain-of-function mutations.

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Papers (94)：

Kaiyi Jiang, Zhaoqing Yan, Matteo Di Bernardo, Samantha R Sgrizzi, Lukas Villiger, Alisan Kayabolen, Byungji Kim, Josephine K Carscadden, Masahiro Hiraizumi, Hiroshi Nishimasu, et al. Rapid protein evolution by few-shot learning with a protein language model. bioRxiv : the preprint server for biology. 2024
Toshihiro Nakane, Ryoya Nakagawa, Soh Ishiguro, Sae Okazaki, Hideto Mori, Yutaro Shuto, Keitaro Yamashita, Nozomu Yachie, Hiroshi Nishimasu, Osamu Nureki. Structure and engineering of Brevibacillus laterosporus Cas9. Communications biology. 2024. 7. 1. 803-803
Sundaram Acharya, Asgar Hussain Ansari, Prosad Kumar Das, Seiichi Hirano, Meghali Aich, Riya Rauthan, Sudipta Mahato, Savitri Maddileti, Sajal Sarkar, Manoj Kumar, et al. PAM-flexible Engineered FnCas9 variants for robust and ultra-precise genome editing and diagnostics. Nature communications. 2024. 15. 1. 5471-5471
Matthew G Durrant, Nicholas T Perry, James J Pai, Aditya R Jangid, Januka S Athukoralage, Masahiro Hiraizumi, John P McSpedon, April Pawluk, Hiroshi Nishimasu, Silvana Konermann, et al. Bridge RNAs direct programmable recombination of target and donor DNA. Nature. 2024. 630. 8018. 984-993
Masahiro Hiraizumi, Nicholas T Perry, Matthew G Durrant, Teppei Soma, Naoto Nagahata, Sae Okazaki, Januka S Athukoralage, Yukari Isayama, James J Pai, April Pawluk, et al. Structural mechanism of bridge RNA-guided recombination. Nature. 2024. 630. 8018. 994-1002

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MISC (23)：

山田崇太, 山田崇太, 加藤一希, 岡崎早恵, 平泉将浩, 平泉将浩, 西増弘志, 西増弘志, 西増弘志. CRISPR-Cas9の先祖タンパク質CRISPR-associated IscBのクライオ電子顕微鏡構造解析による進化過程の解明. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
相馬哲兵, 相馬哲兵, 平泉将浩, 諫山縁, 岡崎早恵, 加藤一希, 西増弘志, 西増弘志. 配列特異的DNA組換えタンパク質ラージセリンリコンビナーゼのクライオ電子顕微鏡構造解析. 日本蛋白質科学会年会プログラム・要旨集. 2023. 23rd (CD-ROM)
Nagano Norimichi, Honjo Megumi, Kawaguchi Mitsuyasu, Nishimasu Hiroshi, Nureki Osamu, Kano Kuniyuki, Kano Kuniyuki, Aoki Junken, Aoki Junken, Komatsu Toru, et al. Development of a Novel Intraocular-Pressure-Lowering Therapy Targeting ATX. Biological and Pharmaceutical Bulletin (Web). 2019. 42. 11
大内靖夫, Patil Ashwini, 西増弘志, 濡木理, 中井謙太, 植松智. CRISPR/Cas9ゲノム編集技術を用いたがん抗原特異的CD8+T細胞の作製. 生命科学系学会合同年次大会. 2017. 2017年度. [2P-0947]
Linyi Gao, David B. T. Cox, Winston X. Yan, John C. Manteiga, Martin W. Schneider, Takashi Yamano, Hiroshi Nishimasu, Osamu Nureki, Nicola Crosetto, Feng Zhang. Engineered Cpf variants with altered PAM specificities (vol 35, pg 789, 2017). NATURE BIOTECHNOLOGY. 2017. 35. 8

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Patents (7)：

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Professional career (1)：

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