Ichikawa Kazuhiro

Research field (1)： Biophysics

Research theme for competitive and other funds (30)：

2021 - 2024 磁場スイッチDNP-MRIによる臨床代謝計測装置の試作・実証研究
2018 - 2022 Development of multifunctional electron/nuclear magnetic resonance imaging
2018 - 2021 Development of dynamic nuclear polarization MRI for metabolic dynamics measurement
2018 - 2020 Methods of molecular electrode using magnetic resonance technique
2015 - 2018 High sensitivity spin detection

2013 - 2018 Development of a PET/OMRI combined system

2014 - 2016 In vivo imaging method for ascorbic acid

2012 - 2015 Human size OMRI scanner system

2012 - 2014 Development of highly sensitive MR molecular imaging method for early diagnosis and monitoring of Alzheimer disease

2011 - 2012 Development of molecular electrode

2011 - 2012 Development of 3D mapping technique of redox state and oxygen in vivo

2010 - 2012 Imaging study of redox status in vivo in oxidative stress-associateddisease model animals using OMRI

2009 - 2011 Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal Construction of OMRI scanner for Large Animal

2007 - 2008 OMRI resonator for imaging Systema digestorium diseases in animal

2005 - 2007 Analysis of the role of mitochondrial transcription factor in cardiovascular diseases and the development of novel therapeutic strategies

2003 - 2006 Analysis of free radical reactions in diseases model animals using in vivo ESRI

2005 - 2005 ミトコンドリア酸化ストレス制御によるインスリン抵抗性の新たな治療法の開発

2001 - 2003 Development of ESRI・MRI fused imaging device for oxidative stress-related diseases

2000 - 2001 疾患成因に関わる活性酸素・活性窒素の無侵襲画像解析手法の開発

2000 - 2001 Non-invasive evaluation of free radical reactions accompanied with induction and development of heart failure by in vivo ESR-CT

2000 - 2001 Development of specific delivery system for anti-oxidant enzymes to inflammatory lesions

1999 - 2000 Development of non-invasive system for the evaluation of free radicals in brain with encephalopathy.

1999 - 2000 in vivo ESR画像化法による炎症モデルでの酸化ストレス惹起の速度解析

1997 - 2000 Analysis of mass flow and proposal of key technologies for establishment of zero-emission processes

1998 - 1999 Analysis of toxicity by organic halogens with in vivo ESR and transgenic mice

1998 - 1998 水処理操作における有害物質の消長の検討

1997 - 1998 生体内フリーラジカル反応の速度解析を目的としたアルゴリズム開発

1997 - 1997 オゾン処理による水中有機物の反応経路の検討

1995 - 1997 Roles of in vivo REDOX systems by using in vivo ESR and transgenic mice

1996 - 1996 生体内フリーラジカル反応の数量的解析法の開発

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Papers (6)：

Imakura Y., Nonaka H., Takakusagi Y., Ichikawa K., Maptue N.R., Funk A.M., Khemtong C., Sando S. Rational Design of [13C,D14]Tert-butylbenzene as a Scaffold Structure for Designing Long-lived Hyperpolarized 13C Probes. Chemistry - An Asian J. 2018. 13. 3. 280-283
Scroggins B., Matsuo M., White A., Saito K., Munasinghe J.P., Sourbier C., Yamamoto K., Diaz V., Takakusagi Y., Ichikawa K., et al. Hyperpolarized [1-(13)C]-pyruvate magnetic resonance spectroscopic imaging of prostate cancer in vivo predicts efficacy of targeting the Warburg effect. Clin Cancer Res. 2018. 24. 13. 3137-3148
Nonaka H., Hirano M., Imakura Y., Takakusagi Y., Ichikawa K., Sando S. Design of a N-15 Molecular Unit to Achieve Long Retention of Hyperpolarized Spin State. Sci Rep. 2017. 7. 40104
Takakusagi Y., Inoue K., Naganuma T., Hyodo F., Ichikawa K. Effect of ionic interaction between a hyperpolarized magnetic resonance chemical probe and a gadolinium contrast agent for the hyperpolarized lifetime after dissolution. J Magn Reson. 2016. 270. 157-160
Hata R., Nonaka H., Takakusagi Y., Ichikawa K., Sando S. Design of a Hyperpolarized Molecular Probe for Detection of Aminopeptidase N Activity. Angew Chem Int Ed Engl. 2016. 55. 5. 1765-1768

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Patents (11)：

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