Nobuyoshi Akimitsu

アキミツノブヨシ | Nobuyoshi Akimitsu

Affiliation and department：
Job title：教授
Homepage URL (1)： https://www.ric.u-tokyo.ac.jp/akimitsu/

Research field (4)： Environmental effects of chemicals , Environmental effects of radiation , Pharmaceuticals - health and biochemistry , Molecular biology

Research keywords (4)：がん , 放射線生物学 , 生化学 , 分子生物学

Research theme for competitive and other funds (38)：

2023 - 2028 Dynamic reproductive lifespan: Life-long changes and fluctuations in germ cell function and risk for next generation
2023 - 2026 α線放出核種と抗体ドラッグデリバリーシステムによる新規放射性医薬品の開発
2021 - 2025 Study of novel stress response mechanism in human cells
2021 - 2024 Construction of Multiple Sample Analysis System Using FRET System and Search for Inhibitors of Virus Polymerization Proteins
2021 - 2023 Nuclear RNA body-mediated chromatin regulation in heat shock

2020 - 2023 眼圧と房水による眼球組織応答と緑内障ー眼圧制御機構とバイオマーカーの探索

2020 - 2022 study of post-transcriptional gene regulation in hypoxic cells from the view of metabolic adaptation

2019 - 2022 Long noncoding RNAs involved in the pathogenesis of infectious uveitis

2019 - 2022 Analysis of the treatment for gastric cancer peritoneal metastasis using hyper-selective short lived alpha-emitting radio isotope

2018 - 2022 Development of strategy to design anticancer drug based on ceRNA network

2018 - 2022 自然免疫応答を制御する長鎖非コードRNAに関する研究

2018 - 2021 RNA metabolism during cellular transition

2018 - 2021 Functional analysis of lncRNAs regulating immune response

2017 - 2021 Development of new technologies for liver surgery by using fluorescent imaging

2017 - 2020 Elucidation of functional role of long non-coding RNA in the invasion of hepatocellular carcinoma cells

2017 - 2019 Systematic discovery of short peptide coding ORFs in the human genomes

2015 - 2018 Analysis of nuclear non-coding RNA upon bacterial infection

2015 - 2018 Study of long noncoding RNAs in immune response

2015 - 2018 Mechanism of cluster DNA damage induction and its repair processes in vivo

2015 - 2017 核内長鎖ノンコーディングRNAによる転写サイクル制御

2015 - 2017 Development of cell sensor by using RNA binding protein

2014 - 2017 Search for antiviral molecules from coral reef organisms

2015 - 2016 Evaluation of radiation effect based on point mutation of BRAF gene

2011 - 2016 Establishment of new diagnostic imaging system for hepatocellular carcinoma and its application to cancer therapy

2012 - 2015 Control of Biological Effect by Altered ATP induced with Synchrotron Soft X-rays

2012 - 2014 RNA分解を介した核局在型高分子非コードRNA作用マシナリーの制御機構の解明

2012 - 2014 Study of Biological Effect induced by Radiation Damage of non-DNA Molecules

2011 - 2012 Transcriptional regulation of nuclear long noncoding RNA in mammalian cells

2011 - 2012 Body-brain holistic biology on the gravity health science platform

2010 - 2011 哺乳動物細胞の核内非コードRNA分解経路に関する研究

2010 - 2010 ノンコーディングRNAに着目した疾患マーカーの新規発見手法の開発

2008 - 2009 Analysis of translational inhibition by basic amino acid repeat

2006 - 2007 終止コドンを欠失したmRNAの特異的分解に関与するヒト遺伝子群の網羅的検索と解析

2002 - 2003 Functions of transcription elongation factor S-II for cell stress response and development

2002 - 2003 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

2002 - 2002 マウス初期胚におけるDNAトポイソメラーゼII依存チェックポイント機能低下の可能性

2001 - 2001 マウスDNAトポイソメラーゼIIαの細胞周期制御における役割に関する分子遺伝学

2000 - 2001 Functional analysis of a role of prolylendopeptidase in brain by constructing gene targeting mice

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Papers (89)：

Kenzui Taniue, Takeaki Oda, Tomoatsu Hayashi, Yuki Kamoshida, Yasuko Takeda, Anzu Sugawara, Yuki Shimoura, Lumi Negishi, Takeshi Nagashima, Mariko Okada-Hatakeyama, et al. LncRNA ZNNT1 induces p53 degradation by interfering with the interaction between p53 and the SART3-USP15 complex. PNAS Nexus. 2023
Rena Onoguchi-Mizutani, Nobuyoshi Akimitsu. Long noncoding RNA and phase separation in cellular stress response. Journal of biochemistry. 2022. 171. 3. 269-276
Kenzui Taniue, Tanzina Tanu, Yuki Shimoura, Shuhei Mitsutomi, Han Han, Rika Kakisaka, Yusuke Ono, Nobue Tamamura, Kenji Takahashi, Youichiro Wada, et al. RNA Exosome Component EXOSC4 Amplified in Multiple Cancer Types Is Required for the Cancer Cell Survival. International Journal of Molecular Sciences. 2022. 23. 1. 496-496
Tanzina Tanu, Kenzui Taniue, Katsutoshi Imamura, Rena Onoguchi-Mizutani, Han Han, Torben Heick Jensen, Nobuyoshi Akimitsu. hnRNPH1-MTR4 complex-mediated regulation of NEAT1v2 stability is critical for IL8 expression. RNA Biology. 2021. 18. sup1. 537-547
Yui Obata, Hiroki Nakaue, Keishiro Hirasaki, Nobuyoshi Akimitsu, Akinari Yokoya. Expression of an X-Ray Irradiated EGFP-Expressing Plasmid Transfected into Nonirradiated Human Cells. Radiation research. 2021. 196. 3. 261-271

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MISC (85)：

秋光信佳, 小野口玲菜, 川村猛, Diederichs Sven, 鈴木穣. ノンコーティングRNAによるエピジェネティクスの制御ストレス応答における核内長鎖ノンコーディングRNAの働き(Epigenetic regulation by non-coding RNAs Functions of nuclear long noncoding RNAs in stress responses). 日本癌学会総会記事. 2019. 78回. IS12-4
秋光信佳. 中分子創薬への放射線活用. 日本薬学会年会要旨集. 2019. 139年会. 1. 343-343
川田健太郎, 脇田寛泰, 関真秀, 鈴木穣, 秋光信佳. 修飾核酸を用いた転写およびRNA分解の同時測定手法の開発. 日本RNA学会年会要旨集. 2019. 21st
秋光信佳. 【ncRNAの医科学と医療I】がん研究におけるncRNAの重要性長鎖ncRNAのMALAT1の例. 医学のあゆみ. 2018. 267. 8. 583-586
山田俊理, 今町直登, 仲木竜, 川村猛, 長浜正巳, 秋光信佳. PUM1タンパク質によるmRNA分解制御が、DNA障害後の細胞生存を促進する. 日本放射線影響学会大会講演要旨集. 2018. 61回. 50-50

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Patents (6)：

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Books (3)：

遺伝子発現制御機構 : クロマチン, 転写制御, エピジェネティクス
東京化学同人 2017 ISBN:9784807909179
細胞の酸化ストレス応答並びに個体発生における転写伸長因子S-IIの機能
関水和久 2004
遺伝子ノックアウトマウス作製によるプロリルエンドぺプチターゼの脳における機能解析
秋光信佳 2002

Professional career (1)：

博士(薬学) (九州大学)

Association Membership(s) (6)：

THE JAPANESE RADIATION RESEARCH SOCIETY , THE RNA SOCIETY OF JAPAN , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE PHARMACEUTICAL SOCIETY OF JAPAN , RNA society , 日本癌学会

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