2022 - 2025 Development of nucleic acid-loaded ultrasound-responsive nanobubbles for the treatment of lung diseases
2021 - 2024 Development of ultrasound-responsive nanobubbles specialized on heart failure and construction of a disease treatment system
2019 - 2022 Development of novel theranostics system using photoacoustic and ultrasound-responsive nanobubbles
2019 - 2022 Development of nucleic acid-loaded nanobubbles for the neurovascular unit protection from cerebral ischemia
2018 - 2021 Development of ultrasound-responsive nanobubbles containing genome editing tools and establishment of disease treatment system
2016 - 2019 Development of antibody delivery system by ultrasound responsive nano bubble and breast cancer treatment strategy
2017 - 2019 Development of brain-targeting nucleic acids-loaded nanobubbles for the therapy of cerebrovascular accident in combination with ultrasound
2015 - 2018 Development of ultrasound-responsive nanobubbles containing physiologically active gas and construction of disease treatment system
2013 - 2016 Ultrasound-mediated gene delivery system into brain tissue by blood brain barrier targeting Bubble liposomes
2012 - 2016 Combination of nucleic acid-loaded Bubble liposomes and high-intensity focused ultrasound for therapy of cerebrovascular accident
2011 - 2014 Therapeutic systems of muscular dystrophy by morpholino oligonucleotide-loaded nanobubble and ultrasound
2010 - 2012 Gene transfer system into mesenchymal stem cell by peptide-modified liposomes and ultrasound technology
2009 - 2012 Novel angiogenic therapy using siRNA-loaded Bubble liposomes with ultrasound exposure
2008 - 2010 Low invasive therapeutic system for vascular diseases by neovascular specific liposomes containing US-contrast gas
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Papers (60)：
Yusuke Yano, Rui Tada, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Motoyoshi Nomizu, Yoichi Negishi. Development of a concise and reliable method for quantifying the antibody loaded onto lipid nanoparticles modified with Herceptin. Journal of Immunological Methods. 2023. 521. 113554-113554
Shohko Sekine, Sayaka Mayama, Nobuaki Nishijima, Takuo Kojima, Yoko Endo-Takahashi, Yuko Ishii, Hitomi Shiono, Saki Akiyama, Akane Sakurai, Sanae Sashida, et al. Development of a Gene and Nucleic Acid Delivery System for Skeletal Muscle Administration via Limb Perfusion Using Nanobubbles and Ultrasound. Pharmaceutics. 2023. 15. 6. 1665
Yusuke Yano, Nobuhito Hamano, Kenshin Haruta, Tomomi Kobayashi, Masahiro Sato, Yamato Kikkawa, Yoko Endo-Takahashi, Rui Tada, Ryo Suzuki, Kazuo Maruyama, et al. Development of an Antibody Delivery Method for Cancer Treatment by Combining Ultrasound with Therapeutic Antibody-Modified Nanobubbles Using Fc-Binding Polypeptide. Pharmaceutics. 2022. 15. 1. 130-130
Yoko Endo-Takahashi, Yoichi Negishi. Gene and oligonucleotide delivery via micro- and nanobubbles by ultrasound exposure. Drug metabolism and pharmacokinetics. 2022. 44. 100445-100445
2012/05 - The 4th Asian Conference on Ultrasound Contrast Imaging Travel Grant Award
2009/11 - 第8回日本超音波治療研究会 若手研究者最優秀賞
2008/07 - 11th Liposome Research Days Conference The Young Inestigator Award
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Association Membership(s) (4)：
遺伝子・デリバリー研究会
, THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM
, THE ACADEMY OF PHARMACEUTICAL SCIENCE AND TECHNOLOGY, JAPAN
, THE PHARMACEUTICAL SOCIETY OF JAPAN
