Hosoi Shinzo

Research field (1)： Pharmaceuticals - chemistry and drug development

Research theme for competitive and other funds (8)：

2014 - 2017 Establishment of practical determination method of absolute configuration based on induced circular dichroism and quantum chemical approach to elucidation of its origin
2011 - 2013 Development of determination method of absolute configuration using binaphthyl CD probe and its application to natural products
2010 - 2012 Development of the construction of multi contiguous chiral carbons by using recyclable chiral amine.
2009 - 2012 Strategic Study on Environmentally and/or Biologically ExpressingToxicity of Polycyclic Aromatic Hydrocarbons
2008 - 2010 Development of determination method of absolute configuration of natural products based on induced exciton coupling, computed by quantum chemical calculation

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Papers (42)：

Aya Niki, Minoru Ozeki, Akiko Kuse, Shiho Nakagawa, Shui Aoki, Takashi Shigeta, Tetsuya Kajimoto, Hiroki Iwasaki, Naoto Kojima, Kenji Arimitsu, et al. Construction of Acyclic All-Carbon Quaternary Stereocenter Based on Asymmetric Michael Addition of Chiral Amine. Chemical and Pharmaceutical Bulletin. 2021. 69. 9. 926-930
Toshio Fujiwara, Yuka Taniguchi, Yuri Kokuryu, Yuumi Baba, Daiki Kawano, Yuuki Kawakami, Shouta Suzuki, Yukiteru Katsumoto, Minoru Ozeki, Hiroki Iwasaki, et al. Application of a novel chromophoric reagent, 2,2′-binaphthyl-3,3′-dicarbonyl cyanide, to the absolute configuration determination of chiral secondary alcohols. Tetrahedron Letters. 2020. 61. 24. 151984-151984
Minoru Ozeki, Ayumi Hachino, Takashi Shigeta, Aya Niki, Natsuko Kobayashi, Hideki Mizutani, Akihiro Nakamura, Ayano Horie, Kenji Arimitsu, Tetsuya Kajimoto, et al. A facile and convenient synthesis of trisubstituted (E)-α,β-unsaturated esters by tandem acetylation-E1CB reaction. Chemical and Pharmaceutical Bulletin. 2019. 67. 1. 71-74
Misuzu Ishikawa, Shota Hirai, Tatsusada Yoshida, Natsumi Shibuya, Susumu Hama, Yu Takahashi, Tatsuya Fukuta, Tamotsu Tanaka, Shinzo Hosoi, Kentaro Kogure. Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol. Chemical & Pharmaceutical Bulletin. 2018. Vol.66. No.7. 714-720
Ishikawa M, Hirai S, Yoshida T, Shibuya N, Hama S, Takahashi Y, Fukuta T, Tanaka T, Hosoi S, Kogure K. Carotenoid Stereochemistry Affects Antioxidative Activity of Liposomes Co-encapsulating Astaxanthin and Tocotrienol. Chemical & pharmaceutical bulletin. 2018. 66. 7. 714-720

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MISC (141)：

The importance of early establishment of basic subjects (physics, chemistry, biology) and pharmacology in passing the the National Examination for Pharmacists: Based on the analysis of the results of the trial tests and recent the National Examination for Pharmacists. 2021. 2. 2. 170-178
Relationship between results of the National Examination for Pharmacists and trial test scores: towards effective educational support for candidates of the six-year system. 2021. 2. 1. 44-51
小暮健太朗, 石川みすず, 平井将太, 浜進, 吉田達貞, 高橋侑, 細井信造, 福田達也, 田中保. α-トコトリエノールとアスタキサンチンの相乗的抗酸化効果. ビタミン. 2018. 92. 5/6. 284-285
石川みすず, 平井将太, 浜進, 細井信造, 吉田達貞, 高橋侑, 福田達也, 田中保, 小暮健太朗. アスタキサンチンとα-トコトリエノールの相乗的抗酸化効果における立体構造の影響. 日本薬学会年会要旨集(CD-ROM). 2018. 138th. ROMBUNNO.28U-am03
小暮健太朗, 石川みすず, 平井将太, 浜進, 細井信造, 吉田達貞, 山下栄次, 高橋侑. ビタミンEとの相乗的抗酸化効果におけるアスタキサンチン立体構造の影響. 日本酸化ストレス学会学術集会プログラム・抄録集. 2017. 70th. 113

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Patents (3)：

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