Atsuhiko Naito

ナイトウアツヒコ | Atsuhiko Naito

Affiliation and department：
Homepage URL (1)： https://www.toho-u.ac.jp/med/lab/lab_cytophysiology.html

Research field (4)： Cell biology , Cardiology , Physiology , Pharmacology

Research keywords (9)：心筋細胞 , 心不全 , 発生・分化 , 老化 , DNA損傷 , iPS細胞 , 安全性薬理 , 創薬 , 心臓発生

Research theme for competitive and other funds (6)：

2019 - 2023 心筋細胞特有のゲノムDNA損傷応答機構の解明
2014 - 2017 Epigenome analysis in cardiomyocyte differentiation and failure
2014 - 2016 Development of a System to Obtain Mature Ventricular Cardiomyocytes from Human induced Pluripotent Stem cells
2011 - 2014 The role of C1q and Wnt signaling in aging and diabetes
2011 - 2013 What is the physiological role of cardiac stem cells ?

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Papers (34)：

沼田玄理, 瀧本英樹, 大津裕, 豊田真之, 内藤篤彦, 小室一成. Role of Beta 1 Adrenergic Receptor in Acute Heart Failure: Analysis of Cardiomyocyte-Specific Knockout of Beta 1 Adrenergic Receptor(タイトル和訳中). 日本循環器学会学術集会抄録集. 2023. 87回. OJ61-3
Shigeyuki Magi, Sewon Ki, Masao Ukai, Elisa Domínguez-Hüttinger, Atsuhiko T Naito, Yutaka Suzuki, Mariko Okada. A combination approach of pseudotime analysis and mathematical modeling for understanding drug-resistant mechanisms. Scientific reports. 2021. 11. 1. 18511-18511
Hideki Yasutake, Jong-Kook Lee, Akihito Hashimoto, Kiyoshi Masuyama, Jun Li, Yuki Kuramoto, Shuichiro Higo, Shungo Hikoso, Kyoko Hidaka, Atsuhiko T Naito, et al. Decreased YAP activity reduces proliferative ability in human induced pluripotent stem cell of duchenne muscular dystrophy derived cardiomyocytes. Scientific reports. 2021. 11. 1. 10351-10351
Shigeyuki Magi, Sewon Ki, Masao Ukai, Atsuhiko Naito, Yutaka Suzuki, Mariko Okada. Mathematical Modeling and Transcriptome Profiling of Breast Cancer Cells During Tamoxifen Treatment Reveal Multiple Trajectories for Resistant Subtypes. 2021
Toshihiro Yamaguchi, Tomokazu S Sumida, Seitaro Nomura, Masahiro Satoh, Tomoaki Higo, Masamichi Ito, Toshiyuki Ko, Kanna Fujita, Mary E Sweet, Atsushi Sanbe, et al. Cardiac dopamine D1 receptor triggers ventricular arrhythmia in chronic heart failure. Nature communications. 2020. 11. 1. 4364-4364

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MISC (118)：

Masato Shibamoto, Tomoaki Higo, Atsuhiko T. Naito, Akito Nakagawa, Tomokazu Sumida, Katsuki Okada, Taku Sakai, Yuki Kuramoto, Toshihiro Yamaguchi, Masamichi Ito, et al. Activation of DNA Damage Response and Cellular Senescence in Cardiac Fibroblasts Limit Cardiac Fibrosis After Myocardial Infarction (vol 60, pg 944, 2019). INTERNATIONAL HEART JOURNAL. 2021. 62. 1. 220-220
杉山篤, 長澤(萩原, 美帆子, 神林隆一, 後藤愛, 千葉浩輝, 安東賢太郎, 内藤篤彦, 中瀬古(泉)寛子. 拡張不全型心不全(HFpEF)に対する新しい薬物治療法の開発. 冲中記念成人病研究所年報. 2019. 45. 98-101
谷川洋一, 長澤美帆子, 原, 後藤愛, 千葉浩輝, 神林隆一, 近藤嘉紀, 篠崎誠, 中瀬古寛子, 内藤篤彦, et al. 安全性薬理評価モデルとしてのmicrominipigの特徴づけ:fluvoxamineにより誘発される有害作用の分析. 東邦医学会雑誌. 2019. 66. 1. 69-69
神林隆一, 長澤美帆子, 原, 後藤愛, 千葉浩輝, 近藤嘉紀, 谷川洋一, 篠崎誠, 中瀬古寛子, 内藤篤彦, et al. Perospironeおよびblonanserin投与後にTdPを発症したLQT3型症例における不整脈発生機序の実験的検討. 東邦医学会雑誌. 2019. 66. 1. 77-77
神林隆一, 長澤美帆子, 原, 後藤愛, 千葉浩輝, 近藤嘉紀, 谷川洋一, 篠崎誠, 中瀬古寛子, 内藤篤彦, et al. セロトニン・ドパミン遮断薬perospironeおよびblonanserin投与後にTdPを発症したLQT3症例における不整脈発生機序の実験的検討. 血管. 2019. 42. 1. 41-41

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Patents (2)：

Lectures and oral presentations (18)：

Pathogenic role of DNA single-strand break accumulation and DNA damage response in pressure overload-induced heart failure.
(WCP2018 2018)
Assessment of the drug-induced cardiac functional toxicity by pattern-cultured hiPSC-CMs.
(WCP2018 2018)
TRPC3 Inhibitor Pyr3 Corrects the Disease-specific Phenotype of the Induced Pluripotent Stem Cell-derived Cardiomyocytes from the Patients with Infantile Hypertrophic Cardiomyopathy.
(WCP2018 2018)
Assessment of the drug-induced toxicity against left ventricular function by pattern-cultured hiPSC-CMs.
(Safety Pharmacology Science Annual Meeting 2018)
ヒトiPS細胞由来心筋細胞を利用した医薬品の安全性評価
(第22回日本心血管内分泌代謝学会 2018)

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Professional career (1)：

博士(医学) (千葉大学)

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