Rchr

J-GLOBAL ID：201801010271218021 Update date: Nov. 21, 2024

Kobayashi Hirokazu

Affiliation and department：
Job title： CEO
Other affiliations (1)：

University of Shizuoka Visiting Professor, School of Pharmaceutical Sciences

Homepage URL (2)： https://www.ginsight-jpn.biz/ceo-profile , https://en.ginsight-jpn.biz/ceo-profile

Research field (1)： Molecular biology

Research keywords (8)： salt tolerance , Camellia sinensis , tea , Arabidopsis , antibody drug , biologics , photosynthesis , chloroplast

Research theme for competitive and other funds (32)：

2024 - 2025 Cultivation of genome-edited tea plants as raw materials for aroma-enhanced tea for the global market
2023 - 2024 Improvement of tea plants by knockout-type genome editing for a decaf beverage
2023 - 2024 Utilization of ambient solution during plant culture
2020 - 2022 Commercialization of vegetables enriched with sugar, nutraceuticals, and pharmaceuticals based on the enhanced photosynthetic activity
2015 - 2018 Studies on the efficacy of toxin neutralization and safety of Shiga toxin-specific secretory IgA type plantibody produced by practical plants

2013 - 2015 Mucosal surface defense by edible IgA produced by plants

2013 - 2015 "Light-switch" for higher production of foreign proteins in plant chloroplasts

2012 - 2015 Elucidation of inhibitory mechanisms of transcriptional light switch for development of plants specialized for growth in artificial light.

2011 - 2014 Elucidation of mechanisms governing selectable expression of chloroplast genes and its application to plant improvement

2011 - 2012 Expression of secretory immunoglobulin A in lettuce suitable for the production of therapeutic antibodies in plantfactory.

2010 - 2012 New mutagenesis approaches to study gene function in crop

2010 - 2012 Reverse genetics and recombination

2007 - 2008 花粉を介して飛散しない可食を目的とした植物形質転換マーカーの開発

2002 - 2003 外来選択マーカーを用いない葉緑体遺伝子導入系の樹立

2000 - 2002 Mechanisms of response to environmental stresses with active oxygen species-detoxification in higer plants

2000 - 2000 葉緑体機能発現のシグマ因子を介する核支配調節機構

1999 - 1999 シグマ因子を介する葉緑体光合成遺伝子発現の核支配調節機構

1998 - 1998 葉緑体光合成遺伝子発現制御シグマ因子をコードする核遺伝子の発現調節機構

1996 - 1998 Molecular Genetics of Host-Specific Toxins in Plant Disease

1993 - 1995 MOLECULAR BASIS FOR SPECIALIZATION AND EVOLUTION OF PATHOGENICITY IN ALTERNARIA PATHOGENS THAT HOST-SPECIFIC TOXINS INVOLVE IN

1993 - 1994 Molecular Organization of Photsystem II

1993 - 1994 U.S.-Japan Joint Research on Molecular Biology of Host-specific Toxins as Pathogenicity

1993 - 1993 シロイヌナズナ突然変異体を用いた光合成環境応答機構の解析

1992 - 1992 光合成環境応答遺伝子解析のためのシロイヌナズナ分子遺伝学実験系の樹立

1990 - 1992 MOLECULAR PATHOLOGY OF PLANT INFECTION MEDIATED BY HOST-SPECIFIC TOXINS

1991 - 1991 シロイヌナズナを用いた光合成遺伝子発現に介在するシグナル伝達機構の解析

1990 - 1991 Approaches with Arabidopsis thaliana Mutants to the Regulatory Genes for Photosynthesis

1990 - 1991 U. S. -Japan joint research on the molecular pathology of host-specific-toxin-depending fungal infection to plants

1988 - 1988 植物病原菌の宿主特異的毒素:その宿主識別における役割

1987 - 1988 Studies for biosynthesis, transport, secreation of glycoprotein in higher plant.

1986 - 1988 Photosynthetic Genes and Their Expression

1985 - 1987 Biochemical and molecular biological study on Subunit interaction of RuBisCO

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Papers (102)：

Katsuhiro Nakanishi, Taichi Takase, Yuya Ohira, Ryota Ida, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Kohta Kurohane, Yoshihiro Akimoto, Junri Hayakawa, et al. Prevention of Shiga toxin 1-caused colon injury by plant-derived recombinant IgA. Scientific Reports. 2022. 12. 1
Katsuhiro Nakanishi, Noriko Mogi, Yuki Kikuchi, Minami Matsuda, Takeshi Matsuoka, Kotome Shiina, Shota Morikane, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, et al. Plant-derived secretory component gives protease-resistance to Shiga toxin 1-specific dimeric IgA. Plant Molecular Biology. 2021. 106. 3. 297-308
Katsuhiro Nakanishi, Minami Matsuda, Ryota Ida, Nao Hosokawa, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai. Lettuce-derived secretory IgA specifically neutralizes the Shiga toxin 1 activity. Planta. 2019. 250. 4. 1255-1264
Katsuhiro Nakanishi, Shota Morikane, Nao Hosokawa, Yuka Kajihara, Kohta Kurohane, Yasuo Niwa, Hirokazu Kobayashi, Yasuyuki Imai. Plant-derived secretory component forms secretory IgA with shiga toxin 1-specific dimeric IgA produced by mouse cells and whole plants. Plant cell reports. 2019. 38. 2. 161-172
清水正則, 小林裕和, 小林裕和. 付加価値農作物生産のためのデータベースの活用. 明日の食品産業. 2017. 2017. 9. 26-32-32

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MISC (14)：

編纂: 小林裕和, 中村順行, 細川光洋. 静岡県立大発まんがしずおかのDNA. 静岡新聞, 朝刊, 月曜日, 科学面, 30回連載 (https://www.at-s.com/news/featured/culture_life/kenritsudai_column/index.html). 2020
小林裕和. バイオで戦え --- 地域資源を生かし発展. 静岡県立大発まんがしずおかのDNA 9, 静岡新聞. 2020
Hirokazu Kobayashi. Engineering of plants for production of provisions and nutraceuticals. The Final Reports: Global COE Program of University of Shizuoka "Global Center of Excellence for Innovation in Human Health Sciences". 2012. 20-21
Tomomi Fujino, Yoshihiko Ito, Yuko Taki, Nozomi Kakizawa, Satomi Onoue, Yasuyuki Imai, Naoto Oku, Hiroshi Noguchi, Kunihiko Itoh, Hirokazu Kobayashi, et al. Literature search on the interaction between warfarin and vitamin K. Japanese Journal of Clinical Pharmacology and Therapeutics. 2010. 41. 1. 43-52
Ogawa Takeshi, Kobayashi Hirokazu, Funato Nana, Murakami Yukiko, Niwa Yasuo, Shimizu Masanori, Sakakibara Hiroyuki, Min Junzhe, Toyooka Toshimasa, Nakanishi Motoyasu. Application of irradiant LED and genetic modification to polyphenol enrichment of plants. Plant and Cell Physiology Supplement. 2009. 2009. 0. 71-71

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Patents (12)：

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Books (1)：

10年後の静岡を創るスーパーセミナー --- 知の丘を往く (デジタル版)
静岡県立大学 (https://www.u-shizuoka-ken.ac.jp/guide/30th-anniversary/superseminar/) 2018 ISBN:9784991027802

Lectures and oral presentations (86)：

Can We Recover Our Reputation for Japanese Research? Expectations for Universities
(2023)
植物工場における高付加価値化・亜臨界水抽出
(静岡商工会議所新産業開発振興機構創立20周年記念式典 2023)
奈良先端大におけるURAの活動と成果
(文部科学省研究大学強化促進事業シンポジウム「URAが活躍するための原動力と機能 --- URAの定着に向けて改めて問う」 2022)
(株)グリーン・インサイト --- バイオの力で未来を拓く
(静岡県大学発ベンチャー事業化加速支援 meetup静岡 2022)
参加と創業のススメ
((株)リバネス主催「テックプランター」 2021)

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Education (2)：

1977 - 1982 Nagoya University Graduate School of Agriculture Department of Agricultural Chemistry
1973 - 1977 Tottori University Faculty of Agriculture Department of Agranomy

Professional career (3)：

Ph.D. (Nagoya University)
M.S. (Nagoya University)
B.S. (Tottori University)

Work history (19)：

2020/08 - 現在 Green Insight Japan, Inc. CEO
2020/04 - 現在 University of Shizuoka Visiting Professor
2020/04 - 現在 University of Shizuoka Professor Emeritus
2021/10 - 2023/03 Nara Institute of Science and Technology Division of Research Strategy Division Director
2003/04 - 2020/03 University of Shizuoka Laboratory of Plant Molecular Improvement Professor

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Committee career (16)：

2016/04 - 2018/03 Marine Industry Cluster Council of Shizuoka City Committee Member
2015/04 - 2017/03 Shizuoka Technology Transfer Organization L.L.C. Managing Partner
2015/04 - 2017/03 Shizuoka Prefectural Community Chest Trustee/Councilor
2015/04 - 2017/03 World O-CHA(Tea) Festival Steering Committee Member
2011 - 2013 Japan Society for the Promotion of Science (JSPS) Specialist Committee Member

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Awards (3)：

2018 - Leave a Nest Co., Ltd. Finalist, Agri-tech Grand Prix Biologics production by the savior "light-switch" in plants
2018 - Leave a Nest Co., Ltd. Yamaha Motor Award, Shizuoka Tech Grand Prix Low-cost production of biologics by chloroplast engineering with "light-switch" for expressing exogenous genes in plants
1992 - Toray Science Foundation Toray Science Technology Research Award Molecular genetical analysis of mechanisms of responses to environmental stresses in plants

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