Research theme for competitive and other funds (27)：
2023 - 2026 Development of a novel therapeutic approach for diabetic nephropathy by nucleic acid medicine (DNA aptamer).
2022 - 2025 Functional optimization and establishment of comprehensive evaluation of membrane-permeable aptamers for drug development using AI technology
2015 - 2018 Development of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples
2015 - 2018 Substrate identification method for protein phosphatases through the induction of enzyme-substrate intermediate
2015 - 2018 Investigation of biosynthetic mechanism of cyclic tetrapyrrole: Construction and cyclization of hydroxymethylbilane
2014 - 2017 Studies on structural biology of the enzymes involved in porphyria
2013 - 2016 Research of scientific cognition and social cognition for radiation and nuclear and construction of their education system
2013 - 2016 ヘムオキシゲナーゼの翻訳後修飾による量的・質的制御と細胞保護との関係
2012 - 2015 Electron transfer sytem to heme oxygenase from cytochrome P450
2012 - 2015 The mechanism of construction and cyclization of tetrapyrrole in the heme biosynthetic pathway
2009 - 2012 The role of the ubiquitin-proteasome pathway in heme oxygenase system
2009 - 2011 Investigation of the intermediary steps and electron transfer mechanism of heme degradation by heme oxygenase
2006 - 2009 Regulation of heme oxygenase activity by caveolin
2006 - 2008 Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism
2006 - 2008 PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATURE
2006 - 2008 The intermediate steps of heme oxygenase reaction and the physiological significance of carbon monoxide as a gaseous transmitter
2003 - 2006 リン酸化によるヘムオキシゲナーゼの機能調節機構の検討
2004 - 2005 Functional Structure Analysis of Ion-channel Oligomer and Production of regulating Peptides.
2003 - 2005 Studies of heme degradation mechanism by heme oxygenase based on the crystal structures.
2003 - 2005 How does heme degrade ? -Studies of the catalytic mechanism of heme oxygenase based on its crystal structures-
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Papers (109)：
Yusaku Mori, Makoto Ohara, Michishige Terasaki, Naoya Osaka, Hironori Yashima, Tomomi Saito, Yurie Otoyama-Kataoka, Takemasa Omachi, Yuichiro Higashimoto, Takanori Matsui, et al. Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice. Biomedicines. 2023. 11. 12. 3112-3112
Tanaka Kenji, Higashimoto Yuichiro, Tomizawa Mituru, Motomiy Yasuki, Kaneko Yoshiteru. Circulating Levels of Fibroblast Growth Factor 23 Selective for C-Terminal (FGF23-CT) in Hemodialysis Patients. Journal of Clinical Nephrology. 2023. 7. 3. 085-091
Michishige Terasaki, Keita Shibata, Yusaku Mori, Tomomi Saito, Takanori Matsui, Makoto Ohara, Tomoyasu Fukui, Keiji Hasumi, Yuichiro Higashimoto, Koji Nobe, et al. SMTP-44D Inhibits Atherosclerotic Plaque Formation in Apolipoprotein-E Null Mice Partly by Suppressing the AGEs-RAGE Axis. International Journal of Molecular Sciences. 2023. 24. 7. 6505-6505
Yuichiro Higashimoto, Yoshihiro Motomiya. Heparin and β2-microglobulin amyloidogenesis. GSC Biological and Pharmaceutical Sciences. 2023. 22. 2. 070-078
Kenji Tanaka, Yasuki Motomiya, Yoshiteru Kaneko, Yuichiro Higashimoto, Tatsuo Yoneda. Serum Intact and Total Fibroblast Growth Factor 23 Levels and Iron-related Parameters in Hemodialysis Patients. Journal of Clinical and Medical Research. 2022. 4. 5. 1-18
THE JAPANESE PHARMACOLOGICAL SOCIETY
, 日本核酸医薬学会
, THE MOLECULAR BIOLOGY SOCIETY OF JAPAN
, THE JAPANESE SOCIETY FOR DIALYSIS THERAPY
, THE CHEMICAL SOCIETY OF JAPAN
, THE JAPANESE BIOCHEMICAL SOCIETY
