Higashimoto Yuichiro

ヒガシモトユウイチロウ | Higashimoto Yuichiro

Affiliation and department：
Job title：教授
Homepage URL (1)： http://research.kurume-u.ac.jp/data.php?scode=38305632881848

Research field (1)： Functional biochemistry

Research keywords (5)： Aptamer , Post-translational modification , Chemical biology , protein-protein interaction , iron metabolism

Research theme for competitive and other funds (27)：

2023 - 2026 Development of a novel therapeutic approach for diabetic nephropathy by nucleic acid medicine (DNA aptamer).
2022 - 2025 Functional optimization and establishment of comprehensive evaluation of membrane-permeable aptamers for drug development using AI technology
2022 - 2025 内因性一酸化炭素COの産生調節機構の解明と新規メディカルガスによる治療基盤の構築
2020 - 2023 Development of Next-Generation Platform for Light-induced Drugs
2019 - 2022 Elucidation of the mechanism for auto-penetrating DNA aptamers and their application as post-antibody drugs

2019 - 2022 Identification of structures of advanced glycation end-products responsible for proatherosclerotic effects - analysis using aptamers.

2019 - 2022 Post-translational modifications regulating the activity and function of carbon monoxide synthase

2016 - 2019 Development of novel treatment for diabetic nephropathy originate from functional modified peptides of pigment epitherium-derived factor.

2016 - 2019 翻訳後修飾によるヘムオキシゲナーゼの機能調節とその破綻による疾患発症との関係

2015 - 2018 Development of heme oxygenase-1-based heme sensor for quantifying free heme in biological samples

2015 - 2018 Substrate identification method for protein phosphatases through the induction of enzyme-substrate intermediate

2015 - 2018 Investigation of biosynthetic mechanism of cyclic tetrapyrrole: Construction and cyclization of hydroxymethylbilane

2014 - 2017 Studies on structural biology of the enzymes involved in porphyria

2013 - 2016 Research of scientific cognition and social cognition for radiation and nuclear and construction of their education system

2013 - 2016 ヘムオキシゲナーゼの翻訳後修飾による量的・質的制御と細胞保護との関係

2012 - 2015 Electron transfer sytem to heme oxygenase from cytochrome P450

2012 - 2015 The mechanism of construction and cyclization of tetrapyrrole in the heme biosynthetic pathway

2009 - 2012 The role of the ubiquitin-proteasome pathway in heme oxygenase system

2009 - 2011 Investigation of the intermediary steps and electron transfer mechanism of heme degradation by heme oxygenase

2006 - 2009 Regulation of heme oxygenase activity by caveolin

2006 - 2008 Enzyme chemical study of heme oxygenase and development for machinery of heme catabolism

2006 - 2008 PHYSIOLOGICAL ROLE OF THE SIDE-CHAIN ASYMMETRY OF PORPHYRINES THAT ARE UTILIZED IN NATURE

2006 - 2008 The intermediate steps of heme oxygenase reaction and the physiological significance of carbon monoxide as a gaseous transmitter

2003 - 2006 リン酸化によるヘムオキシゲナーゼの機能調節機構の検討

2004 - 2005 Functional Structure Analysis of Ion-channel Oligomer and Production of regulating Peptides.

2003 - 2005 Studies of heme degradation mechanism by heme oxygenase based on the crystal structures.

2003 - 2005 How does heme degrade ? -Studies of the catalytic mechanism of heme oxygenase based on its crystal structures-

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Papers (111)：

Yoshihiro Motomiya, Yoshiteru Kaneko, Yasuki Motomiya, Yuichiro Higashimoto. Serum Levels of the C-terminal Fragment of Fibroblast Growth Factor 23 (C-FGF23) and Hepcidin in Patients with Hemodialysis Undergoing Treatment with a Proline Hydroxylase Domain (PHD) Inhibitor. Journal of Clinical Nephrology. 2024. 8. 3. 132-137
Yusaku Mori, Michishige Terasaki, Naoya Osaka, Tomoki Fujikawa, Hironori Yashima, Tomomi Saito, Yurie Kataoka, Makoto Ohara, Yuichiro Higashimoto, Takanori Matsui, et al. DNA Aptamer Raised against Advanced Glycation End Products Improves Sperm Concentration, Motility, and Viability by Suppressing Receptors for Advanced Glycation End Product-Induced Oxidative Stress and Inflammation in the Testes of Diabetic Mice. International Journal of Molecular Sciences. 2024. 25. 11. 5947-5947
Yoshihiro Motomiya, Yoshiteru Kaneko, Yuichiro Higashimoto. Clinical Usefulness of the serum-Soluble Transferrin Receptor in Iron Dysregulation Associated with long-Term Hemodialysis. International Journal of Clinical Case Reports and Reviews. 2024. 17. 02. 01-07
Yusaku Mori, Makoto Ohara, Michishige Terasaki, Naoya Osaka, Hironori Yashima, Tomomi Saito, Yurie Otoyama-Kataoka, Takemasa Omachi, Yuichiro Higashimoto, Takanori Matsui, et al. Subcutaneous Infusion of DNA-Aptamer Raised against Advanced Glycation End Products Prevents Loss of Skeletal Muscle Mass and Strength in Accelerated-Aging Mice. Biomedicines. 2023. 11. 12. 3112-3112
Tanaka Kenji, Higashimoto Yuichiro, Tomizawa Mituru, Motomiy Yasuki, Kaneko Yoshiteru. Circulating Levels of Fibroblast Growth Factor 23 Selective for C-Terminal (FGF23-CT) in Hemodialysis Patients. Journal of Clinical Nephrology. 2023. 7. 3. 085-091

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MISC (123)：

外川内亜美, 古賀義法, 東元祐一郎, 西野友梨, 松井孝憲, 山岸昌一. 終末糖化産物受容体を阻害するDNAアプタマーはLPS誘導性敗血症マウスの生存率を改善する. 糖尿病. 2023. 66. Suppl.1. S-219
HIGASHIMOTO Yuichiro, MATSUI Takanori, SAKAGUCHI Tatsuya, TANAKA Yu, MOTOMIYA Yoshihiro. Fibroblast growth factor 23 contributes to regulation of hepcidin/ferroportin axis. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th
古賀義法, 外川内亜美, 東元祐一郎, 西野友梨, 松井孝憲, 角間辰之, 秋葉純, 田中芳明, 八木実, 加治建, et al. 終末糖化産物受容体を阻害するRAGEアプタマーはヒト単球細胞の細胞死を改善する. 外科と代謝・栄養. 2023. 57. 3. 159-159
松井孝憲, 坂口達也, 東元祐一郎, 山岸昌一. スルフォラファンの抗AGEs-RAGE作用. 日本食品化学学会総会・学術大会講演要旨集. 2023. 29th
松井孝憲, 東元祐一郎, 外川内亜美, 山岸昌一. DNA aptamers against AGE-RAGE axis inhibit growth and metastasis of malignant melanoma in mice. 日本分子生物学会年会プログラム・要旨集(Web). 2023. 46th

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Patents (10)：

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Association Membership(s) (6)：

THE JAPANESE PHARMACOLOGICAL SOCIETY , 日本核酸医薬学会 , THE MOLECULAR BIOLOGY SOCIETY OF JAPAN , THE JAPANESE SOCIETY FOR DIALYSIS THERAPY , THE CHEMICAL SOCIETY OF JAPAN , THE JAPANESE BIOCHEMICAL SOCIETY

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